Immunohistochemistry News and Research

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Immunohistochemistry (IHC) is an imaging technique to visualize antigens in cells. Labeled antibodies bind to target antigens in the cell to image the distribution and localization of specific proteins of interest

Mice study unravels the role of T. denticola in Alzheimer's disease pathogenesis

Tau hyperphosphorylation is the key characteristic pathological hallmarks of Alzheimer's disease (AD). Recently studies showed periodontitis and periodontal pathogen are significant risk factors for AD.

26 Jun 2022

The presence of residual SARS-CoV-2 antigens in post-convalescent tissues

Researchers investigated the residual SARS-CoV-2 antigen found in long COVID-19 patients.

9 Jun 2022

Exploring virological profiles of recently emerged SARS-CoV-2 Omicron variants

Researchers explored the virological profiles of novel SARS-CoV-2 Omicron variants.

30 May 2022

Using diffusion-weighted MRI to visualize brain inflammation in vivo for the first time

Research of the laboratories led by Dr. Silvia de Santis and Dr. Santiago Canals, both from the Institute of Neurosciences UMH-CSIC (Alicante, Spain), has made it possible to visualize for the first time and in great detail brain inflammation using diffusion-weighted Magnetic Resonance Imaging.

27 May 2022

Researchers report novel interactions between the SARS-CoV-2 S protein and estrogen receptor alpha

Researchers profiled the binding sites of the entire SARS-CoV-2 spike protein sequence.

26 May 2022

Deep visual proteomics is redefining cancer diagnostics

In a recent study published in the journal Nature Biotechnology, researchers introduced deep visual proteomics (DVP), an amalgamation of artificial intelligence (AI) for image analysis and mass spectrometry (MS) for proteomic profiling of biological samples.

22 May 2022

In-depth characterization of the BA.2 versus BA.1 variant

In a recent study published in the journal Nature, researchers evaluated the pathogenicity and infectivity of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Omicron BA.2 variant in hamsters and mice.

19 May 2022

Scientists explore triggers associated with transplacental transmission of SARS-CoV-2

A new study examines the risk of fetal SARS-CoV-2 infection following infection of a pregnant mother with the virus.

17 May 2022

Free SARS-CoV-2 spike protein fragments may trigger platelet activation and clot formation in COVID-19

In a recent study under review in the Nature Portfolio journal and currently available on the Research Square* preprint server, researchers investigated the presence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike protein (SP) in the thrombi (or blood clots).

5 May 2022

Identification of a SARS-CoV-2 neutralizing human monoclonal antibody with a remarkable broad-spectrum neutralization and protection efficacy

Researchers identified a human monoclonal antibody (mAb), 87G7, with in vitro neutralizing activity against several SARS-CoV-2 VOCs, including Alpha, Beta, Gamma, Delta, and Omicron.

28 Apr 2022

A novel mouse model to test SARS-CoV-2 viral infection

In a recent study posted to the Research Square* preprint server, researchers developed a novel mouse model for testing infection by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2).

26 Apr 2022

Persistent loss of smell after COVID-19 associated with altered olfactory epithelial gene expression

Researchers performed histology of the olfactory epithelium for smell loss measurements in patients with post-acute sequelae of SARS-CoV-2 infection.

20 Apr 2022

Scientists find critical role for Hippo signaling pathway in COVID-19 pathogenesis

A recent article posted to the bioRxiv* preprint server illustrated that the activation of the Hippo signaling pathway upon severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection aids the host antiviral response.

11 Apr 2022

Prime-pull immunization of mice with novel subunit vaccine elicits mucosal immunity to prevent severe SARS CoV-2 infection

Researchers tested whether a subunit vaccine could generate mucosal immunity in mice and prevent SARS-CoV-2 infection and related pathology.

11 Apr 2022

S-Nitrosylation of ACE2 inhibits binding of SARS-CoV-2 spike protein

In a recent study posted to the bioRxiv* preprint server, researchers developed aminoadamantane nitrates compounds that inhibit the ion channels formed by the envelope (E) protein of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and enable targeted drug delivery of nitric oxide (NO)-related group for S-nitrosylation of host angiotensin-converting enzyme 2 (ACE2), which would inhibit ACE2 binding with the viral spike (S) protein and thereby inhibit viral replication in the host.

11 Apr 2022

Developing and manufacturing custom recombinant antibodies for R&D

In this interview, Dr. Linlin Zhang, technical specialist for Sino Biological Europe, discusses how Sino is expanding its product offerings into the European market and outlines its process for developing and manufacturing custom recombinant antibodies for their clients.

From Sino Biological Inc. 6 Apr 2022

Immunohistochemistry News and Research

Further Reading

Mice study unravels the role of T. denticola in Alzheimer's disease pathogenesis

The presence of residual SARS-CoV-2 antigens in post-convalescent tissues

Exploring virological profiles of recently emerged SARS-CoV-2 Omicron variants

Using diffusion-weighted MRI to visualize brain inflammation in vivo for the first time

Researchers report novel interactions between the SARS-CoV-2 S protein and estrogen receptor alpha

Deep visual proteomics is redefining cancer diagnostics

In-depth characterization of the BA.2 versus BA.1 variant

Scientists explore triggers associated with transplacental transmission of SARS-CoV-2

Free SARS-CoV-2 spike protein fragments may trigger platelet activation and clot formation in COVID-19

Identification of a SARS-CoV-2 neutralizing human monoclonal antibody with a remarkable broad-spectrum neutralization and protection efficacy

A novel mouse model to test SARS-CoV-2 viral infection

Persistent loss of smell after COVID-19 associated with altered olfactory epithelial gene expression

Scientists find critical role for Hippo signaling pathway in COVID-19 pathogenesis

Prime-pull immunization of mice with novel subunit vaccine elicits mucosal immunity to prevent severe SARS CoV-2 infection

S-Nitrosylation of ACE2 inhibits binding of SARS-CoV-2 spike protein

Developing and manufacturing custom recombinant antibodies for R&D

Study generates a picture of the myocardial transcriptional landscape of COVID-19

TMPRSS2 inhibitor found to be a novel and effective therapeutic option against pan-variant SARS-CoV-2 infections

Divalent SARS-CoV-2 fusion vaccine found to be effective in mice

Examining differences in neurological manifestations induced by SARS-CoV-2 variants in hamsters

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