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Scientists identify key molecular pathway that leads to depression

Scientists have identified the key molecular pathway leading to depression, revealing potential new targets for drug discovery, according to research led by King's College London's Institute of Psychiatry. The study, published today in Neuropsychopharmacology, reveals for the first time that the 'Hedgehog pathway' regulates how stress hormones, usually elevated during depression, reduce the number of brain cells.

6 Dec 2012

Viewpoints: Lame duck Congress shouldn't take on entitlement changes; New legal challenge to health law; 'Irrational vote' on disability pact

What we need in order to address this fiscal abyss is a Grand Bargain that addresses the two main drivers of our structural deficits: unsustainable social insurance programs, especially health care programs, and a complex, unfair, uncompetitive and inadequate tax system. But a lame duck Congress cannot and should not tackle comprehensive tax and social insurance reforms.

6 Dec 2012

Bio-Path to initiate BP-100-1.01 Phase I trial for treatment of two types of breast cancer

Bio-Path Holdings, Inc., a biotechnology company developing a liposomal delivery technology for nucleic acid cancer drugs, today announced it is initiating development of its lead cancer drug BP-100-1.01 (Liposomal Grb-2) to treat triple negative breast cancer (TNBC) and inflammatory breast cancer (IBC), two cancers characterized by formation of aggressive tumors and relatively high mortality rates.

6 Dec 2012

Electrotherapy not effective pain treatment in the aftermath of pancreatic surgery

Osteopathy may help reduce chronic pain and stiffness after thoracic surgery. However, electrotherapy is not effective pain treatment in the aftermath of pancreatic surgery. These are the findings of a thesis from Sahlgrenska Academy, University of Gothenburg, Sweden, that studied complementary and alternative therapies.

6 Dec 2012

Few new doctors choose primary care

Less than a quarter of new doctors are choosing primary care as their specialty, even after finishing residency programs focused on internal medicine, a new study reports.

6 Dec 2012

Johns Hopkins focuses on MRSA, motherhood in November-December 2012 research news brief

Johns Hopkins Nursing researchers focus on MRSA, motherhood, hospital stress, intimate partner violence, and more in the November-December 2012 research news brief.

6 Dec 2012

Maryland P3 Program can improve outcomes of patients with chronic diseases

A new program guide, published by the Centers for Disease Control and Prevention (CDC), features the Maryland Patients, Pharmacists, Partnerships (P3) as an effective model of how health care teams that include pharmacists can improve the outcomes of patients with chronic diseases.

6 Dec 2012

Case Western Reserve to receive funding through Healthy Growth grant program

Case Western Reserve University School of Medicine announced that it will receive funding through the Achieving Healthy Growth program within the Grand Challenges in Global Health initiative.

6 Dec 2012

Prescribing opioids lead to admissions for substance abuse treatment and deaths

A Viewpoint article published recently in the Journal of the American Medical Association suggests that the clinical practice of prescribing amphetamines, opioids, and benzodiazepines to treat chronic pain may be contributing to the increase in fatal drug overdoses and the likelihood that those drugs will be diverted to the illegal market.

6 Dec 2012

Rice bran offers promising cancer prevention properties

A recent University of Colorado Cancer Center review in the journal Advances in Nutrition shows that rice bran offers promising cancer prevention properties. Meanwhile, an ongoing clinical trial is testing the effectiveness of rice bran in preventing the recurrence of colon cancer.

6 Dec 2012

Tyk2 enzyme helps regulate obesity through differentiation of brown adipose tissue

Approximately 68 percent of U.S. adults are overweight or obese, according to the National Cancer Institute, which puts them at greater risk for developing cancer, cardiovascular disease, diabetes and a host of other chronic illnesses. But an international team of scientists led by Virginia Commonwealth University Massey Cancer Center researcher Andrew Larner, M.D., Ph.D., has successfully reversed obesity in mice by manipulating the production of an enzyme known as tyrosine-protein kinase-2 (Tyk2).

6 Dec 2012

Tenofovir DF safe and effective in treating adolescents with HBV

A recent clinical trial found that the adult antiviral drug, tenofovir disoproxil fumarate (tenofovir DF), is safe and effective in treating adolescents with hepatitis B virus (HBV). Trial results published in the December issue of Hepatology, a journal of the American Association for the Study of Liver Diseases (AASLD), show that tenofovir DF suppressed HBV in 89% of pediatric participants.

6 Dec 2012

Ponatinib offers new hope in drug-resistant leukemia

An investigational tyrosine kinase inhibitor, ponatinib, has shown high levels of activity in patients with chronic myeloid leukemia and Philadelphia chromosome-positive acute lymphoblastic leukemia.

5 Dec 2012

Nerve stimulation improves hand use in spinal cord injury patients

A method combining transcranial magnetic stimulation with electrical stimulation of peripheral nerves in the wrist temporarily improves hand use in spinal cord injury patients, show research findings published in Current Biology.

5 Dec 2012

Children with HIV more likely to develop atherosclerosis

Children with HIV have a 2.5 fold increased risk of atherosclerosis, according to research presented at EUROECHO and other Imaging Modalities 2012. Antiretroviral treatment, lipid lowering drugs and prevention with healthy lifestyles are needed to prevent early death from cardiovascular disease.

5 Dec 2012

USAID introduces 'first-ever' guidance on building resiliency

On Monday, USAID Administrator Rajiv Shah "announced the launch of the agency's first-ever policy and program guidance on Building Resilience to Recurrent Crisis during an event in Washington, D.C.," according to an USAID press release.

5 Dec 2012

Low-income people show poor adherence to Mediterranean diet

Recently the Mediterranean diet has achieved lots of distinctions, from the inclusion by the UNESCO in the Olympus of the World heritage list to a long series of dedicated congresses and meetings held everywhere in the globe with the aim of promoting its healthy properties against the most threatening diseases such as cardiovascular disease and tumors.

From Evident Corporation - Life Sciences 5 Dec 2012

Baxter enters definitive agreement to acquire Gambro

Baxter International Inc. has entered into a definitive agreement to acquire Gambro AB, a privately held dialysis product company based in Lund, Sweden, for total consideration of 26.5 billion SEK (approximately $4.0 billion USD at current exchange rates).

From Baxter International Inc. 5 Dec 2012

NOXXON commences NOX-H94 Phase IIa trial to treat anemia of chronic disease

NOXXON Pharma today announced the treatment of the first patients in a Phase IIa clinical trial of its anti-hepcidin Spiegelmer NOX-H94 to treat anemia associated with chronic disease.

5 Dec 2012

Study identifies factors that can predict postpartum pelvic girdle pain in working women

A new study of working women has identified factors during pregnancy and postpartum that can predict pain in the joints that comprise the pelvic girdle. While 90 percent of working women in the Netherlands return to work after the birth of their first child, health issues during the postpartum period often require sick leave. Chief among these health issues is pelvic girdle pain (PGP).

5 Dec 2012