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Blocking GSK3b enzyme can prevent bacterial-induced periodontal bone loss

A University of Louisville scientist has found a way to prevent inflammation and bone loss surrounding the teeth by blocking a natural signaling pathway of the enzyme GSK3b, which plays an important role in directing the immune response.

12 Sep 2012

CT shows promise in predicting COPD exacerbation risk

Measurement of the pulmonary artery-to-aorta ratio can predict the risk for exacerbations in patients with chronic obstructive pulmonary disease, particularly those that require hospitalization, say the authors of a US study.

11 Sep 2012

Nonsurgical treatment achieves periodontitis improvements regardless of smoking

Both smokers and nonsmokers with the chronic inflammatory disease periodontitis have significantly improved clinical markers, including probing depth and plaque index, after nonsurgical periodontal therapy, show study results.

11 Sep 2012

Half of all people of South Asian, African descent will develop diabetes by age 80

Half of all people of South Asian, African and African Caribbean descent will develop diabetes by age 80 according to a new study published today. The study is the first to reveal the full extent of ethnic differences in the risk of developing type 2 diabetes and also provides some answers as to the causes of the increased risk.

11 Sep 2012

KRAS gene mutation recruits second player to trigger pancreatic cancer

More than a cancer-causing gene is needed to trigger pancreatic cancer, a study led by Mayo Clinic has found. A second factor creates a "perfect storm" that allows tumors to form, the researchers say. The study, published in the Sept. 10 issue of Cancer Cell, overturns the current belief that a mutation in the KRAS oncogene is enough to initiate pancreatic cancer and unrestrained cell growth.

11 Sep 2012

Research focuses on how we can improve care and outcomes for patients with multimorbidity

A research review carried out by the HRB Centre for Primary Care Research, based in the Royal College of Surgeons in Ireland (RCSI) and published in this month's edition of the British Medical Journal (BMJ) has focused on how we can improve care and outcomes for patients with multimorbidity (co-existence of two or more long-terms health conditions in an individual).

11 Sep 2012

Pediatric pain: An interview with Lori Kozlowski

The pain experienced by the infants, children and adolescents in our study was the result of a broad range of medical and surgical conditions.

11 Sep 2012

Pergamum initiates LL-37 Phase I/II trial in hard-to-heal venous leg ulcers

Pergamum AB announced today that dosing has begun in a randomized Phase I/II trial of LL-37 for the treatment of patients with hard-to-heal venous leg ulcers.

11 Sep 2012

Phase III data for Suvorexant, an investigational insomnia medicine, announced

Merck (NYSE: MRK), known as MSD outside the United States and Canada, today announced new data for suvorexant, the investigational medicine Merck is developing for the treatment of insomnia. The new data are from one of the longest, continuously-dosed, placebo-controlled trials of a sleep medication ever conducted.

10 Sep 2012

Heptares uses StaR technology to solve structure of CRF-1 receptor

Heptares Therapeutics today announces that it has used its StaR technology to solve entirely in-house the first structure of a Family B sub-class G protein-coupled receptor (GPCR).

10 Sep 2012

New oral antiseptic spray effective in killing 99.9% of infectious airborne germs

University Hospitals Case Medical Center clinical researchers will present findings about a one-two punch to prevent colds and flu in San Francisco at the Interscience Conference on Antimicrobial Agents and Chemotherapy (ICAAC) on Sept. 9.

10 Sep 2012

Antibiotic treatment more effective than placebo in patients with mild-to-moderate COPD

Antibiotic treatment with amoxicillin/clavulanate improves moderate exacerbations in patients with mild-to-moderate chronic obstructive pulmonary disease (COPD) and significantly prolongs the time between exacerbations, according to a new study from researchers in Spain.

10 Sep 2012

Trevena to present TRV027 Phase 1 clinical data at 16th Annual Heart Failure Society of America Meeting

Trevena, Inc., the leader in the discovery of G-protein coupled receptor (GPCR) biased ligands, today announced that it is presenting a poster featuring Phase 1 clinical data on TRV027 at the 16th Annual Heart Failure Society of America Meeting being held in Seattle, WA, September 9th-12th. Trevena is developing TRV027 for the treatment of acute decompensated heart failure.

7 Sep 2012

Research roundup: Reducing risk in shared savings programs

The Design And Application Of Shared Savings Programs: Lessons From Early Adopters --"Shared savings programs reward providers for holding spending below specific targets, thus introducing a level of financial accountability not present in strictly volume-based payment models, such as fee-for-service," researchers write.

7 Sep 2012

Test to identify potentially deadly calcium deposits in tissues and blood vessels

A new test could help identify and treat individuals at risk of developing potentially deadly calcium deposits in their tissues and blood vessels, according to a study appearing in an upcoming issue of the Journal of the American Society of Nephrology. Heart disease is the number one killer of patients with chronic kidney disease (CKD), and vascular calcification is thought to play a major role.

7 Sep 2012

American troops with noise-induced hearing loss, tinnitus may benefit from novel strategies

Antioxidants, dietary supplements and high-tech brain imaging are among some of the novel strategies that may help detect, treat and even prevent noise-induced hearing loss and tinnitus among American troops, according to researchers at Henry Ford Hospital.

7 Sep 2012

Children and young patients with chronic HBV infection do have a protective immune response

Scientists from A*STAR's Singapore Institute for Clinical Sciences (SICS), together with clinical collaborators from London , discovered for the first time that children and young patients with chronic Hepatitis B Virus infection (HBV carriers) do have a protective immune response, contrary to current belief, and hence can be more suitable treatment candidates than previously considered.

7 Sep 2012

Parents' concern about melanoma does not make them keep their kids indoors

Pick your poison: sun exposure that leads to skin cancer or low physical activity that leads to obesity? In fact, a University of Colorado Cancer Center study published this week in the journal Preventing Chronic Disease shows that parents' concern about skin cancer doesn't make them keep their kids indoors.

7 Sep 2012

Study investigates effects of acidity on breast and pancreatic cancer cell lines

Researchers at Moffitt Cancer Center and colleagues at the University of South Florida and Wayne State University have discovered that tumor cell survival relies on adaptation to acidic conditions in the tumor microenvironment.

7 Sep 2012

Interleukin-18 plays a key role in inflammation

The naturally occurring cytokine interleukin-18, or IL-18, plays a key role in inflammation and has been implicated in serious inflammatory diseases for which the prognosis is poor and there are currently limited treatment options.

7 Sep 2012

Chronic News and Research

Blocking GSK3b enzyme can prevent bacterial-induced periodontal bone loss

CT shows promise in predicting COPD exacerbation risk

Nonsurgical treatment achieves periodontitis improvements regardless of smoking

Half of all people of South Asian, African descent will develop diabetes by age 80

KRAS gene mutation recruits second player to trigger pancreatic cancer

Research focuses on how we can improve care and outcomes for patients with multimorbidity

Pediatric pain: An interview with Lori Kozlowski

Pergamum initiates LL-37 Phase I/II trial in hard-to-heal venous leg ulcers

Phase III data for Suvorexant, an investigational insomnia medicine, announced

Heptares uses StaR technology to solve structure of CRF-1 receptor

New oral antiseptic spray effective in killing 99.9% of infectious airborne germs

Antibiotic treatment more effective than placebo in patients with mild-to-moderate COPD

Trevena to present TRV027 Phase 1 clinical data at 16th Annual Heart Failure Society of America Meeting

Research roundup: Reducing risk in shared savings programs

Test to identify potentially deadly calcium deposits in tissues and blood vessels

American troops with noise-induced hearing loss, tinnitus may benefit from novel strategies

Children and young patients with chronic HBV infection do have a protective immune response

Parents' concern about melanoma does not make them keep their kids indoors

Study investigates effects of acidity on breast and pancreatic cancer cell lines

Interleukin-18 plays a key role in inflammation

Improving healthcare sustainability through carbon data

A New Approach to Preventing Bladder Cancer Recurrence

Bringing real-time analytics to downstream bioprocess monitoring

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