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Acorda commences AMPYRA clinical study for post-stoke deficits

Acorda Therapeutics, Inc. today announced that the first patient has been enrolled in a proof-of-concept study exploring the use of AMPYRA(dalfampridine) Extended Release Tablets, 10 mg in treating patients who have post-stroke deficits.

13 Jun 2012

First Edition: June 12, 2012

Today's headlines include news about the pressure health costs are placing on state budgets.

12 Jun 2012

Scientists establish link between autoimmune diseases and nanoparticles

New groundbreaking research by scientists at Trinity College Dublin has found that exposure to nanoparticles can have a serious impact on health, linking it to rheumatoid arthritis and the development of other serious autoimmune diseases.

12 Jun 2012

Sleep apnea may speed-up kidney decline

Patients with chronic kidney disease are commonly exposed to nocturnal hypoxia that may increase the rate of decline in kidney function, Canadian researchers report.

12 Jun 2012

Uncertainty over efficacy of clopidogrel in hemolytic uremic syndrome

Clinical outcomes for children hospitalized with diarrhea-associated hemolytic uremic syndrome are comparable between those treated with clopidogrel and those who are not, show study findings.

12 Jun 2012

Smoking may increase risk of death in older patients

An analysis of available medical literature suggests smoking was linked to increased mortality in older patients and that smoking cessation was associated with reduced mortality at an older age, according to a report published in the June 11 issue of Archives of Internal Medicine, a JAMA Network publication.

12 Jun 2012

Study shows how infections provoke tissues into becoming cancerous

One of the biggest risk factors for liver, colon or stomach cancer is chronic inflammation of those organs, often caused by viral or bacterial infections. A new study from MIT offers the most comprehensive look yet at how such infections provoke tissues into becoming cancerous.

12 Jun 2012

Sucrose and menthol act independently to reduce coughing

Millions of Americans reach for their cough drops or syrup at the first sign of a cough. However, scientists are unsure if and how these popular remedies work. Now, new findings from the Monell Center suggest that sucrose and menthol, ingredients commonly regarded as flavorings in these preparations, each act independently to reduce coughing.

12 Jun 2012

Rheumatoid arthritis infection risk predicted by RABBIT

The RABBIT risk score can predict the likelihood of serious infection in rheumatoid arthritis patients using tumor necrosis factor-alpha inhibitors and disease-modifying antirheumatic drugs, research confirms.

11 Jun 2012

Familial predisposition ‘modestly’ affects alcoholic liver disease risk

Environmental factors appear to be the main influence on the risk for alcoholic liver disease, say researchers who found little evidence for familial predisposition to the condition.

11 Jun 2012

Theramine may reduce chronic low back pain

Physician Therapeutics, Inc., a division of Targeted Medical Pharma, Inc., a specialty pharmaceutical company that develops and distributes prescription medical foods to physicians, pharmacies and skilled nursing facilities, published results from a clinical trial of the company's proprietary medical food Theramine.

11 Jun 2012

Powerful new tools can study glycans’ function

Scientists at The Scripps Research Institute have developed chemical compounds that can make key modifications to common sugar molecules ("glycans"), which are found on the surface of all cells in our body. The new study presents powerful new tools for studying these molecules' function, for example in cell signaling and immunity, and for investigating new treatments for chronic inflammation, autoimmune diseases, cancer metastasis, and related conditions.

11 Jun 2012

Study reviews data on influence of contralateral carotid occlusion on CEA and CAS

A new study, presented at the 66th Vascular Annual Meeting presented by the Society for Vascular Surgery (SVS) reviewed data on the influence of contralateral carotid occlusion (CCO) on carotid endarterectomy (CEA) and carotid artery stenting (CAS) for which there is a paucity of conflicting data.

11 Jun 2012

Study examines factors linked with survival after CEA in patients with asymptomatic ICA stenosis

While carotid endarterectomy (CEA) is performed to prevent stroke, long-term survival is essential to ensure benefit, especially in asymptomatic patients. A new study presented at the 66th Vascular Annual Meeting presented by the Society for Vascular Surgery today examined patient factors associated with 5-year survival following CEA in patients with asymptomatic internal carotid artery (ICA) stenosis.

11 Jun 2012

Poor long-term physical and mental health for many adolescent and young adult cancer survivors

A new analysis has found that many adolescent and young adult cancer survivors have unhealthy behaviors, chronic medical conditions, a poor quality of life, and significant barriers to health care access. Published early online in CANCER, a peer-reviewed journal of the American Cancer Society, the study indicates that greater efforts are needed to provide quality follow-up care to adolescent and young adult cancer survivors and to encourage them to live more healthily.

11 Jun 2012

Amylin, Alkermes announce results from BYDUREON clinical study on type 2 diabetes

Amylin Pharmaceuticals, Inc. and Alkermes plc today announced results from the long-term extension of the DURATION-1 study, which showed that BYDUREON (exenatide extended-release for injectable suspension), the first and only once-weekly treatment for type 2 diabetes, was associated with clinically significant and sustained improvements in glycemic control during four years of treatment in adults with type 2 diabetes.

11 Jun 2012

First study to use simulated driving tests on medical staff returning home after night shift

The drowsiness experienced by medical staff who have been on night duty can make their driving dangerous, French researchers have found.

11 Jun 2012

Lilly, Boehringer Ingelheim announce results from linagliptin Phase III trial on T2D

Boehringer Ingelheim and Eli Lilly and Company presented results from a randomised Phase III clinical trial and a post-hoc analysis for linagliptin at ADA.

11 Jun 2012

Majority of African-American patients with hypertension suffer from hidden heart disease

A Wayne State University School of Medicine study has found that an overwhelming majority of African-American patients with hypertension also suffered hidden heart disease caused by high blood pressure even though they displayed no symptoms.

11 Jun 2012

ADAM28 inhibits VWF-mediated cancer cell apoptosis and enhances lung metastases

ADAM28, a metalloproteinase belonging to the ADAM gene family, cleaves the von Willebrand factor (VWF) and inhibits VWF-mediated cancer cell apoptosis, thereby enhancing lung metastases, so inhibiting its expression gives a substantial reduction in lung metastases, according to a study published June 8 in the Journal of The National Cancer Institute.

11 Jun 2012