MERS CoV News and Research

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In recent history, we have witnessed the emergence of several different life-threatening viruses. In addition to causing serious public health concerns around the globe, they have been responsible for significant human morbidity and mortality. Modern life that entails uncurtailed travel of humans and goods means that initially localized outbreaks may pose a risk of transmission anywhere in the world.

A mucoadhesive polymer with anti-SARS-COV-2 activity in vitro and in vivo

The team has evaluated a low molecular weight chitosan derivative as a candidate preventing the viral entry into mammalian nasal epithelial cells to limit the spread of COVID-19.

12 Oct 2021

New compound can prevent SARS-CoV-2 and related coronaviruses from entering cells

Scientists at Washington University School of Medicine in St. Louis have developed a compound that prevents SARS-CoV-2 and related coronaviruses from entering cells.

11 Oct 2021

Durability of immunity to SARS-CoV-2 reinfection

The current study used data on the durability of immunity among evolutionarily close coronavirus relatives of SARS-CoV-2 to estimate times to reinfection.

6 Oct 2021

Key lessons from COVID-19 pandemic for scientific and clinical communities

In a paper published in the journal Cell, researchers have investigated and criticized clinical care management and drug administration within the pandemic.

4 Oct 2021

Antiviral activity of wheat germ Agglutinin against SARS-CoV-2

A new study reports the antiviral activity of WGA against SARS-CoV-2 and its two Variants of Concern - Alpha and Beta.

4 Oct 2021

Using a new public antibody to understand SARS-CoV-2 neutralization

SARS-CoV-2 infects host cells by binding to the angiotensin convertase 2 receptor (ACE2) on the cell surface through its trimeric spike (S) protein. SARS-CoV enters host human cells through endosomes, while SARS-CoV-2 enters through the cell surface and endosomes. The present study published in the journal “Cell Reports” aimed to understand the mechanisms of SARS-CoV-2 antibody neutralization to facilitate the development of therapeutic interventions for COVID-19.

4 Oct 2021

Enveloped virus-like particle based vaccines potentially broaden immunity against SARS-CoV-2 variants

A new preprint describes promising results with a novel vaccine candidate designed to improve the breadth of neutralization.

1 Oct 2021

SARS-CoV-2 infection aided by antibody-dependent enhancement

The coronavirus disease 2019 (COVID-19) pandemic has raised concerns about the detrimental effects of antibodies. Antibody-dependent enhancement (ADE) of infection is one of the biggest concerns in terms of not only the antibody reaction to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) upon reinfection with the virus but also the reaction to COVID-19 vaccines.

30 Sep 2021

Human coronavirus replicates in bats without using the spike protein

Researchers in Singapore have conducted a study showing active replication of a human coronavirus in bats that occurred without the viral spike protein binding to host cell receptors.

28 Sep 2021

The role of heating, ventilation, and air-conditioning in virus transmission, including SARS-CoV-2

A new study provides an overview of reviews to identify previous systematic reviews on HVAC systems and airborne transmission of infectious agents.

28 Sep 2021

NIAID awards approximately $36.3 million to fuel vaccine research for coronaviruses

The National Institute of Allergy and Infectious Diseases, part of the National Institutes of Health, has awarded approximately $36.3 million to three academic institutions to conduct research to develop vaccines to protect against multiple types of coronaviruses and viral variants.

28 Sep 2021

A review of drugs harmful in COVID-19

In a new study, researchers investigate a number of drugs that are believed to potentially worsen outcomes in patients with COVID-19.

26 Sep 2021

Potential covalent SARS-CoV-2 spike protein inhibitors

There remains a significant need for new and effective drugs that can be used to treat COVID-19.

23 Sep 2021

Scientists hypothesize SARS-CoV-2 cryptically circulating among humans before the current outbreak

As nations begin to recover, researchers from the National Taiwan University and Academia Sinica in Taipei have been looking to identify the changes the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) underwent over the course of the pandemic in order to better understand why the disease showed such virulence.

20 Sep 2021

Scientists simulate SARS-CoV-2 virion envelope using Martini 3

A new study proposes an integrative computational approach to model the structure of the SARS-CoV-2 envelope.

20 Sep 2021

Nanoparticles-assisted delivery of antiviral-siRNA for treatment of COVID-19

A review aimed to determine the potential of siRNA as a potential COVID-19 treatment by reviewing the currently available literature.

10 Sep 2021

Potential pancoronavirus fusion inhibitors that are effective against SARS-CoV-2 variants

A new study successfully identifies a series of inhibitors that possesses pancoronavirus activity against SARS-CoV, SARS-CoV-2, and MERS-CoV.

7 Sep 2021

SARS-CoV-2 fusion peptides play distinct roles according to neutron scattering

A new study determines the physical and thermodynamic events associated with the interactions that lead to the fusion between SARS-CoV-2 and the host.

5 Sep 2021

The tale of mRNA vaccines: Turning calamity into opportunity

In a review paper published in the journal Nature Reviews, researchers from Carnegie Mellon University and the University of Pennsylvania have described the underlying technologies for mRNA vaccines and their future prospects with improved delivery systems and applications in diseases beyond the ongoing COVID-19 pandemic.

31 Aug 2021

COVID-19 pandemic illuminates the importance of airborne transmission of respiratory viruses

SARS-CoV-2, the virus behind today's global coronavirus pandemic, spreads primarily by inhalation of virus-laden aerosols at both short and long ranges - and a comprehensive new assessment of respiratory viruses finds that many others probably do as well.

27 Aug 2021