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Adaptive platform trial tests multiple treatments for traumatic brain injury

Traumatic brain injury (TBI) results in close to 70,000 deaths in the United States every year, and it is the cause of long-term physical, cognitive and mental disability in 5 million Americans. But despite three decades of work, treatments are sorely lacking.

19 Sep 2024

Brain measurements prove more accurate in predicting mild cognitive impairment

University of Oklahoma researchers recently published a study showing that several measurements of the brain, including blood flow and the brain's ability to compensate for the lack of it, are better predictors of mild cognitive impairment than risk factors like hypertension and high cholesterol.

16 Sep 2024

Heatwaves linked to increased seizures in epilepsy patients

Heatwaves can worsen abnormal excitability of the brain in people with epilepsy, finds a new small-scale patient study by clinical scientists at UCL.

11 Sep 2024

New dye technique allows for transparent skin imaging in live mice

Seeing what's going on inside a body is never easy. While technologies like CT scans, X-rays, MRIs, and microscopy can provide insights, the images are rarely completely clear and can come with side effects like radiation exposure.

5 Sep 2024

Hybrid neuron-glia cells found in glioma may impact tumor growth

Researchers at Baylor College of Medicine and the Jan and Dan Duncan Neurological Research Institute at Texas Children's Hospital have uncovered a new cell type in the human brain.

5 Sep 2024

Research uncovers unexpected origin of ataxia outside the cerebellum

A new study by the University of Turku and Turku University Hospital in Finland investigated the origin of ataxia in the brain of patients with stroke.

5 Sep 2024

Understanding the origins of spontaneous neural activity

A new study, published in Nature Communications this week, led by Jake Gavenas PhD, while he was a PhD student at the Brain Institute at Chapman University, and co-authored by two faculty members of the Brain Institute, Uri Maoz and Aaron Schurger, examines how the brain initiates spontaneous actions. In addition to demonstrating how spontaneous action emerges without environmental input, this study has implications for the origins of slow ramping of neural activity before movement onset - a commonly-observed but poorly understood phenomenon.

5 Sep 2024

New immunotherapy approach shows promise for minimizing spinal cord injury damage

WashU Medicine researchers have designed, in mice, an approach to minimizing the damage from a spinal cord injury through the use of engineered immune cells.

4 Sep 2024

Sports concussions may not be related to long-term cognitive risks for non-professional athletes

Sports-related concussions (SRC) may not be associated with long-term cognitive risks for non-professional athletes, a study led by a UNSW medical researcher suggests.

4 Sep 2024

Introducing a blood-based test for minimally invasive detection of IDH1 mutant gliomas

Glioma represents the most common central nervous system cancer in adults. The current classification scheme uses molecular alterations, particularly IDH1.R132H, to stratify lesions into distinct prognostic groups.

30 Aug 2024

Increased mental health risks in patients with brain aneurysms

Among people who had aneurysms (weakened areas in brain blood vessels), the risk of developing a mental health condition was higher than among peers without an aneurysm.

26 Aug 2024

Aceneuramic acid drug receives approval for treatment of patients with GNE myopathy

In order to treat an underserved population of patients with a rare condition whose muscles gradually become weaker until they can no longer walk, a team of researchers across Japan have completed a clinical study to confirm the safety of long-term administration of a therapeutic drug.

20 Aug 2024

Decline in psychological wellbeing may signal early mild cognitive impairment

Feeling that your life lacks purpose and that there are few opportunities for personal growth in older age may precede the development of mild cognitive impairment (MCI), a frequent precursor of dementia, suggests research published online in the Journal of Neurology Neurosurgery & Psychiatry.

13 Aug 2024

Study shows how Western classical music elicits positive effects on the brain

Whether Bach, Beethoven, or Mozart, it's widely recognized that classical music can affect a person's mood.

9 Aug 2024

Houston Methodist pioneers new technique for targeted drug delivery to the brain

Houston Methodist researchers have discovered a more accurate and timely way to deliver life-saving drug therapies to the brain, laying the groundwork for more effective treatment of brain tumors and other neurological diseases.

8 Aug 2024

Drug shows new promise in treating breast cancer with brain metastases or recurrent glioblastoma

A drug effective in treating breast cancer shows new promise in addressing breast cancer with brain metastases or recurrent glioblastoma, as reported by results of a prospective window-of-opportunity trial at the University of Texas Health Science Center at San Antonio (UT Health San Antonio).

8 Aug 2024

METRNL protein identified as key player in cancer progression

A protein called Meteorin-like (METRNL) in the tumor microenvironment saps energy from T cells, thereby severely limiting their ability to fight cancer, according to new research directed by investigators at the Johns Hopkins University School of Medicine and the Johns Hopkins Kimmel Cancer Center and its Bloomberg~Kimmel Institute for Cancer Immunotherapy. Finding ways to block the effects of METRNL signaling on tumor-infiltrating T cells may allow these immune cells to regain the energy necessary to eliminate tumors.

7 Aug 2024

Elevated metal levels in plasma and urine associated with greater ALS risk and shorter survival

People with higher levels of metals found in their blood and urine may be more likely to be diagnosed with - and die from - amyotrophic lateral sclerosis, or ALS, a University of Michigan-led study suggests.

6 Aug 2024

UCLA launches groundbreaking clinical trial for vaccine targeting aggressive pediatric brain cancer

In an effort to combat one of the most lethal forms of pediatric brain cancer, researchers at the UCLA Health Jonsson Comprehensive Cancer Center are launching a first-of-its-kind clinical trial to evaluate the safety and effectiveness of a cancer vaccine targeting H3 G34-mutant diffuse hemispheric glioma, a highly aggressive brain tumor that is typically found in adolescents and young adults.

5 Aug 2024

Vanderbilt to introduce focused ultrasound for treating essential tremor and Parkinson's disease

The movement disorder neurology and neurosurgery team at Vanderbilt University Medical Center is set to add focused ultrasound treatment (FUS) as a new tool in the treatment of essential tremor and Parkinson's disease.

1 Aug 2024

Neurosurgery News and Research

Adaptive platform trial tests multiple treatments for traumatic brain injury

Brain measurements prove more accurate in predicting mild cognitive impairment

Heatwaves linked to increased seizures in epilepsy patients

New dye technique allows for transparent skin imaging in live mice

Hybrid neuron-glia cells found in glioma may impact tumor growth

Research uncovers unexpected origin of ataxia outside the cerebellum

Understanding the origins of spontaneous neural activity

New immunotherapy approach shows promise for minimizing spinal cord injury damage

Sports concussions may not be related to long-term cognitive risks for non-professional athletes

Introducing a blood-based test for minimally invasive detection of IDH1 mutant gliomas

Increased mental health risks in patients with brain aneurysms

Aceneuramic acid drug receives approval for treatment of patients with GNE myopathy

Decline in psychological wellbeing may signal early mild cognitive impairment

Study shows how Western classical music elicits positive effects on the brain

Houston Methodist pioneers new technique for targeted drug delivery to the brain

Drug shows new promise in treating breast cancer with brain metastases or recurrent glioblastoma

METRNL protein identified as key player in cancer progression

Elevated metal levels in plasma and urine associated with greater ALS risk and shorter survival

UCLA launches groundbreaking clinical trial for vaccine targeting aggressive pediatric brain cancer

Vanderbilt to introduce focused ultrasound for treating essential tremor and Parkinson's disease

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