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Group-based and online counselling reduces diabetes risk in high-risk men

Group-based and online lifestyle counselling can support middle-aged and older men in making health-promoting dietary changes. These dietary changes, in turn, reduce the risk of type 2 diabetes, especially among men with a high genetic risk, a study conducted at the University of Eastern Finland shows.

30 Sep 2025

Study shows how early-life epigenetic 'memory' can influence adult brain inflammation

Why do some people remain healthy through childhood yet become more vulnerable to brain disorders such as dementia later in life? A KAIST (President Kwang Hyung Lee) -led team has uncovered a key part of the answer: a developmental 'switch' in astrocytes—the brain's most abundant support cells that shapes how strongly the brain's immune system reacts in adulthood.

25 Sep 2025

UPR modulators show promise in treating cancer-related bone disease

Before a chain of amino acids can become an active and useful protein, it must be processed and folded into the appropriate conformation.

25 Sep 2025

Targeting TGF-β signaling as a strategy to treat liver fibrosis

Liver fibrosis, a pathological scarring process resulting from chronic liver injury, represents a significant global health burden due to its potential progression to cirrhosis and hepatocellular carcinoma.

25 Sep 2025

How food choices and cooking methods drive brain inflammation and disease

Researchers reviewing evidence in NeuroSci show how dietary AGEs and their interaction with RAGE drive oxidative stress, inflammation, and neurodegeneration. They highlight how cooking methods and diet choices could lower AGE burden and protect brain health, while calling for rigorous clinical trials.

24 Sep 2025

HIV protein Tat found to increase vulnerability to tuberculosis

According to the World Health Organization, tuberculosis accounts for one in three deaths among people living with HIV.

18 Sep 2025

Loss of key Y chromosome gene causes infertility in male mice

In a new study conducted at the University of Hawaiʻi at Mānoa, researchers from the John A. Burns School of Medicine (JABSOM) have shown that the loss of a key male fertility gene leads to infertility and changes expression of hundreds of other important genes.

17 Sep 2025

Study reveals how centenarians preserve youthful immune defenses

Researchers mapped immune cells from centenarians, their offspring, and younger controls across three cohorts using multi-omics single-cell profiling. They found that centenarians retain leaner helper pools but have enhanced cytotoxic and NK cell programs, along with reinforced NK–T communication networks.

15 Sep 2025

An AI assistant can interpret those lab results for you

When Judith Miller had routine blood work done in July, she got a phone alert the same day that her lab results were posted online.

15 Sep 2025

Female-specific mechanism enhances heat production in brown fat

Higher activity of PGC-1α enables brown fat cells in females to thermogenic activity and energy expenditure compared to males, reveals a study conducted in Japan.

12 Sep 2025

RAB26 identified as a critical regulator of prostate cancer aggressiveness

Prostate cancer (PCa) is one of the most common malignant tumors in men worldwide. While early detection has improved patient outcomes, effective therapies for advanced disease remain limited.

11 Sep 2025

Researchers reveal why no level of air pollution is safe for respiratory health

A review in the Journal of Clinical Investigation shows how particulate matter damages the lungs through oxidative stress, inflammation, and immune disruption. It links air pollution to asthma, COPD, lung cancer, infections, and millions of premature deaths, with no safe exposure threshold.

9 Sep 2025

Exploring whether chemotherapy disrupts biological clock in the brain to impair circadian rhythms

During and after chemotherapy, nearly half of cancer patients endure circadian rhythm disruptions, which worsens treatment side effects.

9 Sep 2025

New method advances RNA velocity analysis with spatial and multi batch integration

Essentially all cells in an organism's body have the same genetic blueprint, or genome, but the set of genes that are actively expressed at any given time in a cell determines what type of cell it will be and its function.

5 Sep 2025

Unlocking the secrets of oral bacteria to fight tooth decay

If Wenjun Zhang has her way, no one will ever have to brush or floss again.

5 Sep 2025

New insights into pathogenic T cells offer hope for Crohn's disease treatment

The research group led by Drs. Mitsuru Arase, Mari Murakami, and Prof. Kiyoshi Takeda (Graduate School of Medicine/ Immunology Frontier Research Center at The University of Osaka) revealed that transcription factors RUNX2 and BHLHE40 play crucial roles in inducing T cells involved in Crohn's disease.

4 Sep 2025