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Study uncovers new mechanism of action in a first-line drug for diabetes

For decades, metformin has been the first-line drug in the treatment of type 2 diabetes, lowering blood glucose levels by inhibiting glucose production in the liver. Metformin also improves glucose uptake and use by muscle tissue.

23 Oct 2018

Patients with severe asthma may benefit from newly developed targeted treatments

In a novel study, researchers succeeded in identifying patients with a form of severe asthma (type 2 endotype) by measuring periostin concentrations in their airways.

23 Oct 2018

New discovery may lead to better treatment options for pancreatic cancer patients

Pancreatic cancer is one of the most difficult cancers to treat and is a leading cause of cancer-related deaths. Now, Sidney Kimmel Cancer Center - Jefferson Health and Lankenau Institute for Medical Research scientists find that a gene involved in the immune system called IDO2 plays a significant role in pancreatic ductal adenocarcinoma, the most common type of pancreatic cancer.

23 Oct 2018

Common antibodies associated with myocardial infarction

Levels of antiphospholipid antibodies, which are associated with rheumatic diseases, are also elevated in myocardial infarction without any autoimmune co-morbidity, a study from Karolinska Institutet in Sweden published in The Annals of Internal Medicine reports.

23 Oct 2018

New approach may lead to better diagnostic techniques for autoimmune disorders

If we really want to know how our body's cells work - or don't work, in the case of disease - we might need to look beyond their genes and even beyond the proteins they are made of.

23 Oct 2018

Researchers identify common genetic connection in lung conditions

An international research team led by members of the University of Colorado School of Medicine faculty has identified a genetic connection between rheumatoid arthritis-associated interstitial lung disease and idiopathic pulmonary fibrosis.

22 Oct 2018

Innovative strategy opens up new avenue of treatment for anthrax infections

A team led by Professor Arne Skerra at the Technical University of Munich has developed an innovative strategy for preventing the anthrax bacterium from absorbing iron, which is crucial for its survival.

22 Oct 2018

Researchers develop promising targeted strategy to treat chemo-resistant blood cancer

Researchers from The Ottawa Hospital and the University of Ottawa have developed a promising targeted strategy to treat chemotherapy-resistant acute myeloid leukemia and a diagnostic test to determine which AML patients would most likely benefit from this treatment.

22 Oct 2018

Aspirin may be effective in preventing blood clots after knee replacement

When it comes to preventing blood clots after a knee replacement, good old aspirin may be just as effective as newer, more expensive drugs.

22 Oct 2018

People with periodontal disease less likely to reach healthy blood pressure ranges

People with high blood pressure taking medication for their condition are more likely to benefit from the therapy if they have good oral health, according to new research in the American Heart Association's journal Hypertension.

22 Oct 2018

Primary care doctors ‘not doing enough’ to curb STDs

Julie Lopez, 21, has been tested regularly for sexually transmitted diseases since she was a teenager. But when Lopez first asked her primary care doctor about screening, he reacted with surprise, she said.

22 Oct 2018

Duration of respiratory disturbances may better predict mortality risk from OSA

How long a person with obstructive sleep apnea stops breathing may be a better predictor of mortality risk from OSA than the number of times they stop breathing, according to new research published online in the American Thoracic Society’s American Journal of Respiratory and Critical Care Medicine.

22 Oct 2018

FOTIVDA expected to be included in new ESMO guidelines for advanced renal cell carcinoma

EUSA Pharma welcomes the news that FOTIVDA (tivozanib) is expected to be included in the upcoming European Society of Medical Oncology clinical practice guidelines for advanced renal cell carcinoma, anticipated to be published at the end of this year.

22 Oct 2018

Genentech’s combination therapy improves outcome in patients with non-squamous non-small cell lung cancer

Genentech, a member of the Roche Group, today announced positive results from the Phase III IMpower130 study of Tecentriq (atezolizumab) plus chemotherapy (carboplatin and Abraxane® [albumin-bound paclitaxel; nab-paclitaxel]) for the initial (first-line) treatment of people with previously untreated metastatic non-squamous non-small cell lung cancer.

22 Oct 2018

Takeda presents vedolizumab phase 3 VISIBLE 1 trial results for treatment of moderately to severely active ulcerative colitis

Takeda Pharmaceutical Company Limited today announced results from the phase 3 VISIBLE 1 clinical trial evaluating the efficacy and safety of an investigational subcutaneous formulation of the gut-selective biologic vedolizumab for maintenance therapy in adult patients with moderately to severely active ulcerative colitis who achieved clinical response* at week 6 following two doses of open-label vedolizumab intravenous induction therapy.

22 Oct 2018

Pfizer announces PALOMA-3 trial results in patients with HR+, HER2- metastatic breast cancer

Pfizer Inc. today announced detailed overall survival data from the PALOMA-3 trial, which evaluated IBRANCE (palbociclib) in combination with fulvestrant compared to placebo plus fulvestrant in women with hormone receptor-positive (HR+), human epidermal growth factor receptor 2-negative (HER2-) metastatic breast cancer whose disease progressed on or after prior endocrine therapy.

22 Oct 2018

LYNPARZA Phase III SOLO-1 results show improved outcome for patients with advanced BRCA-mutated ovarian cancer

AstraZeneca and Merck & Co., Inc., Kenilworth, N.J., today announced detailed results from the Phase III SOLO-1 trial testing LYNPARZA (olaparib) 300 mg tablets twice-daily as a maintenance treatment for patients with newly diagnosed advanced BRCA-mutated ovarian cancer who were in complete or partial response following 1st-line standard platinum-based chemotherapy.

22 Oct 2018

Free phone app helps low-income obese patients to lose weight

With the help of a free phone app, low-income obese patients with signs of cardiovascular risk lost a clinically meaningful amount of weight, finds new research from Duke University.

22 Oct 2018

New 3D bioprinting technique shows potential for artificial tissue fabrication

University of Colorado Boulder engineers have developed a 3D printing technique that allows for localized control of an object's firmness, opening up new biomedical avenues that could one day include artificial arteries and organ tissue.

22 Oct 2018

FDA approves update to Rituxan label to include information on treatment of rare forms of vasculitis

Genentech, a member of the Roche Group, announced today that the U.S. Food and Drug Administration has approved an update to the Rituxan® (rituximab) label to include information on follow up treatment of adult patients with Granulomatosis with Polyangiitis and Microscopic Polyangiitis who have achieved disease control with induction treatment.

22 Oct 2018

Blood News and Research

Study uncovers new mechanism of action in a first-line drug for diabetes

Patients with severe asthma may benefit from newly developed targeted treatments

New discovery may lead to better treatment options for pancreatic cancer patients

Common antibodies associated with myocardial infarction

New approach may lead to better diagnostic techniques for autoimmune disorders

Researchers identify common genetic connection in lung conditions

Innovative strategy opens up new avenue of treatment for anthrax infections

Researchers develop promising targeted strategy to treat chemo-resistant blood cancer

Aspirin may be effective in preventing blood clots after knee replacement

People with periodontal disease less likely to reach healthy blood pressure ranges

Primary care doctors ‘not doing enough’ to curb STDs

Duration of respiratory disturbances may better predict mortality risk from OSA

FOTIVDA expected to be included in new ESMO guidelines for advanced renal cell carcinoma

Genentech’s combination therapy improves outcome in patients with non-squamous non-small cell lung cancer

Takeda presents vedolizumab phase 3 VISIBLE 1 trial results for treatment of moderately to severely active ulcerative colitis

Pfizer announces PALOMA-3 trial results in patients with HR+, HER2- metastatic breast cancer

LYNPARZA Phase III SOLO-1 results show improved outcome for patients with advanced BRCA-mutated ovarian cancer

Free phone app helps low-income obese patients to lose weight

New 3D bioprinting technique shows potential for artificial tissue fabrication

FDA approves update to Rituxan label to include information on treatment of rare forms of vasculitis

A New Approach to Preventing Bladder Cancer Recurrence

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

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