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Cell-to-cell contact helps in spreading SARS-CoV-2, finds study

People aren’t the only ones who should be social distancing — new research shows our cells need to as well. Researchers from Ohio State University in Columbus, Ohio, USA, used in-culture techniques to confirm SARS-CoV-2 transmission via cell-to-cell contact.

8 Jun 2021

NIH researchers find that the SARS-CoV-2 Nsp15’s uridine cleavage can evade the immune response

Research conducted by scientists at the National Institutes of Health in the USA shows that Nsp15 targets uridines (U). Following detection of U, Nsp15 can then further cleave a broad spectrum of RNA substrates.

8 Jun 2021

Immunomodulatory therapies for nephrological autoimmune diseases may help treat severe COVID-19

Various viruses and bacteria have long been known to cause autoimmune diseases where there is such a predisposition. This phenomenon also seems to play a major role in SARS-CoV-2, especially in severe courses.

8 Jun 2021

NIH researchers identify novel small molecule inhibitors of SARS-CoV-2 variants

A team of scientists from the National Institutes of Health (NIH), USA, has recently identified six novel small molecule inhibitors of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and its variants. The study is currently available on the bioRxiv* preprint server.

8 Jun 2021

New chip mimicking bovine endometrium could play key role in cattle’s pregnancy success

To investigate factors that can jeopardize pregnancy success in cattle, researchers at the University of São Paulo (USP) in Brazil used a kind of chip to mimic the environment of the endometrium, the tissue that lines the inside of the uterus.

8 Jun 2021

Study offers a deeper understanding of the molecular basis for schizophrenia

A study conducted by a group of Brazilian researchers contributes to a deeper understanding of the molecular basis for schizophrenia, and potentially to the development of more specific and effective treatments for the disease.

8 Jun 2021

Natural products show promise against COVID-19 via iron chelation

Researchers at the University of Catania in Italy investigated whether natural compounds could prevent disease progression. Their study published in the Journal of Clinical Medicine found that iron chelators and protease inhibitors can counteract SARS-CoV-2 infection.

7 Jun 2021

Redhill Biopharma announces completion of enrollment for oral opaganib phase 2/3 COVID-19 study

RedHill Biopharma Ltd., a specialty biopharmaceutical company, today announced that it has completed enrollment and randomized the last patient in the global Phase 2/3 study with opaganib (Yeliva, ABC294640) in patients hospitalized with severe COVID-19 pneumonia (NCT04467840).

7 Jun 2021

Genome-scale CRISPR screens pinpoint promising antiviral compounds against SARS-CoV-2

In a recent research paper currently available on the bioRxiv* preprint server, scientists in the US used genome-scale CRISPR knockout screens to identify factors that promote infection with the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), revealing the potential for broad-spectrum activity across the coronavirus family.

7 Jun 2021

Researchers identify a bacterium with anti-SARS-CoV-2 activity in vitro: Dolosigranulum pigrum

As intensive efforts are on to counter the virus, a new study by an international team of researchers reports the unexpected success of a bacterium in modulating the immune response in the airway and protecting the cells against infection with this virus.

7 Jun 2021

The great promise of antiviral peptides against SARS-CoV-2

A new study, recently published in the journal Viruses, describes the impressive evidence for the role of antimicrobial peptidse (AMPs) in the treatment of COVID-19.

7 Jun 2021

Beckman Coulter launches new Access AMH Advanced assay to predict poor ovarian response

Beckman Coulter, a global leader in diagnostics and infertility testing, announced today the launch of the first and only test that uses a validated cut-off to aid in the assessment of ovarian response.

7 Jun 2021

Mason researchers examine the potential anti-coronavirus activities of an over-the-counter drink

Could an over-the-counter health "shot" help fight COVID-19? George Mason University researchers think it just might.

5 Jun 2021

SARS-CoV-2 evades neutralizing antibodies and rapidly spreads by cell fusion, finds study

In a new study by researchers in the UK, Germany and South Africa, this process is visualized using time-lapse microscopy of a human cell lung line, demonstrating that SARS-CoV-2 can induce cell-to-cell fusion within 6 hours post-infection. Further, the application of neutralizing monoclonal antibodies or convalescent plasma was unable to prevent the spread of the virus by this mechanism, suggesting that removing SARS-CoV-2 from cells permissive of cell membrane fusion could be more difficult than other types of cell.

4 Jun 2021

Plant-based oil blend shows virucidal activity against SARS-CoV-2 and influenza viruses in vitro

A new preprint research paper posted to the bioRxiv* server offers a potential candidate for disinfecting the respiratory tract and mouth during and after exposure to the virus, in the form of proprietary herbal oil named Viruxal.

3 Jun 2021

How can nanomaterials help in the fight against COVID-19?

Researchers have reviewed different types of nanomaterials and how they can be used for the detection, prevention, and treatment of coronavirus disease 2019 (COVID-19).

3 Jun 2021

Optimized Tube Plate for Enzyme Studies

BioChromato Inc. has developed an enzyme assay product - the RAPID Tube Plate 600 (TP-600) that is helping deliver outstanding results in in vitro metabolic stability studies.

From BioChromato Inc. 3 Jun 2021

Newly developed spheroidal structure reproduces the microenvironment of tumors

Every tumor is different, every patient is different. So how do we know which treatment will work best for the patient and eradicate the cancer? In order to offer a personalised treatment that best suits the case being treated, a team of scientists led by the University of Geneva (UNIGE), Switzerland, had already developed a spheroidal reproduction of tumors that integrates the tumor cells, but also their microenvironment.

3 Jun 2021

Single mutation to bat virus spike protein allows cell entry using human ACE2

In a paper recently uploaded to the preprint server bioRxiv by Kirchhoff et al. (May 31st, 2021) it is demonstrated that a single mutation to the RaTG13 spike protein results in significantly greater affinity towards the human receptor, indicating that the presence of a positively charged amino group at this position better facilitates interaction with the human ACE2 receptor, and helping to identify other viruses with zoonotic potential.

3 Jun 2021

Epigenetic regulation affects the 3D structure of genome

All the cells of an organism share the same DNA sequence, but their functions, shapes or even lifespans vary greatly. This happens because each cell "reads" different chapters of the genome, thus producing alternative sets of proteins and embarking on different paths.

3 Jun 2021

in vitro News and Research

Cell-to-cell contact helps in spreading SARS-CoV-2, finds study

NIH researchers find that the SARS-CoV-2 Nsp15’s uridine cleavage can evade the immune response

Immunomodulatory therapies for nephrological autoimmune diseases may help treat severe COVID-19

NIH researchers identify novel small molecule inhibitors of SARS-CoV-2 variants

New chip mimicking bovine endometrium could play key role in cattle’s pregnancy success

Study offers a deeper understanding of the molecular basis for schizophrenia

Natural products show promise against COVID-19 via iron chelation

Redhill Biopharma announces completion of enrollment for oral opaganib phase 2/3 COVID-19 study

Genome-scale CRISPR screens pinpoint promising antiviral compounds against SARS-CoV-2

Researchers identify a bacterium with anti-SARS-CoV-2 activity in vitro: Dolosigranulum pigrum

The great promise of antiviral peptides against SARS-CoV-2

Beckman Coulter launches new Access AMH Advanced assay to predict poor ovarian response

Mason researchers examine the potential anti-coronavirus activities of an over-the-counter drink

SARS-CoV-2 evades neutralizing antibodies and rapidly spreads by cell fusion, finds study

Plant-based oil blend shows virucidal activity against SARS-CoV-2 and influenza viruses in vitro

How can nanomaterials help in the fight against COVID-19?

Optimized Tube Plate for Enzyme Studies

Newly developed spheroidal structure reproduces the microenvironment of tumors

Single mutation to bat virus spike protein allows cell entry using human ACE2

Epigenetic regulation affects the 3D structure of genome

Human iPSCs: A Full Guide to Advanced in Vitro Models and Applications eBook

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

Expanding access to NMR with the Fourier 80 Duo

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