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Single gene therapy for lipoprotein lipase deficiency reduces severity and frequency of pancreatitis

Over a 6-year period, patients with the genetic disease lipoprotein lipase deficiency (LPLD) who received a single gene therapy treatment of alipogene tiparvovec had a marked reduction in the severity and frequency of pancreatitis.

8 Nov 2016

Mild to moderate rise in blood fats increases risk of developing acute pancreatitis

New research from the University of Copenhagen shows that mild to moderate levels of blood fats equals an increased risk developing acute pancreatitis. It is far more serious than we previously believed it to be, according to the professor behind the study.

8 Nov 2016

Scientists use latest sequencing technology to review genetic makeup of ataxias syndrome

According to a recent study published in JAMA Neurology, Northwestern Medicine scientists have examined more than a century of data of the genetic makeup of ataxias, a neurodegenerative disorder, to better understand the different forms of this devastating disease and how it affects patients.

8 Nov 2016

Researchers discover signaling pathway that can stop brain tumor formation in animal models

A research team at the Krembil Research Institute has discovered that a signaling pathway which controls blood vessel development in the brain has the ability to stop brain tumor formation in animal models of medulloblastoma, the most common malignant brain tumor diagnosed in children.

8 Nov 2016

Scientists investigate role of mitochondria in Alzheimer's disease pathology

On Nov. 25, 1901, a 51-year-old woman is admitted to a hospital in Frankfurt, Germany, displaying a bizarre constellation of symptoms.

8 Nov 2016

Researchers uncover possible targeted therapy for new, high-risk subtype of ALL

An international research team led by St. Jude Children's Research Hospital investigators has uncovered details of a new, high-risk subtype of acute lymphoblastic leukemia (ALL) as well as a possible targeted therapy.

8 Nov 2016

Targeted precision medicine can eliminate cancer risk in patients with Type 2 diabetes

The links between Type 2 diabetes and cancer are complex: people suffering from diabetes mellitus essentially have a higher risk of developing cancer but, on top of that, some diabetes drugs are also suspected of increasing the risk in some cases.

8 Nov 2016

Study finds lack of improvement in health status of childhood cancer survivors

Long-term survivors of childhood cancer live longer thanks to improvements to cancer treatments, but a new study looking at three decades of therapy suggests patients do not report better health status.

8 Nov 2016

Researchers shed light on how success of gut microbiome treatments may depend on genetics

Our gut microbiomes--the bacteria that live in our digestive tract--play major roles in our health. Scientists around the world are studying therapies that manipulate the microbiome, including probiotics (such as live bacterial cultures in yogurt), prebiotics (edible fibers meant to promote beneficial bacteria), antibiotics and transplants of microbes from healthy people.

7 Nov 2016

Nearly 20% of children with celiac disease have persistent enteropathy despite gluten-free diet

Even after a year on a gluten-free diet, nearly 20 percent of children with celiac disease continue to have intestinal abnormalities (enteropathy) on repeat biopsies, reports a study in the Journal of Pediatric Gastroenterology and Nutrition, official journal of the European Society for Paediatric Gastroenterology, Hepatology and Nutrition and the North American Society for Pediatric Gastroenterology, Hepatology and Nutrition. The journal is published by Wolters Kluwer.

7 Nov 2016

Machine learning accurately identifies suicidal behavior using person's spoken or written words

Using a person's spoken or written words, new computer tools can identify with great accuracy whether that person is suicidal, mentally ill but not suicidal, or neither.

7 Nov 2016

Researchers develop new blood test that can accurately diagnose concussions

Scientists from Children's Health Research Institute, a program of Lawson Health Research Institute, and Western University have developed a new blood test that identifies with greater than 90 per cent certainty whether or not an adolescent athlete has suffered a concussion.

7 Nov 2016

Biologic drugs may help prevent progressive bone loss in patients with RA

A new review by the International Osteoporosis Foundation Chronic Inflammation and Bone Structure Working Group concludes that early and aggressive treatment of Rheumatoid Arthritis (RA) with biologic drugs, specifically biological disease-modifying anti-rheumatic drugs (DMARDs), may be most effective in halting progressive bone loss in patients with RA.

7 Nov 2016

Characteristics of brain tumour provide insight into survival, treatment options for patients over 70

Characteristics like seizures, location of the tumour, and pressure in the brain, give insight into length of survival and treatment options for brain tumour patients over the age of 70, according to new research presented at the National Cancer Research Institute's Cancer Conference in Liverpool.

7 Nov 2016

Group of circulating tumour cells in the blood linked to prostate cancer spread

Researchers have found a group of circulating tumour cells in prostate cancer patient blood samples which are linked to the spread of the disease, according to new research presented at the National Cancer Research Institute Cancer Conference in Liverpool.

7 Nov 2016

Suppressing bone specific protein can alleviate radiotherapy-induced osteoporosis

Radiotherapy destroys cancer cells using high-energy ionizing radiation to damage DNA and induce cell death. About two million patients per year in the United States - more than 50 percent of all cancer patients -- receive radiotherapy at some stage during their illness, either alone or in combination with chemotherapy, surgery, and targeted medicines.

7 Nov 2016

New treatment may reduce side effects linked to transfusions of red blood cells

A new treatment may diminish a dangerous side effect associated with transfusions of red blood cells (RBCs) known as pulmonary hypertension, an elevated blood pressure in the lungs and heart that can lead to heart failure, suggests a new study published in the November issue of Anesthesiology, the peer-reviewed medical journal of the American Society of Anesthesiologists.

7 Nov 2016

Vitamin D deficiency may increase risk of developing bladder cancer

Vitamin D deficiency is associated with an increased risk of developing bladder cancer, according to a systematic review of seven studies presented today at the Society for Endocrinology annual conference in Brighton.

7 Nov 2016

High-altitude dwellers prone to chronic mountain sickness produce huge amounts of red blood cells

To better understand why some people adapt well to life at high altitude while others don't, researchers at University of California San Diego School of Medicine studied red blood cells derived from representatives of both groups living in the Andes Mountains.

7 Nov 2016

Gas-filled balloon capsules provide new low risk treatment option for patients with obesity

Patients with obesity who swallowed gas-filled balloon capsules designed to help them eat less, lost 1.9 times more weight than patients who relied on diet, exercise and lifestyle therapy alone, according to new research presented today at ObesityWeek 2016, the largest international event focused on the basic science, clinical application and prevention and treatment of obesity.

7 Nov 2016

Hospital News and Research

Single gene therapy for lipoprotein lipase deficiency reduces severity and frequency of pancreatitis

Mild to moderate rise in blood fats increases risk of developing acute pancreatitis

Scientists use latest sequencing technology to review genetic makeup of ataxias syndrome

Researchers discover signaling pathway that can stop brain tumor formation in animal models

Scientists investigate role of mitochondria in Alzheimer's disease pathology

Researchers uncover possible targeted therapy for new, high-risk subtype of ALL

Targeted precision medicine can eliminate cancer risk in patients with Type 2 diabetes

Study finds lack of improvement in health status of childhood cancer survivors

Researchers shed light on how success of gut microbiome treatments may depend on genetics

Nearly 20% of children with celiac disease have persistent enteropathy despite gluten-free diet

Machine learning accurately identifies suicidal behavior using person's spoken or written words

Researchers develop new blood test that can accurately diagnose concussions

Biologic drugs may help prevent progressive bone loss in patients with RA

Characteristics of brain tumour provide insight into survival, treatment options for patients over 70

Group of circulating tumour cells in the blood linked to prostate cancer spread

Suppressing bone specific protein can alleviate radiotherapy-induced osteoporosis

New treatment may reduce side effects linked to transfusions of red blood cells

Vitamin D deficiency may increase risk of developing bladder cancer

High-altitude dwellers prone to chronic mountain sickness produce huge amounts of red blood cells

Gas-filled balloon capsules provide new low risk treatment option for patients with obesity

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