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Anti-inflammatory drug shown to promote cardiac reprogramming

Once damaged, the human heart does a poor job of repairing itself, so this is a key priority for treating heart failure. One way of restoring cardiac function is to reprogram non-cardiac body cells such as fibroblasts into heart muscle cells (cardiomyocytes) using a collection of cardiac transcription factors.

6 Mar 2019

New mathematical method to map cell regulatory networks

Faster results. Lower costs. Fewer cells. A new mathematical method developed by researchers at Cincinnati Children's and New York University may soon make it much easier to conduct more of the complex data analysis needed to drive advances in the exploding field of personalized medicine.

6 Mar 2019

New tool uncovers molecular causes of different diseases

Princeton University researchers are gaining new insights into the causes and characteristics of diseases by harnessing machine learning to analyze molecular patterns across hundreds of diseases simultaneously.

1 Mar 2019

Research identifies super-enhancers as novel target for pancreatic ductal adenocarcinoma

Differential H3K27AC marks were identified at enhancer regions of genes including c-MYC, MED1, OCT-4, NANOG, and SOX2 that can act as super-enhancers (SE), cluster of genes in non-cancerous, cancerous and metastatic PDAC cell lines.

1 Mar 2019

Researchers analyze differing antioxidant levels in tomatoes of different colors

Naturally occurring antioxidants have been of great interest in recent years due to their recognizable health benefits. A study out of Universidad Autónoma Metropolitana in Mexico has clarified differing antioxidant levels by focusing on eight tomato genotypes with different-color fruit.

28 Feb 2019

Novel mechanism behind DNA damage control uncovered

DNA damage is occurring in our cells all the time due to external agents, such as exposure to sun, or internal agents, like reactive oxygen species.

26 Feb 2019

Scientists discover puzzle piece that plays key role in development of epilepsies

When an epileptic seizure occurs in the brain, the nerve cells lose their usual pattern and fire in a very fast rhythm. The cause is a complex interplay of various factors.

25 Feb 2019

New research finds how cancer cells acquire resistance to molecular-targeted drugs

Although molecular-targeted drugs have been known to show high efficacy to lung cancer patients, they also have limitations due to acquiring resistance to the drug used.

25 Feb 2019

Researchers discover new and rare skeletal disease

Researchers at Karolinska Institutet in Sweden have discovered a new and rare skeletal disease. In a study published in the journal Nature Medicine they describe the molecular mechanism of the disease, in which small RNA molecules play a role that has never before been observed in a congenital human disease.

25 Feb 2019

Neuron-derived estrogen key to making memories

Estrogen in the brain is important to keep neurons communicating and memories being made, scientists report.

25 Feb 2019

Clinical study shows tolerability and safety of investigational drug in boys with DMD

Patients with Duchenne muscular dystrophy have few treatment options. Medications currently available or in development either target only a subset of DMD patients with a particular genetic mutation or cause significant side effects.

23 Feb 2019

Mechanism behind how diabetes causes muscle loss revealed

Diabetes mellitus is associated with various health problems including decline in skeletal muscle mass. A research group led by Professor Wataru Ogawa at the Kobe University Graduate School of Medicine revealed that elevation of blood sugar levels leads to muscle atrophy and that two proteins, WWP1 and KLF15, play key roles in this phenomenon.

23 Feb 2019

Akna protein plays a key role in the regulation of neural stem cells

The use of stem cells to repair organs is one of the foremost goals of modern regenerative medicine.

22 Feb 2019

Study: Cancer stem-like cells are maintained by MTHFD2 mitochondrial metabolic enzyme

An increase in the incidence and mortality rate of cancer has been noted worldwide, especially for lung cancer.

22 Feb 2019

Phase 1 data reinforce safety profile of new drug for treating Duchenne muscular dystrophy

Patients with Duchenne muscular dystrophy (DMD) have few treatment options. Medications currently available or in development either target only a subset of DMD patients with a particular genetic mutation or cause significant side effects.

21 Feb 2019

Scientists uncover new mechanisms regulating neural stem cells

The use of stem cells to repair organs is one of the foremost goals of modern regenerative medicine. Scientists at Helmholtz Zentrum München and Ludwig Maximilian University of Munich have discovered that the protein Akna plays a key role in this process.

21 Feb 2019

Study quantifies hepatic and intestinal mRNA expression of Ugt isoforms in rats

In pharmaceutical companies, rats are used commonly in nonclinical studies to investigate the safety, efficacy, and pharmacokinetic profiles of drug candidates before they are entered into clinical studies. Most compounds administered via the oral route are metabolized in the liver and intestine, so the metabolism is a key determinant of pharmacokinetics.

20 Feb 2019

Mogrify to accelerate novel IP and cell therapies using $3.7m USD funding

Mogrify today announced a second close on its seed funding, bringing the total raised to $3.7 million USD, and the appointment of Darrin Disley as CEO.

20 Feb 2019

Bio-Rad launches new digital PCR system and kit for monitoring treatment response in CML patients

Bio-Rad Laboratories, Inc., a global leader of life science research and clinical diagnostic products, today announced that its QXDx AutoDG ddPCR System, which uses Bio-Rad's Droplet Digital PCR technology, and the QXDx BCR-ABL %IS Kit are the industry's first digital PCR products to receive U.S. Food and Drug Administration clearance.

15 Feb 2019

Genetic variations in a fourth gene associated with higher ALL risk in Hispanic children

St. Jude Children's Research Hospital scientists have identified genetic variations in a fourth gene that are associated with an increased risk of acute lymphoblastic leukemia in Hispanic children. The research appears today in the journal Blood.

15 Feb 2019

Transcription News and Research

Anti-inflammatory drug shown to promote cardiac reprogramming

New mathematical method to map cell regulatory networks

New tool uncovers molecular causes of different diseases

Research identifies super-enhancers as novel target for pancreatic ductal adenocarcinoma

Researchers analyze differing antioxidant levels in tomatoes of different colors

Novel mechanism behind DNA damage control uncovered

Scientists discover puzzle piece that plays key role in development of epilepsies

New research finds how cancer cells acquire resistance to molecular-targeted drugs

Researchers discover new and rare skeletal disease

Neuron-derived estrogen key to making memories

Clinical study shows tolerability and safety of investigational drug in boys with DMD

Mechanism behind how diabetes causes muscle loss revealed

Akna protein plays a key role in the regulation of neural stem cells

Study: Cancer stem-like cells are maintained by MTHFD2 mitochondrial metabolic enzyme

Phase 1 data reinforce safety profile of new drug for treating Duchenne muscular dystrophy

Scientists uncover new mechanisms regulating neural stem cells

Study quantifies hepatic and intestinal mRNA expression of Ugt isoforms in rats

Mogrify to accelerate novel IP and cell therapies using $3.7m USD funding

Bio-Rad launches new digital PCR system and kit for monitoring treatment response in CML patients

Genetic variations in a fourth gene associated with higher ALL risk in Hispanic children

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

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