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Mechanisms that govern HIV latency differ in the gut and blood, finds study

Mechanisms that govern HIV transcription and latency differ in the gut and blood, according to a study published November 15 in the open-access journal PLOS Pathogens by Steven Yukl of San Francisco Veterans Affairs Medical Center and the University of California, San Francisco, and colleagues.

16 Nov 2018

Artificial intelligence could be valuable tool to help young victims disclose traumatic testimony

When children are victims of crimes, the legal testimony they provide is known as forensic interviews. However, since victims are often traumatized and potentially abused by their caregivers they can be reluctant to come forward with accusations or disclose relevant information.

16 Nov 2018

Non-coding genetic variant plays key role in endothelial function and disease incidence

Atherosclerotic disease, the slow and silent hardening and narrowing of the arteries, is a leading cause of mortality worldwide. It is responsible for more than 15 million deaths each year, including an estimated 610,000 people in the United States.

15 Nov 2018

Study shows new emerging role of osteopontin in HCV-related hepatocellular carcinoma

Hepatitis C virus (HCV) infection is the major cause of hepatocellular carcinoma (HCC) and was estimated to be responsible for 745,000 deaths in 2012.

13 Nov 2018

GW study examines impact of nervous system on non-alcoholic fatty liver disease

Non-alcoholic fatty liver disease, the accumulation of fat in the liver of people who drink little or no alcohol, affects 1 in 3 Americans. NAFLD is a significant risk factor for Type 2 diabetes, insulin resistance, and hepatic carcinoma, and incidence of the disease is increasing with the growing obesity epidemic in the United States.

8 Nov 2018

Circadian clock could play key role in the fight against liver cancer

The body's internal clock could play a critical role in the fight against certain types of liver cancer, according to a preclinical study by scientists from The University of Texas Health Science Center at Houston (UTHealth). The results were published recently in the journal Nature Communications.

8 Nov 2018

CWRH/UH researcher receives grant to study role of KLF2 factor in vascular-related disorders

Transcription factors are proteins that determine whether specific genes are transcribed or not by binding to DNA. In other words, they help turn genes "on" or "off."

8 Nov 2018

Scientists discover new details about UHRF1 protein

Epigenetic changes often play an important role in cancer, because they cause the genetic material to be read incorrectly at certain locations. Genes that are especially critical are those that control the growth and death of cells.

7 Nov 2018

Researchers identify pathway to resolve allergic asthma

A group of Brazilian researchers succeeded in preventing allergic asthma from progressing in experimental models by increasing the amount of a protein. This increase, in turn, blocked the CD4+ T lymphocytes responsible for producing a cytokine that triggers a cascade of events resulting in the onset and progression of the disease.

6 Nov 2018

New findings highlight importance of inflammatory component in atherosclerosis pathogenesis

One of the main characteristics of atherosclerosis is the accumulation of lipids in the intimal layer of the arterial wall.

29 Oct 2018

New method increases virus production in cells to generate more vectors for gene transfer

Researchers at Tokyo Medical and Dental University have established a method to increase the released lentiviral particles produced by host cells, which will aid the use of the vectors for introducing foreign genes into cells

29 Oct 2018

Skin cells show minimal damage, maximum pigmentation when exposed to sunlight every 48 hours

Skin cells show the least amount of DNA damage and produce the most amount of melanin when exposed to sunlight in 48 hour windows, according to new study.

25 Oct 2018

Scientists determine normal function of gene associated with ALS and FTD

The normal function of a gene associated with the neurodegenerative diseases amyotrophic lateral sclerosis and frontotemporal dementia has been determined for the first time by University of Bath scientists.

24 Oct 2018

Researchers reach new milestone in understanding muscle formation

Researchers from the Randall Centre for Cell & Molecular Biophysics believe they have reached a new milestone in the understanding of muscle formation that could help define new cellular and molecular approaches in pathological conditions affecting muscle wellness.

24 Oct 2018

New type of molecule shows early promise against treatment-resistant prostate cancer

A new type of molecule blocks the action of genes that drive the growth of therapy-resistant prostate cancer, a new study finds.

23 Oct 2018

Dysfunction of single gene leads to miscarriages

A single gene of the mother plays such a crucial role in the development of the placenta that its dysfunction leads to miscarriages.

19 Oct 2018

Newly discovered compound shows potential for treating Parkinson's disease

A joint research group centered around Professor Hideyuki Okano and Associate Professor Jun Kohyama, Department of Physiology of the Keio University School of Medicine, together with a research group of Eisai Co., Ltd. has identified a compound that has the potential to be a treatment for Parkinson's disease by using dopaminergic neurons differentiated from induced pluripotent stem (iPS) cells from patients with familial Parkinson's disease.

19 Oct 2018

Targeting immune checkpoints in microglia could reduce out-of-control neuroinflammation

A group of Massachusetts General Hospital investigators is proposing that targeting immune checkpoints - molecules that regulate the activity of the immune system - in immune cells called microglia could reduce the inflammatory aspects of important neurodegenerative diseases like Alzheimer's disease, Parkinson's disease and amyotrophic lateral sclerosis.

17 Oct 2018

Scientists shed light on roles of transcription factors, TP63 and SOX2, in squamous cell carcinoma

Squamous cell carcinomas are aggressive malignancies arising from squamous epithelium of various organs, such as esophagus, head and neck, lung and skin. Previous studies demonstrated that two master transcription factors, TP63 and SOX2, effect genomic activation in SCCs.

15 Oct 2018

Study unravels how cancer stem cells use normal genes in abnormal ways

CDK1 is a "normal" protein - its presence drives cells through the cycle of replication. And MHC Class I molecules are "normal" as well - they present bits of proteins on the surfaces of cells for examination by the immune system.

15 Oct 2018

Transcription News and Research

Mechanisms that govern HIV latency differ in the gut and blood, finds study

Artificial intelligence could be valuable tool to help young victims disclose traumatic testimony

Non-coding genetic variant plays key role in endothelial function and disease incidence

Study shows new emerging role of osteopontin in HCV-related hepatocellular carcinoma

GW study examines impact of nervous system on non-alcoholic fatty liver disease

Circadian clock could play key role in the fight against liver cancer

CWRH/UH researcher receives grant to study role of KLF2 factor in vascular-related disorders

Scientists discover new details about UHRF1 protein

Researchers identify pathway to resolve allergic asthma

New findings highlight importance of inflammatory component in atherosclerosis pathogenesis

New method increases virus production in cells to generate more vectors for gene transfer

Skin cells show minimal damage, maximum pigmentation when exposed to sunlight every 48 hours

Scientists determine normal function of gene associated with ALS and FTD

Researchers reach new milestone in understanding muscle formation

New type of molecule shows early promise against treatment-resistant prostate cancer

Dysfunction of single gene leads to miscarriages

Newly discovered compound shows potential for treating Parkinson's disease

Targeting immune checkpoints in microglia could reduce out-of-control neuroinflammation

Scientists shed light on roles of transcription factors, TP63 and SOX2, in squamous cell carcinoma

Study unravels how cancer stem cells use normal genes in abnormal ways

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

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