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Novel compound shows promise as potential treatment for acute myeloid leukemia

A novel compound has shown promise in preclinical studies as a treatment for acute myeloid leukemia, more than doubling median days of survival even in a drug-resistant form of the disease.

21 Mar 2016

Trimeprazine improves β cell function, slows progression of diabetes

β cells in pancreatic islets are responsible for producing insulin, which is essential to regulate blood glucose homeostasis. In type 1 diabetes, pancreatic β cells are destroyed due to an autoimmune attack, whereas in type 2 diabetes, pancreatic β cells may have deficiencies in secreting insulin or insulin-responding tissues can become insulin resistant.

21 Mar 2016

Researchers reveal link between necrotizing enterocolitis and uropathogenic E. coli

Necrotizing enterocolitis is an intestinal disease that afflicts about one in 10 extremely premature infants and is fatal in nearly one-third of cases. The premature infant gut is believed to react to colonizing bacteria, causing damage to the intestinal walls and severe infection.

21 Mar 2016

Penn study calls on physicians to avoid over-prescribing opioids for surgical patients

Physicians are prescribing more opioid painkillers than ever before to patients undergoing common surgeries, according to new research from the department of Anesthesiology and Critical Care at the Perelman School of Medicine at the University of Pennsylvania.

21 Mar 2016

Simple TB screening and isoniazid can be effective for HIV patients at risk for TB

The number one killer of HIV patients in resource-limited areas, including parts of Africa and India, is tuberculosis (TB), underscoring the need for optimal treatments and effective strategies to address this deadly co-infection. But TB is harder to detect in HIV-infected patients and diagnostic test results take time, so many healthcare providers prescribe multi-drug TB treatments as a precaution.

20 Mar 2016

Innovative treatment may help prevent brain swelling, death in stroke patients

New research has provided more evidence that an innovative treatment strategy may help prevent brain swelling and death in stroke patients. J. Marc Simard, professor of neurosurgery at the University of Maryland School of Medicine, along with colleagues at Yale University and Massachusetts General Hospital, found that Cirara, an investigational drug, powerfully reduced brain swelling and death in patients who had suffered a type of large stroke called malignant infarction, which normally carries a high mortality rate.

19 Mar 2016

Antibiotic treatment for mild appendicitis does not increase risk for complications

Using antibiotics as the primary treatment for mild appendicitis does not increase the risk for complications at least in the first year. But other considerations must also be taken into account, say researchers.

19 Mar 2016

Manipulation of NAD could lead to potential therapy for acute kidney injury

Approximately one out of five hospitalized adults and one out of three hospitalized children worldwide experience acute kidney injury, the sudden loss of kidney function. Many different factors, including surgery, chemotherapy or shock, can lead to acute kidney injury, but exactly why the kidneys are so vulnerable to these and other stressors has not been well understood.

19 Mar 2016

Study links severe early childhood caries to microbiome among Canadian First Nations children

Today at the 45th Annual Meeting & Exhibition of the American Association for Dental Research, researcher Robert Schroth, University of Manitoba, Children's Hospital Research Institute of Manitoba, Winnipeg, Canada, will present a study titled "Microbiome Associated With Severe Caries in Canadian First Nations Children." The AADR Annual Meeting is being held in conjunction with the 40th Annual Meeting of the Canadian Association for Dental Research.

19 Mar 2016

Neutralizing acidic tumor environment increases efficacy of immune-targeting cancer therapies

Cancer cells have the ability to grow in an acidic tumor environment that is detrimental to other cells, including immune cells. In a Cancer Research cover article published this week, Moffitt Cancer Center reported that neutralizing the acidic tumor environment increases the efficacy of several immune-targeting cancer therapies.

19 Mar 2016

Transcranial direct current stimulation assists chronic stroke rehabilitation

Adding ipsilesional anodal transcranial direct current stimulation to upper limb rehabilitation delivers motor improvements in chronic stroke patients that last for at least 3 months, a randomised trial shows.

18 Mar 2016

Stem cell therapy restores normal bone structure in mice with age-related osteoporosis

Imagine telling a patient suffering from age-related (type-II) osteoporosis that a single injection of stem cells could restore their normal bone structure. This week, with a publication in STEM CELLS Translational Medicine, a group of researchers from the University of Toronto and The Ottawa Hospital suggest that this scenario may not be too far away.

18 Mar 2016

Family-linked treatment may benefit children with cardiomyopathy-related chronic heart disease

A newly published national study by the Children's Hospital of Michigan and Wayne State University School of Medicine researchers shows that "parental impact and family functioning" become increasingly abnormal when children with cardiomyopathy-related chronic heart disease are more severely ill than children less affected by the disease.

18 Mar 2016

Study: Conservative care could be a reasonable choice for selected kidney failure patients

A new study found no significant survival advantage among elderly kidney failure patients who chose dialysis over conservative management. The findings, which appear in an upcoming issue of the Clinical Journal of the American Society of Nephrology, indicate that conservative care may be a reasonable choice for selected older patients.

18 Mar 2016

Genomic profiling could help provide targeted therapies for difficult to treat cancer tumors

Research from Rutgers Cancer Institute of New Jersey examining difficult to treat cancer tumors through genomic profiling shows that tumors with alterations in a signaling pathway responsible for cell regulation may respond to targeted therapy regardless of where the tumor originated in the body.

18 Mar 2016

Harvard University launches iPhone research app to examine health and well-being football players

The Football Players Health Study at Harvard University--a series of studies that examine the health and well-being of former football players and aims to develop more effective diagnostic and therapeutic interventions--today launched TeamStudy, an iPhone research app built using ResearchKit, the open source software framework designed by Apple.

18 Mar 2016

Treatment guidelines need to be changed for rare, genetic form of diabetes, study suggests

Patients with a rare, genetic form of diabetes often are misdiagnosed as having type 2 diabetes because the two share symptoms.

18 Mar 2016

MEDICREA announces use of UNiD Lab Services in more than 500 surgeries worldwide

MEDICREA, the leading medical device company for developing patient-specific solutions for the treatment of spinal conditions) has announced the groundbreaking UNiD Lab Services have been used in more than 500 surgeries worldwide.

18 Mar 2016

Older types of arthritis medicine appear to be dangerous for the heart

Many Danes are prescribed NSAIDs for the treatment of painful conditions, fever and inflammation. But the treatment also comes with side effects, including the risk of ulcers and increased blood pressure.

17 Mar 2016

Study: Prenatal exposure to PAH leads to mental health problems in children

Exposure to common air pollutants during pregnancy may predispose children to problems regulating their thoughts, emotions, and behaviors later on, according to a new study led by researchers at the Columbia Center for Children's Environmental Health within Columbia University's Mailman School of Public Health and New York State Psychiatric Institute.

17 Mar 2016

Hospital News and Research

Novel compound shows promise as potential treatment for acute myeloid leukemia

Trimeprazine improves β cell function, slows progression of diabetes

Researchers reveal link between necrotizing enterocolitis and uropathogenic E. coli

Penn study calls on physicians to avoid over-prescribing opioids for surgical patients

Simple TB screening and isoniazid can be effective for HIV patients at risk for TB

Innovative treatment may help prevent brain swelling, death in stroke patients

Antibiotic treatment for mild appendicitis does not increase risk for complications

Manipulation of NAD could lead to potential therapy for acute kidney injury

Study links severe early childhood caries to microbiome among Canadian First Nations children

Neutralizing acidic tumor environment increases efficacy of immune-targeting cancer therapies

Transcranial direct current stimulation assists chronic stroke rehabilitation

Stem cell therapy restores normal bone structure in mice with age-related osteoporosis

Family-linked treatment may benefit children with cardiomyopathy-related chronic heart disease

Study: Conservative care could be a reasonable choice for selected kidney failure patients

Genomic profiling could help provide targeted therapies for difficult to treat cancer tumors

Harvard University launches iPhone research app to examine health and well-being football players

Treatment guidelines need to be changed for rare, genetic form of diabetes, study suggests

MEDICREA announces use of UNiD Lab Services in more than 500 surgeries worldwide

Older types of arthritis medicine appear to be dangerous for the heart

Study: Prenatal exposure to PAH leads to mental health problems in children

Improving healthcare sustainability through carbon data

Managing vibration in IVF laboratories

A New Approach to Preventing Bladder Cancer Recurrence

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