Growth Factor News and Research

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Increlex - first major innovation in 20 years for the treatment of growth failure

Rush University Medical Center is participating in a clinical trial to evaluate the potential benefit of the first major innovation in 20 years for the treatment of growth failure.

26 Sep 2005

Tumor formation is generated by a complex interaction of both mechanical as well as chemical signals

The relationship between tissue rigidity and tumor formation is fairly well established; however, what is not so well understood is what happens on a molecular level that contributes to such stiffness.

26 Sep 2005

Mutations in receptor tyrosine kinases provide potential for highly-targeted cancer therapies

Scientists from J. Craig Venter Institute, Ludwig Institute for Cancer Research, and The Johns Hopkins University School of Medicine identified three novel mutations in two receptor tyrosine kinases in glioblastoma tumors using high throughput sequencing.

26 Sep 2005

Link between tissue tension and tumor formation

Most investigations into cancer have focused on chemical signals, but a new research study provides rare insight into how mechanical force can regulate cellular behavior.

20 Sep 2005

Simple new way to modify collagen, paving the way for better infection-fighting bandages

Collagen often pops up in beauty products and supermodel lips. But by mating collagen with a molecular hitchhiker, materials scientists at Johns Hopkins hope to create some important medical advances.

30 Aug 2005

Nitric oxide synthase plays a role in peripheral vascular disease

The enzyme nitric oxide synthase plays a role in peripheral vascular disease, a common disease that impairs the mobility of 25 percent of people over the age of 50, according to a Yale study in the Proceedings of the National Academy of Sciences (PNAS).

26 Aug 2005

Discovery of signaling component that influences spread of breast cancer cells

Researchers at the Virginia Commonwealth University Massey Cancer Center have found a new signaling component that influences movement of human breast cancer cells toward epidermal growth factor.

22 Aug 2005

Mutations in the targets of designer drugs critically influence their effectiveness

Two designer cancer drugs differed dramatically in a laboratory test comparing their ability to shut down a mutant, overactive growth signal in lung cancer cells, reports a team headed by scientists at the Dana-Farber Cancer Institute.

18 Aug 2005

Method to propagate mouse brain stem cells derived from ES cells

It's hard to grow stem cells in a dish. In particular, while it is possible to multiply mouse embryonic stem cells in culture, propagating stem cells that are specific to distinct tissues (e.g. neural stem cells) has proven to be a challenge.

16 Aug 2005

Researchers identify protein called EMP-1 that is present in the tumors of patients who fail to respond to treatment with gefitinib

By the time the human genome was mapped, cancer researchers had already begun investigating the proteins that were encoded by these newly identified genes.

9 Aug 2005

Arf gene prevents excessive growth of blood vessels in the developing eye

A gene better known for its role in preventing cancer also plays a key role in the developing embryo, where the gene prevents excessive growth of blood vessels, according to investigators at St. Jude Children's Research Hospital.

2 Aug 2005

Scientists have identified the first genetic mutations that cause the aorta to widen, tear and rupture

Finding biological markers that flag aneurysm, a bulging of the aorta that leads to dissection, a lengthwise separation of tissues in the artery wall, is critically important for early diagnosis.

25 Jul 2005

Important find will help design appropriate screening and therapy for women carrying fetuses impaired in their growth

In her research, Dr. Andree Gruslin encountered many pregnant women who could not carry their fetuses to term because the placenta, and in turn the fetus, were too small. In once case, she followed a woman who had had eight consecutive miscarriages due to this condition. Thanks to this latest discovery, she now understands why.

19 Jul 2005

New and more efficient target for antiangiogenic therapy

Scientists now have a more complete understanding of how cancer cells send signals to surrounding tissues to promote development of the blood supply needed to support tumor growth.

19 Jul 2005

New discovery could help in the fight against cancer

University of Michigan researchers have figured out one more component in cancer cells' aggressive growth - and hope that knowledge can help kill the cells.

18 Jul 2005

New finding has potentially major implications for anti-angiogenic therapy

Scientists supported by the National Institute of Dental and Craniofacial Research (NIDCR) have added a key new piece to the puzzle of how tumor cells induce new blood vessels to form and fuel their abnormal growth, a well-known process called angiogenesis.

18 Jul 2005

Complicated plasminogen system yields potential therapeutic target; Implications for aging and degenerative diseases

Skeletal muscles naturally repair themselves very efficiently after injury. But when they don’t, otherwise successful recovery following damage from overuse during exercise, surgery or trauma can be stymied. Furthermore, as we age, muscle repair slows noticeably, and in Duchenne Muscular Dystrophy and other degenerative muscle diseases, normal repair functions can’t cope with disease progression.

14 Jul 2005

Erlotinib increases survival in patients with advanced non-small cell lung cancer

An international clinical study led by Canadian researchers has demonstrated that a drug called erlotinib increases survival in patients with advanced non-small cell lung cancer who typically have no other treatment options.

13 Jul 2005

Sirna Therapeutics granted new UK patents

Sirna Therapeutics has announced that the United Kingdom (UK) Patent Office has granted the Company two additional short interfering RNA (siRNA) target patents. The first patent covers any siRNA with one or more chemical modifications targeting Vascular Endothelial Growth Factor (VEGF).

12 Jul 2005

Urine testing may predict birthmarks

Vascular anomalies - birthmarks caused by abnormal development of arteries, capillaries, veins or lymph vessels - can sometimes begin to progress, requiring aggressive treatment to save the child's health or vision. Research at Children's Hospital Boston now suggests that urine testing can help monitor these anomalies and predict those about to become a serious threat.

6 Jul 2005

Growth Factor News and Research

Increlex - first major innovation in 20 years for the treatment of growth failure

Tumor formation is generated by a complex interaction of both mechanical as well as chemical signals

Mutations in receptor tyrosine kinases provide potential for highly-targeted cancer therapies

Link between tissue tension and tumor formation

Simple new way to modify collagen, paving the way for better infection-fighting bandages

Nitric oxide synthase plays a role in peripheral vascular disease

Discovery of signaling component that influences spread of breast cancer cells

Mutations in the targets of designer drugs critically influence their effectiveness

Method to propagate mouse brain stem cells derived from ES cells

Researchers identify protein called EMP-1 that is present in the tumors of patients who fail to respond to treatment with gefitinib

Arf gene prevents excessive growth of blood vessels in the developing eye

Scientists have identified the first genetic mutations that cause the aorta to widen, tear and rupture

Important find will help design appropriate screening and therapy for women carrying fetuses impaired in their growth

New and more efficient target for antiangiogenic therapy

New discovery could help in the fight against cancer

New finding has potentially major implications for anti-angiogenic therapy

Complicated plasminogen system yields potential therapeutic target; Implications for aging and degenerative diseases

Erlotinib increases survival in patients with advanced non-small cell lung cancer

Sirna Therapeutics granted new UK patents

Urine testing may predict birthmarks

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