Metastasis News and Research

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Metastasis is the spread of cancer from one part of the body to another. A tumor formed by cells that have spread is called a “metastatic tumor” or a “metastasis.” The metastatic tumor contains cells that are like those in the original (primary) tumor. The plural form of metastasis is metastases

Few well performed studies address management of lymph node positive prostate cancer

Dr. Gregory Swanson and associates from the University of Texas, San Antonio Health Science Center reviews the data for various treatment options in patients with lymph node positive prostate cancer (CaP).

27 Jun 2006

Gleevec strangles drug-resistant, metastatic prostate cancer

A medication used to treat other types of cancer strangles drug-resistant, metastatic prostate cancer by cutting off its blood supply, researchers from The University of Texas M. D. Anderson Cancer Center report in the June 7 issue of the Journal of the National Cancer Institute.

7 Jun 2006

Plasminogen activator inhibitor type 2 may play role in infection and dry eye

Plasminogen Activator Inhibitor Type 2 (PAI-2), a protein found in various cell types including the skin, has been discovered in the tissue covering the eye and may have future clinical implications in various pathologies of the ocular surface such as eye infection or dry eye.

17 May 2006

Chemotherapy regimen predicts steatohepatitis and an increase in 90-day mortality after surgery for hepatic colorectal metastases

Patients and their physicians should be careful when selecting a chemotherapy drug to treat colorectal cancer that has spread to the liver, say researchers at The University of Texas M. D. Anderson Cancer Center in Houston.

3 May 2006

Cause and treatment for aggressive head and neck cancer may have been found

Researchers report that they have found a potential molecular cause for the aggressive growth and spread of human head and neck squamous cell carcinoma, a highly malignant form of cancer with a very high death rate.

26 Apr 2006

Reversing cell division has implications for the treatment of cancer

A scientist in the United States has apparently found a way to reverse the process of cell division.

13 Apr 2006

Researchers suggest drug could block metastasis or reduce pain for bone cancer patients

An international research team has identified what may be a critical molecule in the ability of tumours to metastasize -- or spread -- into bone.

13 Apr 2006

Scientists identify a new gene that causes the spread of cancer

Professor Philip Rudland, Dr Guozheng Wang and Dr Roger Barraclough from Liverpool University's Cancer and Polio Research Fund Laboratories have discovered an additional member of the S100 family of protein genes - S100P - that causes the spread of cancerous cells from an original tumour to other parts of the body.

11 Apr 2006

A genomic signature of 254 genes predicting clinical outcome in Primary Cutaneous Melanoma identified

EORTC Melanoma Group researchers have identified a genomic signature predicting clinical outcome in Primary Cutaneous Melanoma, after patients having undergone standard treatment.

6 Apr 2006

New mechanism that initiates metastasis

Researchers have known for years that the enzyme MMP-9 plays a key role in the spread of colorectal cancer. Now, scientists at Jefferson Medical College in Philadelphia have found out how the enzyme helps initiate the process, known as metastasis.

4 Apr 2006

Johns Hopkins scientists identify genes in fruitflies that may shed light on human cancer spread

By searching through all the genes in the fruitfly genome, Johns Hopkins scientists have identified those required for a certain type of cell migration and simultaneously captured a global view of all the genes turned on when cells are on the move.

4 Apr 2006

Regular use of COX-2 inhibitors may reduce the risk of breast cancer

Results from a new, five-year study show that regular use of popular prescription pain relievers may reduce the risk of breast cancer by up to 71 percent and may offer similar benefit in the prevention of prostate, colon and lung cancers.

4 Apr 2006

Mayo Clinic discover cellular secret that may explain how certain cancers move and spread

If the mechanism that drives cancer movement - also called metastasis - can be understood well enough to manipulate it, new and better treatments can be developed for patients with metastatic cancers.

4 Apr 2006

Serum tumor markers predict extravesical disease in clinical stage T2 bladder cancer

Bladder cancer clinical staging is notoriously poor in patients with muscle invasive disease.

31 Mar 2006

Scientists identify a new gene that causes the spread of cancer

Professor Philip Rudland, Dr Guozheng Wang and Dr Roger Barraclough from the University’s Cancer and Polio Research Fund Laboratories have discovered an additional member of the S100 family of protein genes - S100P - that causes the spread of cancerous cells from an original tumour to other parts of the body.

30 Mar 2006

Trial of paclitaxel with or without bevacizumab as first-line therapy for locally recurrent or metastatic breast cancer

Results from a large, randomised clinical trial for patients with breast cancer show that those who received bevacizumab (Avastin.) in combination with paclitaxel (Taxol.) survived without the disease getting worse for almost twice as long as patients who received paclitaxel alone.

23 Mar 2006

Thrombocytosis: A clinical marker of tumor aggressiveness in renal cell carcinoma

Molecular and serum markers of prognosis in renal cell carcinoma have remained elusive. In large part, tumor (TNM) stage, Fuhrman grade, and patient performance status have stood the test of time as the most valuable factors in predicting patient outcome following surgery.

15 Mar 2006

Low PSA score after radiation can predict prostate cancer return

A consortium of prostate cancer experts have discovered, through a clinical investigation, that prostate cancer patients who have a lower prostate specific antigen (PSA) score after radiation therapy to treat their cancer are less likely to have their prostate cancer return or spread to other parts of their body than patients with a higher PSA score.

15 Mar 2006

Fibulins inhibit both tumor growth and blood-vessel formation

Researchers at National Jewish Medical and Research Center report in the March issue of Cancer Research that a pair of promising proteins, known as fibulins 3 and 5, slow the growth of cancer tumors in mice by preventing blood vessels from sprouting. The proteins are promising candidates for use in cancer therapy.

1 Mar 2006

Hepatic arterial infusion versus systemic therapy for hepatic metastases from colorectal cancer

A new study shows that patients whose colorectal cancer has spread to the liver who received an approach called hepatic arterial infusion (HAI) - the administration of chemotherapy directly to the liver through a pump in the abdomen - fare better than those who received traditional, intravenous chemotherapy.

1 Mar 2006

Metastasis News and Research

Further Reading

Few well performed studies address management of lymph node positive prostate cancer

Gleevec strangles drug-resistant, metastatic prostate cancer

Plasminogen activator inhibitor type 2 may play role in infection and dry eye

Chemotherapy regimen predicts steatohepatitis and an increase in 90-day mortality after surgery for hepatic colorectal metastases

Cause and treatment for aggressive head and neck cancer may have been found

Reversing cell division has implications for the treatment of cancer

Researchers suggest drug could block metastasis or reduce pain for bone cancer patients

Scientists identify a new gene that causes the spread of cancer

A genomic signature of 254 genes predicting clinical outcome in Primary Cutaneous Melanoma identified

New mechanism that initiates metastasis

Johns Hopkins scientists identify genes in fruitflies that may shed light on human cancer spread

Regular use of COX-2 inhibitors may reduce the risk of breast cancer

Mayo Clinic discover cellular secret that may explain how certain cancers move and spread

Serum tumor markers predict extravesical disease in clinical stage T2 bladder cancer

Scientists identify a new gene that causes the spread of cancer

Trial of paclitaxel with or without bevacizumab as first-line therapy for locally recurrent or metastatic breast cancer

Thrombocytosis: A clinical marker of tumor aggressiveness in renal cell carcinoma

Low PSA score after radiation can predict prostate cancer return

Fibulins inhibit both tumor growth and blood-vessel formation

Hepatic arterial infusion versus systemic therapy for hepatic metastases from colorectal cancer

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