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CNIO’s collaborative platform simplifies research on brain metastasis

Science is collaborative by nature, since scientific knowledge only advances, step by step, through combined efforts and findings. Nevertheless, there is often a lack of communication regarding the more technical and everyday advances in laboratory work, and as a result research progresses less quickly.

8 Jul 2020

New technology can rapidly disrupt existing biofilms that account for chronic diseases

Chronic and recurrent bacterial diseases are treatment-resistant due to the ability of the pathogens to establish biofilms, which act as fortresses built of extracellular DNA and proteins to protect populations of the bacteria.

8 Jul 2020

New standardized codes for healthcare systems released to track coronavirus

LOINC®, created and maintained by the Regenstrief Institute, is amplifying its global work to help track the coronavirus by releasing new standardized codes for healthcare systems' laboratory tests, clinical observations and other data.

7 Jul 2020

Researchers develop bioprinted skin model of cutaneous squamous cell carcinoma

The cover for issue 27 of Oncotarget features "Bimodal imaging examples of control and treated tumors (red) before and after the treatment period," by Browning, et al. and reported that the authors developed a 3-dimensional bioprinted skin model of cutaneous squamous cell carcinoma (cSCC) tumors together with a microscopy assay to test chemotherapeutic effects in tissue.

7 Jul 2020

Thermo Scientific MAS Omni Infectious Controls launched to assess the performance of serological assays

Thermo Fisher Scientific, the world leader in serving science, today announced the availability of the Thermo Scientific MAS Omni Infectious Disease quality control sets for monitoring serological assays for analytes such as HIV 1&2, Hepatitis B & C virus, Syphilis and HTLV I/II.

From Thermo Fisher Scientific Inc. 3 Jul 2020

New drug discovery shows promise in fighting acute respiratory illnesses

A collaboration between the University of Toronto's Faculty of Dentistry and the National Jewish Health in Denver -- the top-ranked respiratory research hospital in the U.S. -- has yielded a new drug discovery that could be useful to combat inflammation of all varieties and shows promise in fighting acute respiratory illnesses such as COVID-19.

2 Jul 2020

New platform prioritizes synergistic drug combinations against SARS-CoV-2

Researchers in the U.S. have used a new web-based platform to help identify synergistic and antagonistic drug combinations and their underlying mechanisms of action in the context of coronavirus disease 2019 (COVID-19).

2 Jul 2020

Ceftolozane/tazobactam combo broadens the range of antibiotic therapy, but shows no hint of added benefit

The combination of ceftolozane with tazobactam broadens the range of antibiotic therapy in adults with severe infections of the lungs, the urinary tract, the renal pelvis and the abdominal cavity.

2 Jul 2020

New technique reduces cell damage, improves IVF rates

Motile sperm are difficult to collect with a conventional cell sorter because they are vulnerable to physical damage.

2 Jul 2020

New technology can increase the quality of stem cells used in regenerative medicine

Stem cells have been holding great promise for regenerative medicine for years. In the last decade, several studies have shown that this type of cell, which in Spanish is called "mother cell" because of its ability to give rise to a variety of different cell types, can be applied in regenerative medicine for diseases such as muscular and nervous system disorders, among others.

2 Jul 2020

SARS-CoV-2 infection modeling in iPSC-derived type 2 cells

The most fatal form of COVID-19 disease is acute respiratory distress syndrome (ARDS), caused by direct viral injury as well as indirect noxious effects caused by cytotoxic chemicals and inflammatory processes. A new study published on the preprint server bioRxiv* in June 2020 shows that this is partly due to the rapid onset of inflammation caused by the infection of type 2 alveolar cells with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).

2 Jul 2020

Extended culture of human pancreatic slices as a model to study regeneration of beta cells

Scientists from the Diabetes Research Institute (DRI) at the University of Miami Miller School of Medicine have developed a method allowing for the long-term culture of "pancreatic slices" to study the regeneration of the human pancreas in real time.

1 Jul 2020

Common asthma drug may offer potential as treatment for Alzheimer's disease

A new study reveals that the common asthma drug salbutamol may offer potential as a treatment for Alzheimer's disease.

1 Jul 2020

Researchers develop biomedical device for use in regenerative medicine

The UPV/EHU-University of the Basque Country has developed a sustainable biomedical device from food industry by-products for use in regenerative medicine

1 Jul 2020

New polymeric heart valve could be a life-saver

Millions of persons around the world suffer from diseased and damaged heart valves. These patients require valve repair surgeries, and often when that is not possible, they need to take blood-thinners for life to prevent complications.

30 Jun 2020

Striking CryoEM image of SARS-CoV-2

A new study by researchers from the UK and Germany and published on the preprint server bioRxiv in June 2020 reports the results of a detailed study of the S protein on the intact virus, using cryoelectron microscopy (cryoEM) and tomography. This could help understand the conformation of the S protein on the virion and how it interacts with neutralizing antibodies.

30 Jun 2020

Research shows IQGAP1 as a common target in variants of triple negative breast cancer

The cover for issue 26 of Oncotarget features Figure 6, "Mislocalization of IQGAP1-BRCA1 in human TNBC tumors phenocopies the dominant mutants and the TNBC cells," by Osman, et al. and reported that IQGAP1 is a signaling scaffold implicated in TNBC, but its mechanism is unknown.

30 Jun 2020

Innovative technology permits faster, cheaper toxicological screening of drug candidates

Ramot at Tel Aviv University has signed a collaboration agreement with Bayer to develop and validate a platform for in vitro cardiotoxicity screening, using human heart tissues 3D-printed in Prof. Tal Dvir's Laboratory for Tissue Engineering and Regenerative Medicine at Tel Aviv University.

29 Jun 2020

3D structure of Aβ protein assemblies reveals a new mechanism of toxicity

The brains of millions of people suffering from Alzheimer´s disease (AD) are slowly and inescapably being depleted of neurons, which leads to the characteristic loss of memory and cognitive function associated with this condition.

29 Jun 2020

New polymeric heart valve is a promising alternative for valve replacement surgery, study shows

A new polymeric heart valve with a life span potentially longer than current artificial valves that would also prevent the need for the millions of patients with diseased heart valves to require life-long blood thinning tablets has been developed by scientists at the universities of Bristol and Cambridge.

29 Jun 2020

in vitro News and Research

CNIO’s collaborative platform simplifies research on brain metastasis

New technology can rapidly disrupt existing biofilms that account for chronic diseases

New standardized codes for healthcare systems released to track coronavirus

Researchers develop bioprinted skin model of cutaneous squamous cell carcinoma

Thermo Scientific MAS Omni Infectious Controls launched to assess the performance of serological assays

New drug discovery shows promise in fighting acute respiratory illnesses

New platform prioritizes synergistic drug combinations against SARS-CoV-2

Ceftolozane/tazobactam combo broadens the range of antibiotic therapy, but shows no hint of added benefit

New technique reduces cell damage, improves IVF rates

New technology can increase the quality of stem cells used in regenerative medicine

SARS-CoV-2 infection modeling in iPSC-derived type 2 cells

Extended culture of human pancreatic slices as a model to study regeneration of beta cells

Common asthma drug may offer potential as treatment for Alzheimer's disease

Researchers develop biomedical device for use in regenerative medicine

New polymeric heart valve could be a life-saver

Striking CryoEM image of SARS-CoV-2

Research shows IQGAP1 as a common target in variants of triple negative breast cancer

Innovative technology permits faster, cheaper toxicological screening of drug candidates

3D structure of Aβ protein assemblies reveals a new mechanism of toxicity

New polymeric heart valve is a promising alternative for valve replacement surgery, study shows

Human iPSCs: A Full Guide to Advanced in Vitro Models and Applications eBook

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

Expanding access to NMR with the Fourier 80 Duo

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