Immune Response News and Research

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Nasal version of AstraZeneca SARS-CoV-2 vaccine prevents infection in animal models

Scientists evaluate the use of ChAdOx1 nCoV-19 as a potential intranasal (IN) vaccine candidate in hamster and rhesus macaque models.

3 Aug 2021

Study shows COVID-19 organ-specific outcomes depend on anti-spike glycoprotein antibodies

A recent study from the University of Rochester reveals how the biodistribution kinetics and the affinity of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) for many different organs in the human body can be affected by antibodies targeting viral spike glycoprotein. The paper is currently available on the bioRxiv* preprint server while it undergoes peer review.

3 Aug 2021

SARS-CoV-2 Delta and Delta AY.1 variant show similar Covaxin-induced neutralization

A new study from India suggests that the Indian-made Covaxin whole-virus inactivated vaccine against the SARS-CoV-2 retains significant efficacy against the newer delta variants of the virus.

3 Aug 2021

Hormone-resistant prostate, breast cancers added to clinical trial of experimental DNA therapy

The Republic of Belarus Ministry of Health has approved expanding the ongoing clinical trial of CureLab Oncology's Elenagen, an experimental DNA therapy, to include two new arms: 1) hormone-resistant breast cancer; and 2) hormone-resistant metastatic prostate cancer.

3 Aug 2021

CHOP researchers identify two proteins that could be used for a potential NTHi vaccine

Scientists at Children's Hospital of Philadelphia have identified two proteins that could be used for a potential vaccine against nontypeable Haemophilus influenzae (NTHi).

2 Aug 2021

Cancer vaccine reduces tumor burden, improves survival in animal model of Lynch syndrome

A new strategy for developing vaccines against cancer showed promise in a proof-of-concept study led by scientists at Weill Cornell Medicine, NewYork-Presbyterian and Heidelberg University Hospital.

2 Aug 2021

Study reveals effective strategy to extend the benefit of immunotherapy for prostate cancer

It's a scientific riddle tangled up in a complex web. How do you turn an immune cold cancer into one that responds to immunotherapy?

2 Aug 2021

Intradermal administration of low-dose mRNA COVID-19 vaccine induces strong immune response, study finds

Scientists in the Netherlands recently conducted an open-level, randomized-controlled trial to evaluate the safety and immunogenicity of fractional intradermal doses of the mRNA-based COVID-19 vaccine mRNA-1273 (Moderna). The trial findings reveal that the fractional dose regimen of the Moderna vaccine is well tolerated and safe and is capable of inducing robust antibody responses in vaccine recipients. The study is currently available on the medRxiv* preprint server.

2 Aug 2021

Study connects hyperglycemia and prolonged cloth mask use to COVID-19-associated mucormycosis risk

A new study conducted in India identifies the role of high blood sugar levels in predisposing patients to mucormycosis infection.

1 Aug 2021

Newly identified genetic mutation causes rare, early onset inflammatory bowel disease

Johns Hopkins Medicine researchers, in collaboration with national and international researchers, have identified a genetic mutation in a small number of children with a rare type of inflammatory bowel disease.

30 Jul 2021

Prior SARS-CoV-2 infection enhances Johnson and Johnson Ad26.COV2.S vaccine immunogenicity

A new study reports that the Johnson and Johnson vaccine against COVID-19 shows enhanced efficacy when administered to individuals with pre-existing antibodies.

30 Jul 2021

In-silico prediction of effective drug combinations for the treatment of SARS-CoV-2 infection

A new study published on the bioRxiv preprint server has developed the first computational model, i.e., a signaling network model, that can predict effective repurposed drug combinations to treat different phases of COVID-19 disease. This study has focused on identifying drugs for the treatment of early- and late-stage severe disease.

30 Jul 2021

Scientists suspect Lambda SARS-CoV-2 variant most dangerous

A new study published on the bioRxiv* preprint server used molecular phylogenetic analysis to study the evolutionary trait of the Lambda variant.

30 Jul 2021

Study explains how SARS-CoV-2 variants differ in binding to ACE2 receptor

The current study explored ACE2-RBD interactions with four VoCs including the Alpha, Beta, Gamma, and Delta variants.

29 Jul 2021

Drug combination could make curative surgery possible for some liver cancer patients

A combination of the kinase-inhibitor drug cabozantinib and the immunotherapy drug nivolumab can make curative surgery possible in some liver cancer patients who would normally not be considered surgery candidates.

29 Jul 2021

Study examines the role of programmed cell death ligands in skin immune responses

T cells are a crucial part of the human adaptive immune system. In response to a foreign invader in the body, various subsets of T cells are responsible for several functions that include killing infected cells and secreting signaling molecules called cytokines that tell other immune cells where to go and what to do.

29 Jul 2021

99% of COVID-19 deaths in Italy occur among those not fully vaccinated

In a new report out of Italy, health officials reported that almost 99 percent of people who have died from COVID-19 since February 2021 were not fully vaccinated. The report released by the National Health Institute (ISS) showed that the few fully vaccinated people who died of COVID-19 were also older than those who died without complete COVID-19 vaccine doses.

29 Jul 2021

Prior SARS-CoV-2 infection enhances effectiveness of Pfizer-BioNTech vaccine

A study conducted by researchers in Qatar has found that Pfizer-BioNTech’s coronavirus disease 2019 (COVID-19) vaccine was more protective against infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) among individuals who had previously been infected with the virus than among those who had not.

29 Jul 2021

Antibacterial immunity may change in the intestines based on circadian cycle

The body's ability to prevent food poisoning by producing a natural antimicrobial compound increases during the day, when exposure to noxious bacteria is most likely, a new study by UT Southwestern scientists suggests.

28 Jul 2021

SARS-CoV-2 variants of concern employ different strategies of antibody escape

A recent study in the field of fluid analysis reveals a diverse set of strategies utilized by alpha and beta variants of the severe acute respiratory syndrome coronavirus 2 (SARS‑CoV‑2) in order to evade antibodies generated during an earlier infection with this virus. The paper is currently available on the bioRxiv* preprint server while it undergoes a peer-review process.

28 Jul 2021

Immune Response News and Research

Nasal version of AstraZeneca SARS-CoV-2 vaccine prevents infection in animal models

Study shows COVID-19 organ-specific outcomes depend on anti-spike glycoprotein antibodies

SARS-CoV-2 Delta and Delta AY.1 variant show similar Covaxin-induced neutralization

Hormone-resistant prostate, breast cancers added to clinical trial of experimental DNA therapy

CHOP researchers identify two proteins that could be used for a potential NTHi vaccine

Cancer vaccine reduces tumor burden, improves survival in animal model of Lynch syndrome

Study reveals effective strategy to extend the benefit of immunotherapy for prostate cancer

Intradermal administration of low-dose mRNA COVID-19 vaccine induces strong immune response, study finds

Study connects hyperglycemia and prolonged cloth mask use to COVID-19-associated mucormycosis risk

Newly identified genetic mutation causes rare, early onset inflammatory bowel disease

Prior SARS-CoV-2 infection enhances Johnson and Johnson Ad26.COV2.S vaccine immunogenicity

In-silico prediction of effective drug combinations for the treatment of SARS-CoV-2 infection

Scientists suspect Lambda SARS-CoV-2 variant most dangerous

Study explains how SARS-CoV-2 variants differ in binding to ACE2 receptor

Drug combination could make curative surgery possible for some liver cancer patients

Study examines the role of programmed cell death ligands in skin immune responses

99% of COVID-19 deaths in Italy occur among those not fully vaccinated

Prior SARS-CoV-2 infection enhances effectiveness of Pfizer-BioNTech vaccine

Antibacterial immunity may change in the intestines based on circadian cycle

SARS-CoV-2 variants of concern employ different strategies of antibody escape

Industry Focus eBook - Cell & Gene Therapy (1st Edition) eBook

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

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