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Researchers identify gene variant that affects onset of Huntington's disease

Researchers at Sweden's Karolinska Institutet and the University of British Columbia, Canada, have identified a gene variant that influences whether Huntington's disease breaks out earlier or later than expected. The findings, which are published in the scientific journal Nature Neuroscience, can contribute to improved diagnosis and disease-modifying therapies.

5 May 2015

New understanding of how Huntington's disease gene works

Huntington's disease is caused by a mutation in the Huntington's disease gene, but it has long been a mystery why some people with the exact same mutation get the disease more severely and earlier than others. A closer look at the DNA around the Huntington's disease (HD) gene offers researchers a new understanding of how the gene is controlled and how this affects the disease.

5 May 2015

High Throughput ChIP-seq Assay for Genome-wide Protein-DNA Analysis

Chromatrap®, a business unit of Porvair Sciences, has published a new application note that describes how Chromatrap® ChIP-seq assays now enable unbiased, genome-wide understanding of protein-DNA regulatory networks...

From Chromatrap® - Porvair Sciences Ltd 30 Apr 2015

Study finds that gene therapy can clip out genetic material associated with heart failure

Gene therapy can clip out genetic material linked to heart failure and replace it with the normal gene in human cardiac cells, according to a study led by researchers from the Cardiovascular Research Center at Icahn School of Medicine at Mount Sinai.

30 Apr 2015

Link between dDsk2 protein and neurodegenerative diseases identified

Until today, the proteins known as ubiquitin receptors have been associated mainly with protein degradation, a basic cell cleaning process. A new function now described for the protein dDsk2 by the team headed by Ferran Azorín, group leader at the Institute for Research in Biomedicine (IRB Barcelona) and CSIC research professor, links ubiquitin receptors for the first time with the regulation of gene expression.

29 Apr 2015

Researchers discover key mechanism in neural death that causes Parkinson's disease

In studying the molecular biology of brain development, a team of researchers led by Ludwig Stockholm director Thomas Perlmann has discovered how disruption of a developmental mechanism alters the very nerve cells that are most affected in Parkinson's disease.

29 Apr 2015

TSRI study provides new insight into preventing diseases that cause vision loss in adults

A new study from scientists at The Scripps Research Institute shows that nerve cells and blood vessels in the eye constantly "talk" to each other to maintain healthy blood flow and prevent disease.

28 Apr 2015

Study explores innovative approach to identifying successful treatment for HER2+ breast cancer

Ahmad M. Khalil, PhD, knew the odds were against him -- as in thousands upon thousands to one. Yet he and his team never wavered from their quest to identify the parts of the body responsible for revving up one of the most aggressive forms of breast cancer, HER2+. This month in Breast Cancer Research and Treatment, Khalil and his colleagues at Case Western Reserve University proved the power of persistence; from a pool of more than 30,000 possibilities, they found 38 genes and molecules that most likely trigger HER2+ cancer cells to spread.

25 Apr 2015

Insulin signaling pathway has significant influence on the growth of glioblastomas

Drugs that target insulin pathways to slow or stop the growth of brain tumors are going in the right direction but appear to be on the wrong track, according to new research at Rice University.

21 Apr 2015

UAB research findings may lead to better treatment for women with HER2+ breast cancer

There are five subtypes of breast cancer, and they are distinct diseases with vastly different biologies that drastically alter their progression and responses to treatment. Understanding those differences is the starting point to a more effective, personalized treatment of breast cancer, which strikes more than 230,000 women in the U.S. each year.

16 Apr 2015

SELLAS inks exclusive global collaboration, license agreement with TrojanTec

SELLAS Life Sciences Group, a Swiss based, development-stage biopharmaceutical company with its main focus in developing innovative products for the treatment of various indications in Oncology and the Central Nervous System, today announced that it has signed an exclusive global collaboration and license agreement with TrojanTec Ltd, a UK-based Discovery Research and Development Company affiliated with Imperial College London, UK, for the development, marketing and commercialization of the innovative and proprietary TR-1 cancer therapeutic technology and drug.

15 Apr 2015

New study describes way to regenerate lung tissue after injury

A new collaborative study describes a way that lung tissue can regenerate after injury. The team found that lung tissue has more dexterity in repairing tissue than once thought.

13 Apr 2015

Inova Diagnostics gains FDA de novo clearance for NOVA View automated digital IFA microscope

Inova Diagnostics, the worldwide leader in autoimmune diagnostic reagents and systems for the clinical laboratory, announced today that the United States Food and Drug Administration has cleared NOVA View, an automated digital IFA (indirect fluorescent assay) microscope, through the de novo classification process.

12 Apr 2015

New combination therapy holds promise for treating HER2-positive breast cancer

Resistance to therapy is a major problem in the cancer field. Even when a treatment initially works, the tumors often find ways around the therapy.

10 Apr 2015

Neuro-oncology researchers identify mechanism responsible for tumor cell invasion in glioblastoma

A neuro-oncology research team at Dartmouth's Norris Cotton Cancer Center, led by the Director Mark A. Israel, MD with first author Gilbert J. Rahme, PhD, recently identified the transcription factor Id4 as a suppressor of tumor cell invasion in glioblastoma.

9 Apr 2015

High Throughput ChIP Sequencing

Chromatrap®, a business unit of Porvair Sciences, has announced a major product launch at the European Human Genetics Conference (Glasgow, UK) and the Festival of Genomics (Boston, USA) on the 6th June 2015 and 22nd-24th June 2015 respectively

From Chromatrap® - Porvair Sciences Ltd 6 Apr 2015

Researchers discover genetic factors key to POMC cells

The little voice inside your head that tells you to eat, or stop eating, isn't a little voice - it's actually a cluster of about 10,000 specialized brain cells. And now, an international team of scientists has found tiny triggers inside those cells that give rise to this "voice", and keep it speaking throughout life.

6 Apr 2015

Combination of signaling molecules can inhibit growth of breast cancer cells

Researchers at UT Southwestern Medical Center have uncovered how the body's inflammatory response can alter how estrogen promotes the growth of breast cancer cells.

6 Apr 2015

Researchers pinpoint molecular mechanisms that inhibit Hippo pathway in pediatric bone cancers

A particular molecular pathway permits stem cells in pediatric bone cancers to grow rapidly and aggressively, according to researchers at NYU Langone Medical Center and its Laura and Isaac Perlmutter Cancer Center.

2 Apr 2015

Penn Med's BLINKER Team named one of 16 finalists in NIH 'Follow that Cell Challenge'

James Eberwine, PhD, the Elmer Holmes Bobst Professor of Systems Pharmacology and Experimental Therapeutics, at the Perelman School of Medicine at the University of Pennsylvania, was named one of 16 finalists in the first phase of the Follow that Cell Challenge funded by the National Institutes of Health. The competition was run by crowdsourcing company Innocentive and 687 designated "solvers" entered initially.

2 Apr 2015

Transcription News and Research

Researchers identify gene variant that affects onset of Huntington's disease

New understanding of how Huntington's disease gene works

High Throughput ChIP-seq Assay for Genome-wide Protein-DNA Analysis

Study finds that gene therapy can clip out genetic material associated with heart failure

Link between dDsk2 protein and neurodegenerative diseases identified

Researchers discover key mechanism in neural death that causes Parkinson's disease

TSRI study provides new insight into preventing diseases that cause vision loss in adults

Study explores innovative approach to identifying successful treatment for HER2+ breast cancer

Insulin signaling pathway has significant influence on the growth of glioblastomas

UAB research findings may lead to better treatment for women with HER2+ breast cancer

SELLAS inks exclusive global collaboration, license agreement with TrojanTec

New study describes way to regenerate lung tissue after injury

Inova Diagnostics gains FDA de novo clearance for NOVA View automated digital IFA microscope

New combination therapy holds promise for treating HER2-positive breast cancer

Neuro-oncology researchers identify mechanism responsible for tumor cell invasion in glioblastoma

High Throughput ChIP Sequencing

Researchers discover genetic factors key to POMC cells

Combination of signaling molecules can inhibit growth of breast cancer cells

Researchers pinpoint molecular mechanisms that inhibit Hippo pathway in pediatric bone cancers

Penn Med's BLINKER Team named one of 16 finalists in NIH 'Follow that Cell Challenge'

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

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