Immune Response News and Research

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Researchers identify novel disorder resulting from a mutation in AIOLOS protein

Primary immunodeficiencies, such as severe combined immunodeficiency disease (SCID), occur when the immune system does not work properly, leading to increased susceptibility to various infections, autoimmunity, and cancers.

16 Jul 2021

Psychiatric patients have higher odds of hospitalization and death following COVID-19

In the largest systematic review and meta-analysis to date on COVID-19 outcomes in individuals with psychiatric disorders, the odds of dying or being hospitalized following COVID-19 infection were determined to be twice as high in comparison to persons without mental disorders.

16 Jul 2021

UK study finds brain or nerve complications in 1 in 20 of children hospitalized with COVID-19

Although the risk of a child being admitted to hospital due to COVID-19 is small, a new UK study has found that around 1 in 20 of children hospitalized with COVID-19 develop brain or nerve complications linked to the viral infection.

16 Jul 2021

RUDN University biologists discover the way how macrophages respond to inflammation

RUDN University biologists discovered the way how macrophages (the cells of the "first line" immune response) respond to inflammation and identified how the immune response depends on their origin.

16 Jul 2021

Moderna SARS-CoV-2 vaccine highly effective against alpha and beta variants

The Moderna SARS-CoV-2 vaccine was widely distributed and had a reported efficacy in clinical trials of 94.1% against the wildtype SARS-CoV-2 following the second dose administration. Therefore, Chemaitelly et al. used this as an opportunity to measure the vaccine's efficacy against these variants as reported in a recent Nature Medicine paper, finding that the vaccine has good efficacy in all aspects.

16 Jul 2021

Mixing COVID vaccines generates a comparable immune response

The validity and safety of mixing first and second doses of different types are explored in a paper recently uploaded to the preprint server medRxiv* by Rose et al. (July 13th, 2021), finding that robust antibody response is induced, comparable to, and perhaps even exceed that generated by homologous dosing.

16 Jul 2021

COVID-19 vaccine candidate that can be produced in yeast proves effective in macaques

Researchers in the United States have designed a modular protein subunit vaccine against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) that elicited a strong immune response in macaques and prevented the animals from developing coronavirus disease 2019 (COVID-19).

15 Jul 2021

Researchers find a promising avenue for more effective treatment of antibiotic-resistant bacteria

A small regulatory RNA found in many problematic bacteria, including Escherichia coli, appears to be responsible for managing the response of these bacteria to environmental stresses.

15 Jul 2021

New OMV-based COVID-19 vaccine candidate proves effective in mice

Researchers in Italy have demonstrated the efficacy of using modified outer membrane vesicles (OMVs) as a vaccine to protect against coronavirus disease 2019 (COVID-19) in an animal model.

14 Jul 2021

Fungi that live in the gut may be equally important in health and disease

Bacteria's role in gut health has received a lot of attention in recent years. But new research led by scientists at University of Utah Health shows that fungi - another microorganism that lives within us - may be equally important in health and disease.

14 Jul 2021

Minimally invasive exosome spray may help repair the heart after myocardial infarction

Heart attack, or myocardial infarction, is one of the leading causes of death worldwide. Although modern surgical techniques, diagnostics and medications have greatly improved early survival from these events, many patients struggle with the long-term effects of permanently damaged tissue, and the 5-year mortality rate remains high.

14 Jul 2021

Could corticosteroids increase mortality in COVID-19 patients without high oxygen supplementation?

A new paper focuses on the role of corticosteroids, in particular, as these were widely used among patients on intensive respiratory support (IRS).

14 Jul 2021

Nanopore technology allows point-of-care SARS-CoV-2 genomic sequencing

As the SARS-CoV-2 continues to spread worldwide and cause disease and death on a devastating scale, genomic sequencing has become a primary method of keeping track of emerging variants and new outbreaks. A new medRxiv* preprint explores the role of nanopore sequencing in this effort.

14 Jul 2021

Fungi and bacteria in the gut may equally impact human health and disease severity

The gut microbiome has received a lot of attention, but research shows that fungi in the gut is also an important microorganism in gut functioning and health.

14 Jul 2021

SARS-CoV-2 variants show distinct humoral response and transcriptional profiles in hamster model

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a novel, highly infectious respiratory virus, and the causative agent of coronavirus disease 2019 (COVID-19) pandemic. SARS-CoV-2, which first originated in Wuhan, in Hubei province of China, is a member of the Coronavirdae family and has a large, non-segmented RNA genome.

14 Jul 2021

Scientists identify existing drugs that may inhibit SARS-CoV-2 virus

The COVID-19 pandemic has caused more than 600,000 deaths in the United States since the start of 2020 and more than 4 million globally.

13 Jul 2021

Colonization by SARS-CoV-2 not synonymous with infection, screening study highlights

A new study released as a preprint on the medRxiv* server throws cold water on this notion, however, by demonstrating that in a set of asymptomatic cases, less than a tenth actually had evidence of SARS-CoV-2 infection. This finding has serious implications for the practices mentioned above, since they may be neither justifiable nor cost-effective as means to break the chain of viral transmission.

13 Jul 2021

“React and inject”: synthetic peptide-modified nanodiamonds as emergency pan-coronavirus vaccines

A recent study published in the MDPI journal, Pathogens, describes a coronavirus peptide vaccine antigen in the form of nanodiamond-based formulations, that demonstrated a robust and long-lasting immune response. The nanodiamonds proved to be a powerful and versatile platform for antigen conjugation. This could make it a safe and effective strategy for the production of off-the-shelf vaccines against multiple coronaviruses.

13 Jul 2021

Nose drops of modified 'friendly' bacteria offer protection against meningitis

A world-first trial has shown that nose drops of modified 'friendly' bacteria protect against meningitis.

12 Jul 2021

mRNA-based COVID-19 vaccine CV07050101 demonstrates limited immunogenicity in non-human primates

Scientists from the US and Germany have recently evaluated the efficacy of an mRNA-based COVID-19 vaccine candidate, CV07050101, in inducing humoral and cellular immune responses in non-human primates. The study reveals that prime-boost immunization with the vaccine candidate induces only limited immunity against SARS-CoV-2.

12 Jul 2021

Immune Response News and Research

Researchers identify novel disorder resulting from a mutation in AIOLOS protein

Psychiatric patients have higher odds of hospitalization and death following COVID-19

UK study finds brain or nerve complications in 1 in 20 of children hospitalized with COVID-19

RUDN University biologists discover the way how macrophages respond to inflammation

Moderna SARS-CoV-2 vaccine highly effective against alpha and beta variants

Mixing COVID vaccines generates a comparable immune response

COVID-19 vaccine candidate that can be produced in yeast proves effective in macaques

Researchers find a promising avenue for more effective treatment of antibiotic-resistant bacteria

New OMV-based COVID-19 vaccine candidate proves effective in mice

Fungi that live in the gut may be equally important in health and disease

Minimally invasive exosome spray may help repair the heart after myocardial infarction

Could corticosteroids increase mortality in COVID-19 patients without high oxygen supplementation?

Nanopore technology allows point-of-care SARS-CoV-2 genomic sequencing

Fungi and bacteria in the gut may equally impact human health and disease severity

SARS-CoV-2 variants show distinct humoral response and transcriptional profiles in hamster model

Scientists identify existing drugs that may inhibit SARS-CoV-2 virus

Colonization by SARS-CoV-2 not synonymous with infection, screening study highlights

“React and inject”: synthetic peptide-modified nanodiamonds as emergency pan-coronavirus vaccines

Nose drops of modified 'friendly' bacteria offer protection against meningitis

mRNA-based COVID-19 vaccine CV07050101 demonstrates limited immunogenicity in non-human primates

Exploring Strategies for Targeting Kinases in Innate Immunity eBook

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

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