Syndrome News and Research

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CRISPR/Cas9-engineered avatar mouse model of rare disease paves the way for targeted therapy

An international research team led by Dr Ana Guadaño at the Alberto Sols Biomedical Research Institute (IIBM, a combined CSIC-UAM center) and involving the Complutense University of Madrid (UCM), used CRISPR gene editing techniques to incorporate into the mice a mutation of the MCT8 protein responsible for transporting thyroid hormones to the interior of the cell.

12 Dec 2022

People with Alzheimer’s and Down syndrome may benefit from participating in Alzheimer’s clinical trials

Amyloid plaques — protein clumps that are one of the hallmarks of Alzheimer's disease—occur at roughly the same level in the brains of people with Down syndrome who have Alzheimer's as they do in people with forms of hereditary, early-onset Alzheimer's, according to research funded by the National Institutes of Health.

12 Dec 2022

COVID-19 vaccination temporarily alters heart rate variability

HRV parameters after COVID-19 vaccination show significant short-term changes that may persist for up to three days until ultimately returning to baseline.

12 Dec 2022

Detection of unreported infections based on SARS-CoV-2 antibody seroprevalence

Researchers analyzed data from SARS-CoV-2 seroprevalence studies to elucidate the nationwide temporal trends of COVID-19 prevalence.

12 Dec 2022

Immunogenicity of SARS-CoV-2 antibody response in immune naïve children and adults

Researchers compare the contribution of antibodies against the SARS-CoV-2 receptor binding domain in vaccinated and naturally infected adults and children.

12 Dec 2022

XBB Omicron variant evades vaccine-induced immunity

A new study published in The Lancet Microbe examines the immune evasion characteristics of the Omicron XBB subvariant.

12 Dec 2022

Researchers show link between a debilitating heart condition and COVID-19 infection, vaccination

Investigators from the Smidt Heart Institute at Cedars-Sinai validated the link between a debilitating heart condition and COVID-19 and, to a lesser extent, a novel link between the same condition and COVID-19 vaccination.

12 Dec 2022

Light therapy could be a promising non-drug treatment option for multiple sclerosis-related fatigue

Multiple Sclerosis (MS) is almost always accompanied by fatigue, a massive tiredness that is described by the vast majority of patients as the most distressing symptom.

12 Dec 2022

Novel wearable device can monitor physiological parameters associated with heart failure in real-time

There are about 64 million cases of heart failure worldwide. According to the American Heart Association, 6.2 million adults in the United States have heart failure and that number is estimated to increase to 8 million by 2030.

12 Dec 2022

Simplified treatment regimen results in dramatic decrease in early deaths from acute promyelocytic leukemia

The use of a simplified treatment regimen by oncologists, along with management recommendations and 24/7 support provided by a limited and dedicated group of academic disease experts, resulted in a dramatic decrease in early deaths from acute promyelocytic leukemia (APL).

12 Dec 2022

Many genetic disorders respond well to specialized gene therapy

When the normal DNA sequence in an individual changes or mutates it can cause disease. The mutation may involve multiple genes and may be caused by environmental factors, or there may be chromosomal defects that are harmful at birth, in infancy or environment at a later stage.

12 Dec 2022

What are the patterns of symptoms and risk factors for Long COVID among SARS-CoV-2 infected individuals?

Researchers explored the indicators of long COVID symptoms.

12 Dec 2022

Research reveals the assembly dynamics of nucleocapsid protein condensates can be regulated by small molecules with therapeutic potential

Researchers developed a screening platform and identified molecules with anti-CoV activity.

12 Dec 2022

Extra year of chemotherapy lowers the risk of cancer recurrence in children with Ikaros leukemia

Many children with ALL have a good outcome of their disease. After two years of chemotherapy treatment, nine out of ten children are cured. But some children have a more aggressive form of the disease.

12 Dec 2022

Bioengineered soluble ACE2 for brain protection against SARS-CoV-2 infection

Researchers compared the efficiency of bioengineered soluble ACE-2 concerning brain protection during COVID-19.

12 Dec 2022

The benefit-risk of the mRNA-1273 COVID-19 vaccine

Researchers modeled the benefit-risk of Moderna’s COVID-19 mRNA-1273 vaccine.

12 Dec 2022

Aging influences the diagnosis and treatment of heart attacks in patients over age 75

For people ages 75 and older, age-related changes in general health and in the heart and blood vessels require consideration and likely modifications in how heart attacks and heart disease are treated, according to a new American Heart Association scientific statement published today in the Association's flagship, peer-reviewed journal Circulation.

12 Dec 2022

Study shows emerging Omicron sublineages efficiently evade neutralization independent of immunization history

Researchers evaluated the effects of hybrid immunity and booster vaccination on Omicron sublineages.

12 Dec 2022

What is the incidence of viral rebound after treatment with nirmatrelvir-ritonavir and molnupiravir?

Researchers evaluated the incidence of COVID-19 rebound among SARS-CoV-2 -positive patients treated with oral antiviral drugs such as nirmatrelvir-ritonavir combination and molnupiravir.

12 Dec 2022

Ongoing Phase I clinical trial demonstrates successful re-treatment with CAR T cell therapy

Researchers from the University of Pennsylvania's Abramson Cancer Center presented preliminary results of an ongoing Phase I clinical trial demonstrating successful re-treatment with CAR T cell therapy for patients whose cancers relapsed after previous CAR T therapy at the 2022 American Society of Hematology Annual Meeting.

12 Dec 2022

Syndrome News and Research

CRISPR/Cas9-engineered avatar mouse model of rare disease paves the way for targeted therapy

People with Alzheimer’s and Down syndrome may benefit from participating in Alzheimer’s clinical trials

COVID-19 vaccination temporarily alters heart rate variability

Detection of unreported infections based on SARS-CoV-2 antibody seroprevalence

Immunogenicity of SARS-CoV-2 antibody response in immune naïve children and adults

XBB Omicron variant evades vaccine-induced immunity

Researchers show link between a debilitating heart condition and COVID-19 infection, vaccination

Light therapy could be a promising non-drug treatment option for multiple sclerosis-related fatigue

Novel wearable device can monitor physiological parameters associated with heart failure in real-time

Simplified treatment regimen results in dramatic decrease in early deaths from acute promyelocytic leukemia

Many genetic disorders respond well to specialized gene therapy

What are the patterns of symptoms and risk factors for Long COVID among SARS-CoV-2 infected individuals?

Research reveals the assembly dynamics of nucleocapsid protein condensates can be regulated by small molecules with therapeutic potential

Extra year of chemotherapy lowers the risk of cancer recurrence in children with Ikaros leukemia

Bioengineered soluble ACE2 for brain protection against SARS-CoV-2 infection

The benefit-risk of the mRNA-1273 COVID-19 vaccine

Aging influences the diagnosis and treatment of heart attacks in patients over age 75

Study shows emerging Omicron sublineages efficiently evade neutralization independent of immunization history

What is the incidence of viral rebound after treatment with nirmatrelvir-ritonavir and molnupiravir?

Ongoing Phase I clinical trial demonstrates successful re-treatment with CAR T cell therapy

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

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