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Schizophrenia-linked genetic variations and the developing brain: an interview with Prof. Guo-li Ming

How much is currently known about what happens in the developing brain that puts people at risk of schizophrenia?

11 Aug 2014

Scientists identify mechanism by which inherited neurological disease causes muscle weakness in men

Researchers at University of California, San Diego School of Medicine have identified the mechanism by which a rare, inherited neurodegenerative disease causes often crippling muscle weakness in men, in addition to reduced fertility.

11 Aug 2014

Altering the circadian rhythm: an interview with Dr. Doug Kojetin, The Scripps Research Institute

The circadian rhythm is affected by many different stimuli—such as sleep and light, which are the most broadly appreciated ways—but also eating— all of which can modulate, or change, important processes in our bodies such as temperature, production of hormones or other signalling small molecules, cellular regeneration, and others.

6 Aug 2014

Study provides platform for detailed study of nerve injury and repair during Wallerian degeneration

Wallerian degeneration is a subject of major interest in neuroscience. A large number of genes are differentially regulated during the distinct stages of Wallerian degeneration: transcription factor activation, immune response, myelin cell differentiation and dedifferentiation.

31 Jul 2014

Xbp1s protein plays key role in brain regions to regulate metabolism

A protein that controls when genes are switched on or off plays a key role in specific areas of the brain to regulate metabolism, UT Southwestern Medical Center researchers have found.

26 Jul 2014

Study identifies molecular mechanisms could lead to new therapies to treat obesity, diabetes

A protein that controls when genes are switched on or off plays a key role in specific areas of the brain to regulate metabolism, UT Southwestern Medical Center researchers have found.

25 Jul 2014

New chromatin immunoprecipitation sequencing kit developed by Porvair Sciences

Porvair Sciences has developed a new ChIP sequencing assay kit extending the benefits of their proprietary Chromatrap® solid state ChIP technology to preparation of purified Chromatin for the generation of sequencing libraries.

From Chromatrap® - Porvair Sciences Ltd 22 Jul 2014

Saudi Arabian researchers detect genetic fragments of MERS-CoV in the air of camel barn

Saudi Arabian researchers have detected genetic fragments of Middle East Respiratory Syndrome coronavirus (MERS-CoV) in the air of a barn holding a camel infected with the virus. The work, published this week in mBio-, the online open-access journal of the American Society for Microbiology, indicates that further studies are needed to see if the disease can be transmitted through the air.

22 Jul 2014

A personalized approach for patients with ccRCC-related mutations

In an analysis of small molecules called metabolites used by the body to make fuel in normal and cancerous cells in human kidney tissue, a research team from the Perelman School of Medicine at the University of Pennsylvania identified an enzyme key to applying the brakes on tumor growth.

21 Jul 2014

Researchers identify key explanation for why immune system unsuccessful in killing HIV virus

Our immune system contains CD8+ T cells which protect us from various diseases such as cancer and viruses. Some of them are specifically tasked with killing cells infected with the HIV virus - and researchers from Karolinska Institutet in Sweden, together with international colleagues, have for the first time identified a key explanation for why these cells are unsuccessful in their task.

18 Jul 2014

TAZ represents a novel therapeutic target in NSCLC

Patients with non-small-cell lung cancer who express high levels of transcriptional coactivator with PDZ-binding motif may be a clinically distinct subgroup with an unfavourable prognosis, researchers report.

16 Jul 2014

Thirteen scientists receive grant to identify new treatments, cure for psoriasis

Thirteen scientists received a total of $1.05 million in funding from the National Psoriasis Foundation for projects that aim to identify new treatments and a cure for psoriasis—an autoimmune disease that appears on the skin, affecting 7.5 million Americans—and psoriatic arthritis—an inflammatory arthritis that affects the joints and tendons, occurring in up to 30 percent of people with psoriasis.

16 Jul 2014

New genetic programs for taking blank-slate stem cells and turning them into human blood

The ability to reliably and safely make in the laboratory all of the different types of cells in human blood is one key step closer to reality.

14 Jul 2014

Research uncovers how complex protein pivotal in cancer development is activated

New research has uncovered how a complex protein pivotal in the development of cancer, viral infection and autoimmune diseases is activated.

10 Jul 2014

MEF2 gene: A potential therapeutic target to protect neuronal loss in Alzheimer's, Parkinson's

A new study by researchers at Sanford-Burnham Medical Research Institute (Sanford-Burnham) has identified a chemical "switch" that controls both the generation of new neurons from neural stem cells and the survival of existing nerve cells in the brain.

4 Jul 2014

Transcription factor IRF4 plays key role in brown fat's thermogenic process

The body contains two types of fat cells, easily distinguished by color: White and brown. While white fat serves to store excess calories until they're needed by the body, brown adipocytes actually burn fat by turning it into heat.

4 Jul 2014

Scientists find unexpected degree of complexity in transcriptional enhancers’ interactions

Contrary to what was thought, sequences of DNA called enhancers - which control a gene's output - find their targets long before they are activated during embryonic development, scientists at the European Molecular Biology Laboratory (EMBL) in Heidelberg, Germany, have found.

4 Jul 2014

Thyroxine may overcome mutated thyroid hormone receptor effects

Patients with a mutation in the thyroid hormone receptor α gene that affects both the thyroid hormone receptor α1 and α2 protein variants have similar characteristics to patients with mutations affecting only the α1 variant, report researchers.

3 Jul 2014

Study explores new ways to improve medications to treat type 2 diabetes

A better understanding of how the transcription factor Peroxisome Proliferator-Activated Receptor Gamma (PPARgamma) works is critical to find new ways to improve medications to treat type 2 diabetes.

23 Jun 2014

Yap1 oncogene drives recurrence and progression of pancreatic cancer

Pancreatic cancer tumors addicted to mutant Kras signaling for their growth and progression have a ready-made substitute to tap if they're ever forced to go cold-turkey on the mutant oncogene, scientists at The University of Texas MD Anderson Cancer Center report in the journal Cell.

20 Jun 2014

Transcription News and Research

Schizophrenia-linked genetic variations and the developing brain: an interview with Prof. Guo-li Ming

Scientists identify mechanism by which inherited neurological disease causes muscle weakness in men

Altering the circadian rhythm: an interview with Dr. Doug Kojetin, The Scripps Research Institute

Study provides platform for detailed study of nerve injury and repair during Wallerian degeneration

Xbp1s protein plays key role in brain regions to regulate metabolism

Study identifies molecular mechanisms could lead to new therapies to treat obesity, diabetes

New chromatin immunoprecipitation sequencing kit developed by Porvair Sciences

Saudi Arabian researchers detect genetic fragments of MERS-CoV in the air of camel barn

A personalized approach for patients with ccRCC-related mutations

Researchers identify key explanation for why immune system unsuccessful in killing HIV virus

TAZ represents a novel therapeutic target in NSCLC

Thirteen scientists receive grant to identify new treatments, cure for psoriasis

New genetic programs for taking blank-slate stem cells and turning them into human blood

Research uncovers how complex protein pivotal in cancer development is activated

MEF2 gene: A potential therapeutic target to protect neuronal loss in Alzheimer's, Parkinson's

Transcription factor IRF4 plays key role in brown fat's thermogenic process

Scientists find unexpected degree of complexity in transcriptional enhancers’ interactions

Thyroxine may overcome mutated thyroid hormone receptor effects

Study explores new ways to improve medications to treat type 2 diabetes

Yap1 oncogene drives recurrence and progression of pancreatic cancer

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

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