Severe Acute Respiratory News and Research

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T-cell response to Omicron after an mRNA COVID vaccine booster

In a recent prospective observational study posted to the medRxiv* preprint server, researchers determined Omicron variant-associated T cell responses before and after a third dose of messenger ribonucleic acid (mRNA) vaccination against coronavirus disease (COVID-19) in anti-CD20-treated multiple sclerosis (MS) patients.

22 Dec 2021

More breakthrough infections but less severe COVID-19 with Omicron

In a recent study posted to the bioRxiv* pre-print server, an international team of researchers reported the occurrence of coronavirus disease 2019 (COVID-19) breakthrough infections (BTIs) among health care workers (HCWs) participating in a phase III vaccine trial in Sisonke, South Africa.

22 Dec 2021

Infect, replicate, and rapidly mutate: Computational virus modeling study

A new bioRxiv* preprint study led by Barbara A Jones of IBM Research-Almaden in San Jose, California, used computational modeling to investigate how viruses rapidly mutate as well as how they respond or adapt to different host conditions. They observed a range of behaviors from glassy dynamics, bimodal quasispecies distributions, and periodic steady states.

22 Dec 2021

Protein-based nanoparticle vaccines for protection against SARS-CoV-2

A recent review article discusses recent advances in protein-based nanoparticle vaccines against SARS-CoV-2.

22 Dec 2021

COVID can affect sperm quality for three months

Researchers determine whether SARS-CoV-2 could cross the blood-testis barrier and be detected in human semen after infection.

22 Dec 2021

How COVID vaccines protected Americans against the Delta variant

A new study analyzed the COVID-19 breakthrough case and death rates among fully vaccinated individuals who were 12 years of age or above.

22 Dec 2021

rVSV-based bivalent vaccine against SARS-CoV-2 delta variant and influenza

Researchers developed four distinct recombinant vesicular stomatitis virus (rVSV)-based bivalent vaccines against SARS-CoV-2 and influenza virus.

22 Dec 2021

Study confirms coronavirus RNA synthesis occurs inside membrane-bound compartments

Researchers have experimentally proved that virus-related double-stranded RNA (dsRNA) and the sites of viral RNA synthesis are associated with one another.

22 Dec 2021

Importance of booster vaccine doses for maintaining protection against the SARS-CoV-2 Omicron variant

A new study shows that although the Omicron variant exhibits significant immune escape compared to other SARS-CoV-2 variants, antibody neutralization can be largely restored with booster doses of mRNA vaccines.

22 Dec 2021

Role of novel SARS-CoV-2-derived svRNAs and the involvement of tRF in COVID-19

A new study revealed new long sv-COV-2 using T4 PNK pretreatment and qRT-PCR and also identified piRNAs and tRFs as the most abundant sncRNAs in COVID-19 positive samples.

22 Dec 2021

Omicron evades roughly twice the number of SARS-CoV-2 neutralizing antibodies than Delta

New study results highlight that Omicron has an increased affinity to ACE-2 receptors, therefore, has increased infectivity, viral load, and transmissibility compared to other variants of concern, including the Delta variant.

22 Dec 2021

Extended interval between second and third vaccination beneficial against SARS-CoV-2 Omicron variant

A new study proposes a multi-boost vaccine strategy with a longer duration between the second and third dose, as that would be beneficial in acquiring immunity against severely mutated SARS-CoV-2 variants.

22 Dec 2021

Study suggests nitazoxanide fails to reduce the severity of SARS-CoV-2

A new study shows that the optimization of nitazoxanide formulations may allow the review of the potential use of the drug for the treatment of SARS-CoV-2 infection.

22 Dec 2021

Scientists identify a panel of nanobodies with good neutralizing efficacy against SARS-CoV-2 variants of concern

A team of scientists from Canada has recently characterized a panel of nanobodies against the spike protein of SARS-CoV-2.

22 Dec 2021

Defensosomes can act as decoys to protect against SARS-CoV-2

In a new study, researchers from New York University have been examining the ability of defensosomes to combat SARS-CoV-2 infection.

22 Dec 2021

Furin cleavage site similarities in SARS-CoV-2 and rodent coronavirus indicate common wildlife host

New study findings show that AcCoV-JC34 is the only luchacovirus containing a –RR-R- motif that is identical to the one found in SARS-CoV-2.

22 Dec 2021

Exploring the Mediterranean diet as a potential strategy against SARS-CoV-2

A study found that the Mediterranean diet, when combined with non-smoking and regular physical activity, can lower susceptibility to SARS-CoV-2.

22 Dec 2021

Importance of pneumococcal vaccination during the COVID-19 pandemic

A new study discusses the necessity and role of pneumococcal immunization in strengthening the global health system amid the current COVID-19 pandemic.

22 Dec 2021

Two-dose ChAdOx1 vaccine protection wanes after three months

New research reported in the journal The Lancet examines the temporal association between the two-dose ChAdOx1 nCoV-19 (Oxford-AstraZeneca) vaccination regimen and the risk of severe outcomes from COVID-19 in Scotland vs. Brazil, where the Delta variant of SARS-CoV-2 was dominant and rare, respectively.

21 Dec 2021

Broad neutralization of SARS-CoV-2 spike protein by an unconventional antibody fragment

A new preprint research paper posted to the bioRxiv* server examines the nature and effects of the spike mutations and identifies a vulnerable point that could help develop broad-spectrum protection against circulating variants.

21 Dec 2021

Severe Acute Respiratory News and Research

T-cell response to Omicron after an mRNA COVID vaccine booster

More breakthrough infections but less severe COVID-19 with Omicron

Infect, replicate, and rapidly mutate: Computational virus modeling study

Protein-based nanoparticle vaccines for protection against SARS-CoV-2

COVID can affect sperm quality for three months

How COVID vaccines protected Americans against the Delta variant

rVSV-based bivalent vaccine against SARS-CoV-2 delta variant and influenza

Study confirms coronavirus RNA synthesis occurs inside membrane-bound compartments

Importance of booster vaccine doses for maintaining protection against the SARS-CoV-2 Omicron variant

Role of novel SARS-CoV-2-derived svRNAs and the involvement of tRF in COVID-19

Omicron evades roughly twice the number of SARS-CoV-2 neutralizing antibodies than Delta

Extended interval between second and third vaccination beneficial against SARS-CoV-2 Omicron variant

Study suggests nitazoxanide fails to reduce the severity of SARS-CoV-2

Scientists identify a panel of nanobodies with good neutralizing efficacy against SARS-CoV-2 variants of concern

Defensosomes can act as decoys to protect against SARS-CoV-2

Furin cleavage site similarities in SARS-CoV-2 and rodent coronavirus indicate common wildlife host

Exploring the Mediterranean diet as a potential strategy against SARS-CoV-2

Importance of pneumococcal vaccination during the COVID-19 pandemic

Two-dose ChAdOx1 vaccine protection wanes after three months

Broad neutralization of SARS-CoV-2 spike protein by an unconventional antibody fragment

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