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New brain targets for GLP1-based obesity drugs may reduce weight without nausea

Researchers identified distinct hindbrain GLP1R neurons driving satiety and aversion, offering new targets for effective, side-effect-free obesity treatments.

14 Jul 2024

Study reveals how inflammation weakens muscles during illness

Infections and neurodegenerative diseases cause inflammation in the brain. But for unknown reasons, patients with brain inflammation often develop muscle problems that seem to be independent of the central nervous system. Now, researchers at Washington University School of Medicine in St. Louis have revealed how brain inflammation releases a specific protein that travels from the brain to the muscles and causes a loss of muscle function.

13 Jul 2024

Testing the effectiveness of youth activism as a mental health intervention

Three hundred Black and Latinx teens in Chicago will be recruited to participate in the first clinical trial to measure the potential health benefits of youth-driven racial justice activism. The five-year study, funded by a $3.8 million grant from the National Institute on Minority Health and Health Disparities, will assess whether activism can lower depression symptoms in minoritized teens, as well as alter physiological factors known to be increased with exposure to racism, such as blood pressure and markers of stress and inflammation in the blood.

13 Jul 2024

Almirall's Ebglyss recommended by NICE for NHS atopic dermatitis patients

Almirall S.A., a global biopharmaceutical company dedicated to medical dermatology, announced today that the National Institute for Health and Care Excellence (NICE) has recommended Ebglyss (lebrikizumab) for use in moderate to severe Atopic Dermatitis in the NHS England.

13 Jul 2024

WISDOM project leverages AI and data to combat chronic immune-mediated diseases in Europe

Integrating medical and research data, ensuring secure data sharing, and using advanced AI models offer immense possibilities to mitigate the impact of chronic immune-mediated diseases (CIMDs) affecting 10% of Europeans.

12 Jul 2024

Neighborhood disadvantage linked to higher expression of stress-related genes in prostate tumors

Those living in disadvantaged neighborhoods have significantly higher activity of stress-related genes, new research suggests, which could contribute to higher rates of aggressive prostate cancer in African American men.

12 Jul 2024

UQ study offers insights into how Haemophilus influenzae manipulates the immune system

Researchers from The University of Queensland have identified how a common bacterium is able to manipulate the human immune system during respiratory infections and cause persistent illness.

12 Jul 2024

Optical metabolic imaging reveals how Toxoplasma infection changes host cell metabolism

Toxoplasma gondii is a parasite responsible for toxoplasmosis, a lifelong chronic infection prevalent in about 30% of the human population.

12 Jul 2024

Study finds early, unnecessary opioid prescriptions for teen surgery

A multi-institutional study found that 1 in 6 youths fill an opioid prescription prior to surgery, and 3% of patients were still filling opioid prescriptions three to six months after surgery, indicating persistent opioid use and possible opioid dependence.

12 Jul 2024

Light-activated drugs: A revolutionary approach in neuropathic pain treatment

Light can be used to activate drugs in specific parts of the body through photopharmacology.

11 Jul 2024

Study: 40% of cancer cases in the U.S. attributable to modifiable risk factors

A new study led by researchers at the American Cancer Society (ACS) finds four in 10 cancer cases and about one-half of all cancer deaths in adults 30 years old and older in the United States (or 713,340 cancer cases and 262,120 cancer deaths in 2019) could be attributed to modifiable risk factors, including cigarette smoking, excess body weight, alcohol consumption, physical inactivity, diet, and infections.

11 Jul 2024

Lipidomics reveals health benefits of switching to plant-based fats

Switching from a diet high in saturated animal fats to one rich in plant-based unsaturated fats affects the fat composition in the blood, which in turn influences long-term disease risk.

11 Jul 2024

Researchers identify molecular processes crucial for the maturation of Group 2 innate lymphoid cells

Scientists have discovered a novel mechanism of ILC2 immune cell development which may be involved in exacerbating allergic diseases.

11 Jul 2024

‘A bottomless pit’: How out-of-pocket TMJ costs drive patients into debt

Over three decades of relentless pain, Jonna Tallant has tried about every TMJ treatment: mouthguards, six sets of braces, dental crowns and appliances, drugs, physical therapy, Botox, massage, acupuncture, chiropractic care, and surgery.

11 Jul 2024

AI model accurately estimates pulmonary function from chest x-rays

Chest x-rays using a deep learning-based model.

11 Jul 2024

Liver's defense mechanism hinders immunity in chronic hepatitis B, study reveals

In chronic hepatitis B, the liver contains immune cells that could destroy hepatitis B virus infected cells but are inactive. A team from the Technical University of Munich (TUM) has discovered that cells blood vessels in the liver start a "sleep timer" that switches off immune cells. Targeting this mechanism could be a starting point for immunotherapies.

11 Jul 2024

Existing drug shows promise for treating common liver disease

The University of Barcelona has led a study that suggests using the drug known as pemafibrate to treat liver disease associated with metabolic disorders, the most common liver pathology in the world, which affects one in four people. The drug has long been marketed in Japan for another use: improving blood lipid levels in patients with hyperlipidaemia, a common condition in diabetics. Now, however, it could help address this serious liver disease, which still has no specific treatment.

11 Jul 2024

Chronic News and Research

New brain targets for GLP1-based obesity drugs may reduce weight without nausea

Study reveals how inflammation weakens muscles during illness

Testing the effectiveness of youth activism as a mental health intervention

Almirall's Ebglyss recommended by NICE for NHS atopic dermatitis patients

WISDOM project leverages AI and data to combat chronic immune-mediated diseases in Europe

Neighborhood disadvantage linked to higher expression of stress-related genes in prostate tumors

UQ study offers insights into how Haemophilus influenzae manipulates the immune system

Optical metabolic imaging reveals how Toxoplasma infection changes host cell metabolism

Study finds early, unnecessary opioid prescriptions for teen surgery

Light-activated drugs: A revolutionary approach in neuropathic pain treatment

Study: 40% of cancer cases in the U.S. attributable to modifiable risk factors

Lipidomics reveals health benefits of switching to plant-based fats

Researchers identify molecular processes crucial for the maturation of Group 2 innate lymphoid cells

‘A bottomless pit’: How out-of-pocket TMJ costs drive patients into debt

AI model accurately estimates pulmonary function from chest x-rays

Liver's defense mechanism hinders immunity in chronic hepatitis B, study reveals

Existing drug shows promise for treating common liver disease

Four years non-diabetic status after impaired glucose tolerance diagnosis cuts cardiovascular risks

Aging aggravates liver fibrosis in Down Syndrome, new study finds

Repurposing pemafibrate to treat liver disease associated with metabolic disorders

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

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