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Novel nanoscale molecular slingshot could ‘shoot’ and deliver drugs at precise disease locations

An international team of researchers from the University of Rome Tor Vergata and the University of Montreal has reported, in a paper published this week in Nature Communications, the design and synthesis of a nanoscale molecular slingshot made of DNA that is 20,000 times smaller than a human hair.

9 May 2017

Texas A&M researchers aim to develop one drug that treats pain, memory and nicotine addiction

Although pain, memory and nicotine addiction may not seem to be related, they actually share a common player: the nicotinic acetylcholine receptors.

5 May 2017

Recurrence of HPV-negative HNSCC after radiation therapy linked to high tumor levels of PD-L1 protein

Recurrence of head and neck squamous cell carcinoma (HNSCC) negative for human papillomavirus (HPV) following radiation therapy was associated with high tumor levels of the protein PD-L1.

5 May 2017

Discovery of signaling pathway offers new functional framework for treating schizophrenia

Neuroscientists at Tufts University School of Medicine have discovered a new signaling pathway that directly connects two major receptors in the brain associated with learning and memory – the N-methyl-D-aspartate receptor (NMDAR) and the alpha 7 nicotinic acetylcholine receptor (a7nAChR) – which has significance for current efforts to develop drugs to treat schizophrenia.

4 May 2017

IDIBELL researchers reveal role of endoplasmic reticulum in cell death process due to starvation

Researchers from the Cell death group of the Bellvitge Biomedical Research Institute, led by Dr. Cristina Muñoz-Pinedo, have characterized the cell death process due to starvation, in which the endoplasmic reticulum plays a leading role.

3 May 2017

EKF Diagnostics expands the distribution of its Procalcitonin LiquiColor® Test into Eastern Europe, Middle East and APAC regions

EKF, announces that it is expanding the distribution of its Procalcitonin LiquiColor Test into Eastern Europe, Middle East and APAC regions.

From EKF Diagnostics 3 May 2017

Myriad and Clovis ink deal on FDA-approved BRACAnalysis CDx test to identify patients with germline BRCA mutations for rucaparib treatment

Myriad Genetics, Inc. and Clovis Oncology, Inc. have announced a companion diagnostic collaboration to support a post-marketing regulatory commitment related to Clovis’ PARP inhibitor, Rubraca. Financial terms of the deal were not disclosed.

3 May 2017

Glycated CD59 identified as novel biomarker for screening and diagnosis of gestational diabetes

Mellitus, LLC today reported the publication of results from a prospective, investigator-initiated study conducted at Brigham and Women's Hospital demonstrating the potential clinical utility of glycated CD59 (GCD59) as a novel biomarker for the screening and diagnosis of gestational diabetes mellitus.

28 Apr 2017

Improvements to animal testing protocols could yield more useful clinical results

The use of animals in biomedical research has long been the focus of campaigns by animal rights activists. Two leading scientists writing in the European Journal of Internal Medicine give their expert view of the importance of animal testing to medical progress and present ways it could be further improved to yield more useful clinical results.

27 Apr 2017

Study finds link between fertility treatments and pediatric tumors

Ben-Gurion University of the Negev researchers have found that babies born from mothers who underwent fertility treatments are at increased risk of developing many types of pediatric cancers and tumors (neoplasms).

25 Apr 2017

Scientists use stem cells to identify underlying cellular defects that cause Angelman syndrome

Researchers at UConn Health used stem cells derived from patients with Angelman syndrome to identify the underlying cellular defects that cause the rare neurogenetic disorder, an important step in the ongoing search for potential treatments for Angelman and a possible cure.

25 Apr 2017

New model for toxicity risk assessment could reduce reliance on animal testing

Traditional toxicological investigations performed on animals (in vivo) are expensive, time-consuming and may cause animal suffering.

24 Apr 2017

Researchers develop promising blood substitute for transfusions

Blood transfusions can save the lives of patients who have suffered major blood loss, but hospitals don't always have enough or the right type on hand. In search of a solution, researchers have developed a promising substitute using blood's oxygen-carrying component, hemoglobin.

19 Apr 2017

Strawberry extract can inhibit spread of breast cancer cells, mice study shows

A study by European and Latin American researchers has shown that strawberry extract can inhibit the spread of laboratory-grown breast cancer cells, even when they are inoculated in female mice to induce tumours.

19 Apr 2017

Cytokine plays critical role in driving immune cells to promote or suppress inflammatory bowel disease

A certain cytokine, or small protein that helps cells communicate during immune responses, can control whether immune cells promote or suppress inflammatory bowel disease, a finding that could lead to new treatments, according to a study led by Georgia State University.

18 Apr 2017

Researchers correct Duchenne muscular dystrophy using gene-editing alternative

Using the new gene-editing enzyme CRISPR-Cpf1, researchers at UT Southwestern Medical Center have successfully corrected Duchenne muscular dystrophy in human cells and mice in the lab.

13 Apr 2017

Study shows um-PEA as safe and efficacious adjuvant treatment for advanced PD patients

Parkinson disease (PD) is a long-term degenerative disorder of the central nervous system that mainly affects the motor system.

12 Apr 2017

Researchers uncover mechanism that leads to disorders in pancreatic development, infant diabetes

Researchers at the University of Helsinki, Finland, have uncovered a mechanism through which a mutation in the STAT3 gene leads to a disorder in the development of the pancreas and to infant diabetes.

11 Apr 2017

New nanowire technology may serve as platform to screen drugs for neurological diseases

A team led by engineers at the University of California San Diego has developed nanowires that can record the electrical activity of neurons in fine detail.