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Histone H1 phosphorylation involved in control of ribosomal RNA gene transcription

A protein that helps pack DNA into the cell nucleus has an important role in regulating gene activity, scientists report. The researchers found that the protein, histone H1, also takes part in the formation of ribosomes, the cellular workbenches on which all proteins are made.

2 Jul 2010

Plant extract effective against ulcerative colitis in mice

A South Dakota State University scientist's research shows an extract made from a food plant in the Brassica family was effective in alleviating signs of ulcerative colitis, an inflammatory bowel condition, in mice.

2 Jul 2010

DNA damage caused by UVA radiation leads to melanoma

A new study by researchers at NYU School of Medicine found that UVA radiation damages the DNA in human melanocyte cells, causing mutations that can lead to melanoma. Melanocytes, which contain a substance called melanin that darkens the skin to protect it from the ultraviolet rays of the sun, are more vulnerable to UVA radiation than normal skin cells because they are unable to repair themselves as efficiently.

2 Jul 2010

Research shows promising targeted therapies for type 2 diabetes patients

Named for the furballs whose astonishing fecundity made them stars in early Star Trek episodes, the tribbles protein, first identified in fruit flies, aids in regulating many cell processes in humans. Joslin Diabetes Center researchers now have identified mechanisms triggered by a variant of the tribbles gene that cause trouble in insulin-producing pancreatic beta cells—and that offer a promising target for therapies for people with type 2 diabetes, even if they don't carry that gene variant.

2 Jul 2010

Research findings suggest new treatment approach to improve corneal transplants

Although it is already one of medicine's most successful transplant procedures, doctors continue to seek ways to improve corneal transplants. Now, for the first time, a team of German and British researchers have confirmed that failure and rejection of transplanted corneas are more likely in patients whose eyes exhibit abnormal vessel growth, called corneal neovascularization, prior to surgery.

1 Jul 2010

Ronin, Hcf-1 bind together to control gene program that stimulates growth of stem cells

Ronin, crucial to the self-renewal of embryonic stem cells, and a co-regulator called Hcf-1, binds to a small strand of DNA called a hyperconserved enhancer element to control a gene "program" that stimulates growth of the stem cells and may even play a role in cancer, said a group of researchers led by Baylor College of Medicine in a current report in the journal Genes and Development.

1 Jul 2010

Florida Biomedical Research Program awards $2M in grants to Scripps Research Institute scientists

The Florida Biomedical Research Program has awarded $2 million in biomedical research grants to three scientists from the Florida campus of The Scripps Research Institute.

1 Jul 2010

Gen-Probe's APTIMA Trichomonas assay receives European CE mark

Gen-Probe Incorporated announced today that it has received a European CE mark for its APTIMA® assay for Trichomonas vaginalis, a common parasitic sexually transmitted disease.

1 Jul 2010

Oxygen can combat wrinkle formation by reducing UVB damage

It's no secret that UVB radiation from the sun causes wrinkles. However, a Japanese study published in the American Journal of Physiology—Regulatory, Integrative and Comparative Physiology (http://ajpregu.physiology.org/) indicates that oxygen may help combat the formation of wrinkles by lessening tissue damage done by UVB rays.

30 Jun 2010

Greenway to provide physician's infrastructure solutions to St. Cloud Medical Group

Greenway Medical Technologies, Inc. is partnering with St. Cloud Medical Group to provide its single-database electronic health record (EHR), practice management and interoperability solution PrimeSuite®, online portal PrimePatient® and remote clinic PrimeMobile™ to St. Cloud's primary care, urgent care, occupational health, surgical, pediatrics, pain management, and OB/GYN services.

28 Jun 2010

Engineered allosteric regulation provides precise control of kinase activity in living cells

Cancer occurs when human cells move and multiply inappropriately. Within cells, a process called phosphorylation serves as an on/off switch for a number of cellular processes that can be involved in cancer, including metabolism, transcription, configuration, movement, cell death and differentiation. This process is controlled by a group of enzymes called protein kinases that - working together and separately - modify the structure of proteins, changing them and allowing them to control cellular processes.

28 Jun 2010

TLR4 may provide new strategy for treating patients with PDAC: Study

Pancreatic ductal adenocarcinoma is a highly malignant digestive tumor with a very poor prognosis. Hypoxia-inducible transcription factor-1α is involved in malignant progression in many solid tumors, including PDAC, upregulation of HIF-1α accelerates PDAC progression, but the exact regulatory mechanisms of HIF-1αin PDAC has not been unequivocally addressed.

28 Jun 2010

New book provides comprehensive review of the functions of p53 family

The p53 tumor suppressor gene, the "guardian of the genome," protects cells against genotoxic stress but is mutated in many cancers. It encodes one of a family of proteins that regulate cell proliferation, differentiation, senescence, and cell death. Mutations in p53 allow cells to escape normal growth controls and thereby contribute to tumor malignancy.

24 Jun 2010

Beneficial effects of LifeVantage's Protandim on DMD mouse model published in Journal of Dietary Supplements

LifeVantage Corporation, the maker of Protandim®, a patented, science-based solution to oxidative stress, announced today that a peer-reviewed manuscript was published in the Journal of Dietary Supplements examining the beneficial effects of Protandim® on a mouse model of Duchenne Muscular Dystrophy (DMD), an X-linked inherited disease affecting one in 3,500 males.

22 Jun 2010

Electron cryomicroscopy helps observe molecules in hydrated state close to natural state

Gene expression takes place in two stages: the transcription of DNA to RNA by an enzyme called RNA polymerase, , followed by the translation of this RNA into proteins, whose behaviour affects the characteristics of each individual.

21 Jun 2010

iMedX acquires assets of PRN

iMedX Inc., a leading healthcare software and services company, announced today that it has acquired the assets of PRN Medical Management, LLC, a medical transcription company serving medical clinics for over 18 years, primarily in Maryland, Washington DC, and Virginia. With the acquisition of PRN, iMedX expands its base in the Washington DC metro area and beyond. PRN's employees in India will be absorbed by iMedX's subsidiary Worldtech.

19 Jun 2010

Gladstone Institute researcher to receive Kyoto Prize in Advanced Technology

The non-profit Inamori Foundation (President: Dr. Kazuo Inamori) today announced that Dr. Shinya Yamanaka will receive its 26th annual Kyoto Prize in Advanced Technology, which for 2010 focuses on the fields of Biotechnology and Medical Technology. Dr. Yamanaka, 47, will receive the award for his pioneering work in developing a technology to generate pluripotent stem cells that does not require the use of human embryos.

18 Jun 2010

Kun Run Biotechnology obtains China SFDA manufacturing approval for Entecavir

Kun Run Biotechnology, Inc., a leading bio-pharmaceutical company in China focusing on manufacturing and sales of peptide-based and small molecule drugs, today announced that they have obtained the manufacturing approval for Entecavir from the China State Food and Drug Administration (SFDA).

17 Jun 2010

PHT, Entra Health partner to provide integrated data monitoring technology for clinical trials in diabetes

PHT Corporation, the leading provider of electronic patient reported outcome (ePRO) solutions today announced a strategic partnership with Entra Health Systems, an international applied healthcare technology company. Together PHT and Entra Health will provide integrated data monitoring technology for the management of clinical trials for the treatment of diabetes and in trials where blood glucose management plays a critical role in the investigation.

10 Jun 2010

Hooper Holmes launches iParamed Expedite for insurance applications

Hooper Holmes today introduced iParamed Expedite, a new service that cuts costs and improves accuracy for insurance applications. It is six to seven days faster than current approaches and has been designed to quickly and accurately qualify applicants for life, long-term care, health and Medicare Supplement insurance policies.

9 Jun 2010

Transcription News and Research

Histone H1 phosphorylation involved in control of ribosomal RNA gene transcription

Plant extract effective against ulcerative colitis in mice

DNA damage caused by UVA radiation leads to melanoma

Research shows promising targeted therapies for type 2 diabetes patients

Research findings suggest new treatment approach to improve corneal transplants

Ronin, Hcf-1 bind together to control gene program that stimulates growth of stem cells

Florida Biomedical Research Program awards $2M in grants to Scripps Research Institute scientists

Gen-Probe's APTIMA Trichomonas assay receives European CE mark

Oxygen can combat wrinkle formation by reducing UVB damage

Greenway to provide physician's infrastructure solutions to St. Cloud Medical Group

Engineered allosteric regulation provides precise control of kinase activity in living cells

TLR4 may provide new strategy for treating patients with PDAC: Study

New book provides comprehensive review of the functions of p53 family

Beneficial effects of LifeVantage's Protandim on DMD mouse model published in Journal of Dietary Supplements

Electron cryomicroscopy helps observe molecules in hydrated state close to natural state

iMedX acquires assets of PRN

Gladstone Institute researcher to receive Kyoto Prize in Advanced Technology

Kun Run Biotechnology obtains China SFDA manufacturing approval for Entecavir

PHT, Entra Health partner to provide integrated data monitoring technology for clinical trials in diabetes

Hooper Holmes launches iParamed Expedite for insurance applications

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

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