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Researchers track adipose tissue-derived stromal cells after transplantation

Using mesenchymal stromal cells derived from adipose (fat) tissues, genetically modified to express a bioluminescent marker, researchers in Italy have tracked cells after transplantation. The cells were followed from their injection into the spleen of mice modeling liver disease, to their characterization as "hepatic precursors," and to their subsequent migration through the spleen before engrafting at regenerating sites in the liver by bioluminescent imaging.

21 Dec 2012

New work on Akt's role in cancer stem cell biology

The protein kinase Akt is a key regulator of cell growth, proliferation, metabolism, survival, and death. New work on Akt's role in cancer stem cell biology from the lab of senior author Honglin Zhou, MD, PhD and Weihua Li, co-first author, both from the Center for Resuscitation Sciences, Department of Emergency Medicine, Perelman School of Medicine, University of Pennsylvania, and Xiaowei Xu, Department of Pathology and Laboratory Medicine, appears in Molecular Cell.

21 Dec 2012

Study examines five varieties of cells after transplantation in the CNS

When different types of cells are transplanted with the intent of having them aid in repairing central nervous system (CNS) trauma, what is the fate and function of those cells? A Belgian research team carried out research aimed at answering this question by determining how five varieties of cells - neural stem cells, mouse embryonic fibroblasts, dendritic cells, bone marrow mononuclear cells (BMMNCs) and splenocytes - functioned and survived after transplantation in the CNS.

21 Dec 2012

Study shows dramatic underuse of basic medical therapy

Patients who quit smoking and took an aspirin and statin before undergoing treatment for blocked leg arteries were less likely to suffer a complication six months later, according to new research led by the University of Michigan Cardiovascular Center.

21 Dec 2012

Two recent experimental treatments improve visual function in mouse models of retinitis pigmentosa

Two recent experimental treatments - one involving skin-derived induced pluripotent stem (iPS) cell grafts, the other gene therapy - have been shown to produce long-term improvement in visual function in mouse models of retinitis pigmentosa (RP), according to the Columbia University Medical Center (CUMC) scientists who led the studies. At present, there is no cure for RP, the most common form of inherited blindness.

20 Dec 2012

Viewpoints: Could expanding mental health services curb gun violence?; Opinions on other aspects of health law

President Obama said he would use whatever powers his office holds to address this violence. ... Currently, nearly half of all gun sales in the U.S. are conducted without a background check. Criminals, the mentally ill, minors and domestic abusers are all prohibited from purchasing guns, but they all can do so as easily as attending a gun show or going online.

20 Dec 2012

Echo Therapeutics prices underwritten public offering of 3,200,000 shares of common stock

Echo Therapeutics, Inc., a company developing its needle-free Symphony tCGM System as a non-invasive, wireless, transdermal continuous glucose monitoring system, today announced the pricing of a previously announced underwritten public offering of 3,200,000 shares of its common stock, offered at a price to the public of $0.95 per share.

20 Dec 2012

Study finds new signaling pathway involved in development of chronic inflammation of brain cells

The number of Alzheimer's patients will continue to dramatically increase in the next several decades. Various teams of researchers worldwide are feverishly investigating precisely how the illness develops. A

20 Dec 2012

Maternal vitamin D deficiency could cause low birth weight

Women deficient in vitamin D early in their pregnancies are more likely to deliver babies with lower birth weights, University of Pittsburgh Graduate School of Public Health research reveals.

20 Dec 2012

Proteins detected in urine may enable diagnosis of Kawasaki disease

A set of proteins detected in urine by researchers at Boston Children's Hospital may prove to be the first biomarkers for Kawasaki disease, an uncommon but increasingly prevalent disease which causes inflammation of blood vessels that can lead to enlarged coronary arteries and even heart attacks in some children.

20 Dec 2012

Roundup: Calif. Report sets 10-year health goals; Conn. hospitals plead to stop cuts; Colo. lawmaker wants state universal health care on ballot

With the state facing rising medical costs and increasing rates of chronic disease, California health leaders issued a report Wednesday setting specific health targets to meet by 2022. The state's goals include reducing smoking rates, increasing vaccinations among children and improving depression screening and treatment. The report also describes ways to improve end-of-life care, by expanding palliative care at hospitals and hospice programs at home.

20 Dec 2012

Bariatric surgery rates dropping in adolescents

Rates of bariatric surgery in adolescents have plateaued since 2003, despite childhood obesity being on the increase, suggest US study findings.

20 Dec 2012

French method successful for clubfoot

Researchers have demonstrated the efficacy of the “French” functional method for correcting congenital idiopathic clubfoot, with the majority of patients achieving a good result, often without surgery.

20 Dec 2012

Slushy spares kidney during partial nephrectomy

US researchers report the success and feasibility of a novel method of carrying out partial nephrectomy in kidney patients, using minimally invasive surgery.

20 Dec 2012

Disparities in HIV care in Ontario

Researchers have found significant disparities in hospital admission rates for certain groups of individuals living with HIV in Ontario, Canada.

20 Dec 2012

Bipolar subtypes show neurobiologic differences

Results from a Taiwanese study show that there are significant neurobiologic differences between patients with bipolar I and II disorder.

20 Dec 2012

Primary opponensplasty superior to osteosynthesis

Primary opponensplasty in toe transfers provides active restoration of thumb opposition and significantly better restoration of tripod pinch than does static opposition with osteosynthesis , research suggests.

20 Dec 2012

V-chip could allow health care providers to do 50 different tests in one go

A new device about the size of a business card could allow health care providers to test for insulin and other blood proteins, cholesterol, and even signs of viral or bacterial infection all at the same time—with one drop of blood. Preliminary tests of the V-chip, created by scientists at The Methodist Hospital Research Institute and MD Anderson Cancer Center, were published last night by Nature Communications.

20 Dec 2012

Newtown shooting spotlights gaps in mental health care

The elementary school massacre prompts an examination of mental health care policies and access to guns by the mentally ill.

20 Dec 2012

Study focuses on hormone-sensitive breast tumours

Gene expression in breast cancer provides valuable biological information for better determining the diagnosis, treatment, risk of relapse and survival rate. However, the most common form of characterizing breast cancer is by histopathological techniques. This study, headed by Dr Aleix Prat, Head of the Translational Genomics Group at the Vall d'Hebron Institute of Oncology (VHIO) and an oncologist at the Breast Cancer Unit of the Vall d´Hebron University Hospital, focused on hormone-sensitive breast tumours known as luminals.

20 Dec 2012