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'Mismatch repair' genetic defects drive cancer patient's response to immunotherapy drugs

In an expanded, three-year clinical trial of 86 patients with colorectal and 11 other kinds of cancer that have so-called 'mismatch repair' genetic defects, scientists at Johns Hopkins Medicine and its Bloomberg~Kimmel Institute for Cancer Immunotherapy have found that half of the patients respond to an immunotherapy drug called pembrolizumab.

9 Jun 2017

Researchers uncover molecule in newborn hearts that appears to control renewal process

Heart disease remains the leading cause of death worldwide, yet the few available treatments are still mostly unsuccessful once the heart tissue has suffered damage.

9 Jun 2017

Joslin Diabetes Center researchers establish CCTD to develop and translate cell-based interventions

Researchers and clinicians at Joslin Diabetes Center have established a Center for Cell-Based Therapy for Diabetes, the goal of which is to lead the development and translation of cell-based interventions to treat and cure diabetes and its complications.

9 Jun 2017

UAB emergency medicine physician offers tips to deal with snakebite

Allison Davis never saw the snake. The Mountain Brook, Alabama, elementary school teacher was pulling weeds from a planter on her deck when she felt a sharp stab of pain in her left hand.

9 Jun 2017

Adult male farmers in Malaysia more likely to contract 'monkey malaria'

Adult male farmers in Malaysia are more than twice as likely to contract Plasmodium knowlesi malaria - an infection usually found only in monkeys - than other people in their communities, according to a new study published in The Lancet Planetary Health.

9 Jun 2017

Radiation therapy critical to treating brain tumors, but linked to significant adverse effects

Radiation therapy using high-energy particles, like x-rays or electron beams, is a common and critical component in successfully treating patients with brain tumors, but it is also associated with significant adverse effects, such as neuronal loss in adjacent healthy tissues.

9 Jun 2017

Study provides new insight into cells that rejuvenate the brain

Alzheimer's disease is a neurodegenerative disease manifested by various neuronal pathological processes and a significant decline in brain function.

9 Jun 2017

New research design offers way to assess safety of approved drugs

As the pace of drug approvals accelerates and the U.S. Food and Drug Administration faces potential budget cuts, a new research design from Perelman School of Medicine scientists offers a new way to successfully assess safety of newly approved drugs, as well as drugs that have been on the market for a long time and have had a marked rise in their use.

9 Jun 2017

IUPUI researchers find differing risks for binge drinking based on race, income and age

A new study led by Indiana University-Purdue University Indianapolis assistant professor of psychology Tamika Zapolski has found differing risks for binge drinking based on race, income and age.

9 Jun 2017

New diagnostic test uses machine learning to accurately detect aggressive prostate cancer

A new diagnostic developed by Alberta scientists will allow men to bypass painful biopsies to test for aggressive prostate cancer.

9 Jun 2017

Researchers study space-exposed worms to improve understanding of regenerative health

Flatworms that spent five weeks aboard the International Space Station are helping researchers led by Tufts University scientists to study how an absence of normal gravity and geomagnetic fields can have anatomical, behavioral, and bacteriological consequences, according to a paper to be published June 13 in Regeneration.

9 Jun 2017

Cesarean patients prescribed more opioid pain medications than needed, study shows

Most women who undergo a cesarean childbirth are prescribed more opioid (narcotic) pain medications than needed upon release from the hospital, a Vanderbilt University Medical Center study shows.

9 Jun 2017

Removal of senescent cells could delay onset of age-related pathologies

A recent study, led by an international team of researchers confirms that targeted removal of senescent cells (SnCs), accumulated in many vertebrate tissues as we age, contribute significantly in delaying the onset of age-related pathologies.

9 Jun 2017

New discovery provides explanation for preterm infants' susceptibility to lung diseases later in life

Mice born into an oxygen-rich environment respond worse to the flu once fully grown due to an absence of certain lung cells, a discovery that provides a potential explanation for preterm infants' added susceptibility to influenza and other lung diseases later in their lives, according to new research from the University of Rochester Medical Center

9 Jun 2017

UAMS scientists show potential of world's smallest laser to kill single cancer cells

A University of Arkansas for Medical Sciences research team led by Vladimir Zharov, Ph.D., D.Sc., has demonstrated the ability to kill single cancer cells using the world's smallest laser.

9 Jun 2017

Smarter algorithms could lead to greater understanding of the brain's true complexity

The human brain naturally makes its best guess when making a decision, and studying those guesses can be very revealing about the brain's inner workings.

9 Jun 2017

Delayed food introduction may increase likelihood of allergy in later childhood

Delaying the introduction of potentially allergenic foods until after a baby's first year may increase the likelihood of a food allergy later on, according to new findings from the Canadian Healthy Infant Longitudinal Development Study.

8 Jun 2017

Researchers who study HED identify mechanism that may be disrupted in male pattern baldness

It is almost axiomatic in medicine that the study of rare disorders informs the understanding of more common, widespread ailments.

8 Jun 2017

Researchers examine link between income level and cancer diagnosis

Do wealthier people receive too much medical care? In a Perspective article recently published in the New England Journal of Medicine, H. Gilbert Welch, MD, and Elliott Fisher, MD, of The Dartmouth Institute for Health Policy and Clinical Practice examine the association between income level and cancer diagnosis.

8 Jun 2017

Cannabis use during adolescence linked to greater risk of illegal substance abuse in early adulthood

According to the study published online in the Journal of Epidemiology & Community Health, regular and occasional use of cannabis as an adolescent is linked with a greater risk of other illicit drug consumption in early adulthood. The study by Bristol's Population Health Science Institute also found that cannabis use was connected with harmful drinking and smoking. One in five adolescents are at a risk of tobacco dependency, harmful alcohol consumption, and illicit drug use.

8 Jun 2017

Medicine News and Research

'Mismatch repair' genetic defects drive cancer patient's response to immunotherapy drugs

Researchers uncover molecule in newborn hearts that appears to control renewal process

Joslin Diabetes Center researchers establish CCTD to develop and translate cell-based interventions

UAB emergency medicine physician offers tips to deal with snakebite

Adult male farmers in Malaysia more likely to contract 'monkey malaria'

Radiation therapy critical to treating brain tumors, but linked to significant adverse effects

Study provides new insight into cells that rejuvenate the brain

New research design offers way to assess safety of approved drugs

IUPUI researchers find differing risks for binge drinking based on race, income and age

New diagnostic test uses machine learning to accurately detect aggressive prostate cancer

Researchers study space-exposed worms to improve understanding of regenerative health

Cesarean patients prescribed more opioid pain medications than needed, study shows

Removal of senescent cells could delay onset of age-related pathologies

New discovery provides explanation for preterm infants' susceptibility to lung diseases later in life

UAMS scientists show potential of world's smallest laser to kill single cancer cells

Smarter algorithms could lead to greater understanding of the brain's true complexity

Delayed food introduction may increase likelihood of allergy in later childhood

Researchers who study HED identify mechanism that may be disrupted in male pattern baldness

Researchers examine link between income level and cancer diagnosis

Cannabis use during adolescence linked to greater risk of illegal substance abuse in early adulthood

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