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Researchers find how collagen production helps drive tumour growth, development

Cancer Research UK scientists have revealed how the dense tissue that surrounds tumours helps drive tumour growth and development, according to research published in the journal Cancer Cell.

14 Jun 2011

Astellas, Ambit Biosciences announce interim results from AC220 Phase 2 trial against AML

Ambit Biosciences Corporation and Astellas Pharma Inc. announced today results from a planned interim analysis in an ongoing Phase 2 study evaluating AC220, a potent and selective FLT3 inhibitor.

14 Jun 2011

Smoking ban in NSW prison

In a new directive, prisoners at the Lithgow jail in central western New South Wales will be banned from smoking in their cells as part of a six-month trial to begin next year.

13 Jun 2011

Oncogene Aurora A may contribute to polycystic kidney disease

The Aurora A kinase may contribute to polycystic kidney disease (PKD) by inactivating a key calcium channel in kidney cells, according to a study in the June 13 issue of The Journal of Cell Biology.

13 Jun 2011

Positive preliminary results from CytRx bafetinib Phase 2 trial for relapsed B-cell chronic lymphocytic leukemia

CytRx Corporation, a biopharmaceutical company specializing in oncology, today announced that preliminary results from its ENABLE Phase 2 proof-of-concept trial demonstrated that bafetinib, the Company's Bcr-Abl, Lyn and Fyn kinase inhibitor, was clinically active in a group of patients with relapsed or refractory B-cell chronic lymphocytic leukemia (B-CLL) who have failed several other treatments for their cancer.

13 Jun 2011

Study reveals positive impact of Soliris on long-term outcomes in PNH patients

Alexion Pharmaceuticals, Inc. today announced the presentation of research that provides further insight into the clinical consequences of paroxysmal nocturnal hemoglobinuria (PNH), and positive impact of Soliris® (eculizumab) therapy on long-term outcomes.

13 Jun 2011

CEL-SCI initiates Multikine Phase III clinical trial for head and neck cancer in Hungary

CEL-SCI Corporation announced today that it has commenced its Phase III clinical trial for Multikine®, the Company's flagship immunotherapy, at the National Institute of Oncology in Budapest, Hungary. Enrollment is expected to start soon in this center. The study is already ongoing at twelve clinical sites in the United States, Canada, Poland and India.

13 Jun 2011

GORE SEAMGUARD Bioabsorbable Staple Line Reinforcement receives Heath Canada approval

W. L. Gore & Associates, Inc. today announced at the American Society for Metabolic and Bariatric Surgery Meeting that it has received approval from Health Canada for GORE® SEAMGUARD® Bioabsorbable Staple Line Reinforcement. The device is specifically engineered to reduce the incidence of perioperative leaks and bleeding in a variety of open and minimally invasive surgeries.

13 Jun 2011

Circassia announces ToleroMune vaccine phase II trial results against cat allergy

Circassia Ltd, a specialty biopharmaceutical company focused on allergy, today announced the results of a phase II clinical trial showing that patients who received four doses of its ToleroMune cat allergy vaccine over a 12-week period maintained a statistically significant reduction in symptoms one year later.

13 Jun 2011

UC Davis, Jackson Laboratory and NCI partner for human clinical trials on cancer

About nine out of 10 new cancer drugs successfully clear preclinical development hurdles, but then they fail in human clinical testing. A new partnership facilitated by SAIC-Frederick Inc. aims to help change that outcome.

13 Jun 2011

MCMs mediate crosstalk between cell division machinery and oxygen-sensing protein

13 Jun 2011

Scientists identify potential target for reversing deadly blood infection sepsis

By digging a little deeper, researchers may have found a potential target for reversing the deadly blood infection sepsis.

13 Jun 2011

Human adult and embryonic stem cell research can benefit medical science, researchers say

New research says studying both adult and embryonic stem cells can benefit medical science, but banning the study of either type could harm studies of the other.

13 Jun 2011

NYU Langone webinar discusses advances in the treatment of RA

Steven Abramson, MD, professor of medicine and director of the rheumatology division at NYU Langone Medical Center, hosted a webinar with colleagues from the medical center for rheumatoid arthritis community bloggers - bringing together, bench, bedside and the blogosphere to discuss advances in the investigation, care, and treatment of RA.

13 Jun 2011

Incyte announces additional results from ruxolitinib Phase III trial on myelofibrosis

Incyte Corporation announced today additional symptom improvement and quality of life (QoL) results from COMFORT-I, a randomized, double-blinded, placebo-controlled Phase III trial of Incyte's JAK1 and JAK2 inhibitor, ruxolitinib, in patients with myelofibrosis (MF).

13 Jun 2011

Scientists pioneer way to find more chromosomal aberrations in tumors

Washington University Pediatric Cancer Genome Project scientists pioneer way to find more chromosomal aberrations in tumors; results likely to advance understanding of cancer.

13 Jun 2011

Kurma, CRT launch BliNK Therapeutics to generate monoclonal antibodies

Cancer Research Technology, the commercial arm of Cancer Research UK, and Paris-based venture capital firm, Kurma Life Sciences Partners (Kurma), have launched a spin-out company, BliNK Therapeutics Ltd, to generate monoclonal antibodies using a novel platform.

13 Jun 2011

Seattle Genetics, Millennium ADCETRIS phase I trial data on Hodgkin lymphoma presented at EHA

Millennium: The Takeda Oncology Company, a wholly owned subsidiary of Takeda Pharmaceutical Company Limited and Seattle Genetics, Inc., announced today that data on ADCETRIS (brentuximab vedotin) in relapsed or refractory Hodgkin lymphoma patients were featured in an oral presentation at the 16th Congress of the European Hematology Association (EHA) in London.

13 Jun 2011

Final data from Alexion's Soliris Phase 2 studies on aHUS presented at EHA 2011

Alexion Pharmaceuticals, Inc. today announced the presentation of final data from the two Phase 2 studies of Soliris as a treatment for patients with atypical hemolytic uremic syndrome.

13 Jun 2011

Cell division linked to oxygen levels: Johns Hopkins research

Cells grow abundant when oxygen is available, and generally stop when it is scarce. Although this seems straightforward, no direct link ever has been established between the cellular machinery that senses oxygen and that which controls cell division. Now, in the June 10 issue of Molecular Cell, researchers at Johns Hopkins report that the MCM proteins, which promote cell division, also directly control the oxygen-sensing HIF-1 protein.

12 Jun 2011

Cell News and Research

Researchers find how collagen production helps drive tumour growth, development

Astellas, Ambit Biosciences announce interim results from AC220 Phase 2 trial against AML

Smoking ban in NSW prison

Oncogene Aurora A may contribute to polycystic kidney disease

Positive preliminary results from CytRx bafetinib Phase 2 trial for relapsed B-cell chronic lymphocytic leukemia

Study reveals positive impact of Soliris on long-term outcomes in PNH patients

CEL-SCI initiates Multikine Phase III clinical trial for head and neck cancer in Hungary

GORE SEAMGUARD Bioabsorbable Staple Line Reinforcement receives Heath Canada approval

Circassia announces ToleroMune vaccine phase II trial results against cat allergy

UC Davis, Jackson Laboratory and NCI partner for human clinical trials on cancer

MCMs mediate crosstalk between cell division machinery and oxygen-sensing protein

Scientists identify potential target for reversing deadly blood infection sepsis

Human adult and embryonic stem cell research can benefit medical science, researchers say

NYU Langone webinar discusses advances in the treatment of RA

Incyte announces additional results from ruxolitinib Phase III trial on myelofibrosis

Scientists pioneer way to find more chromosomal aberrations in tumors

Kurma, CRT launch BliNK Therapeutics to generate monoclonal antibodies

Seattle Genetics, Millennium ADCETRIS phase I trial data on Hodgkin lymphoma presented at EHA

Final data from Alexion's Soliris Phase 2 studies on aHUS presented at EHA 2011

Cell division linked to oxygen levels: Johns Hopkins research

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