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Brazilian researchers develop hES cell line for therapeutic transplantation

Brazilian researchers, reporting in the current issue of Cell Transplantation, discovered difficulties in establishing a genetically diverse line of human embryonic stem cells to serve the therapeutic stem cell transplantation needs of the diverse ethnic and genetic Brazilian population.

3 May 2011

Techne acquires Tocris Holdings

Techne Corporation announced today that it has acquired 100% ownership of Tocris Holdings Limited and subsidiaries, a leading supplier of reagents for non-clinical life science research.

3 May 2011

RBC transfusion linked to improved survival after intracerebral hemorrhage

In patients with intracerebral hemorrhage —a type of stroke caused by bleeding inside the brain—transfusion with red blood cells may improve the chances of survival, reports a study in the May issue of Neurosurgery, official journal of the Congress of Neurological Surgeons.

3 May 2011

Lopinavir can combat HPV-related cervical cancer

A widely used HIV drug could be used to prevent cervical cancer caused by infection with the human papilloma virus, say scientists.

3 May 2011

Busy brain cells can both contribute to and prevent Alzheimer's

Higher levels of cell chatter boost amyloid beta in the brain regions that Alzheimer's hits first, researchers at Washington University School of Medicine in St. Louis report. Amyloid beta is the main ingredient of the plaque lesions that are a hallmark of Alzheimer's.

3 May 2011

Tips on how to stay safe and heal emotionally after tornado attack

Although the threat of another tornado is gone for now, other potential dangers lurk in the storm's aftermath, said several University of Alabama at Birmingham experts. They recently offered tips on how to stay safe and heal emotionally in the days after the devastating April 27 storm.

3 May 2011

CTI to re-submit pixantrone NDA to FDA's Office of New Drugs for re-review

Cell Therapeutics, today announced that the Office of New Drugs of the U.S. Food and Drug Administration after carefully reviewing the materials CTI submitted in support of its appeal, the reviews of the New Drug Application for pixantrone prepared by the FDA staff, the transcript of the March 22, 2010 Oncology Drugs Advisory Committee meeting and consulting with the Center for Drug Evaluation and Research's Deputy Director of Clinical Science and the Office of Biostatistics, concluded that accelerated approval of pixantrone NDA 022481 may not necessarily be out of reach based on a single controlled clinical trial, provided two key matters can be satisfactorily resolved.

3 May 2011

Althea enters commercial drug supply agreement with Biotest

Althea Technologies, Inc. announced today that they have entered into a commercial supply agreement with Biotest Pharmaceuticals Corporation.

3 May 2011

Boehringer Ingelheim, Eli Lilly receive FDA approval for linagliptin to treat type 2 diabetes

Boehringer Ingelheim and Eli Lilly and Company today announced that the U.S. Food and Drug Administration has approved linagliptin tablets, a prescription medication used along with diet and exercise to lower blood sugar in adults with type 2 diabetes.

3 May 2011

Beta amyloid may inhibit specific cell motors and contribute to memory loss

A protein associated with Alzheimer's disease clogs several motors of the cell transport machinery critical for normal cell division, leading to defective neurons that may contribute to the memory-robbing disease, University of South Florida researchers report.

3 May 2011

McMaster receives new Canadian Cancer Society grants for groundbreaking research

Three cancer studies led by Hamilton researchers are among 52 new research projects worth close to $22 million announced by the Canadian Cancer Society.

3 May 2011

Appeals court greenlights stem-cell research

The court handed the Obama administration a victory by ruling that federal funding of human embryonic stem cell research can go forward.

3 May 2011

New non-invasive device can measure brain's precise temperature

Doctors have long sought a way to directly measure the brain's temperature without inserting a probe through the skull. Now researchers have developed a way to get the brain's precise temperature with a device the diameter of a poker-chip that rests on a patient's head, according to findings presented May 1 at the annual meeting of the Pediatric Academic Societies in Denver.

3 May 2011

Aquaporin-4 plays a key role in brain inflammation

A new protein, called aquaporin-4, is making waves and found to play a key role in brain inflammation, or encephalitis. This discovery is important as the first to identify a role for this protein in inflammation, opening doors for the development of new drugs that treat brain inflammation and other conditions at the cellular level rather than just treating the symptoms.

3 May 2011

Diabetes cell implant company approved for Argentina clinical trial

Living Cell Technologies Limited, a company pioneering the development of a cell implant to treat diabetes, has obtained approval to commence a Phase II DIABECELL clinical trial in Buenos Aires, Argentina, DIABECELL's third jurisdiction to date which has approved human trials. Up to eight adult patients with Type 1 diabetes, including those with unstable diabetes and severe hypoglycaemia, will each receive two implants of DIABECELL, three months apart with a dose seeking component. The trial is expected to begin in the second half of this year.

3 May 2011

New insight into itch and pain

A new study of itch adds to growing evidence that the chemical signals that make us want to scratch are the same signals that make us wince in pain.

3 May 2011

New antioxidant may prevent liver damage in chronic alcoholics

An antioxidant may prevent damage to the liver caused by excessive alcohol, according to new research from the University of Alabama at Birmingham.

3 May 2011

Animal studies reveal new route to treating heart disease

Scientists at Johns Hopkins have shown in laboratory experiments in mice that blocking the action of a signaling protein deep inside the heart’s muscle cells blunts the most serious ill effects of high blood pressure on the heart. These include heart muscle enlargement, scar tissue formation and loss of blood vessel growth.

2 May 2011

First Edition: May 2, 2011

With Congress due back to work in Washington, D.C., after its spring recess, the next stage of the budget battle is expected to heat up. News reports detail the part Medicare and Medicaid will play in the debate.

2 May 2011

FDA accepts SGEN's brentuximab vedotin BLAs for Hodgkin lymphoma, ALCL treatment

Seattle Genetics, Inc. announced today that the U.S. Food and Drug Administration has accepted for filing two Biologics License Applications for brentuximab vedotin, including one for the treatment of patients with relapsed or refractory Hodgkin lymphoma and one for the treatment of patients with relapsed or refractory systemic anaplastic large cell lymphoma.

2 May 2011