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Planar cell polarity genes control connectivity of enteric neurons

The enteric nervous system (ENS), the "little brain" that resides within the gut wall, governs motility, secretion, and blood flow in the human gastrointestinal tract. Failure of the ENS to develop normally leads to congenital megacolon (Hirschsprung Disease) while loss of normal gut innervation is thought to contribute to debilitating motility disorders, such as irritable bowel syndrome.

11 Mar 2013

Cell fusion studies at Johns Hopkins could lead to improved treatments for muscular dystrophy

Researchers at Johns Hopkins have established a high-efficiency cell-cell fusion system, providing a new model to study how fusion works. The scientists showed that fusion between two cells is not equal and mutual as some assumed, but, rather, is initiated and driven by one of the fusion partners. The discovery, they say, could lead to improved treatments for muscular dystrophy, since muscle regeneration relies on cell fusion to make muscle fibers that contain hundreds or even thousands of nuclei.

8 Mar 2013

AKAP protein alterations implicated in bipolar disorder

Researchers have found increased cellular expression of the postsynaptic signaling protein AKAP5/79 in the anterior cingulate cortex of patients with bipolar disorder.

8 Mar 2013

Researchers uncover cellular-level detail of what happens when bone bears stress over time

From athletes to individuals suffering from osteoporosis, bone fractures are usually the result of tiny cracks accumulating over time -- invisible rivulets of damage that, when coalesced, lead to that painful break.

8 Mar 2013

New technology can turn off genes more precisely, say UCSF researchers

Scientists at UC San Francisco have found a more precise way to turn off genes, a finding that will speed research discoveries and biotech advances and may eventually prove useful in reprogramming cells to regenerate organs and tissues.

8 Mar 2013

Researchers discover ovarian stem-like epithelial cells that can mutate to form tumors

In collaboration with colleagues at Cornell University, a team of cancer researchers at Cold Spring Harbor Laboratory (CSHL) has discovered cells with stem-cell properties in the ovary that can mutate to form tumors.

8 Mar 2013

'Science Speaks' blog reports from 20th Conference on Retroviruses and Opportunistic Infections

The Center for Global Health Policy's "Science Speaks" blog on Wednesday published a series of posts on the 20th Conference on Retroviruses and Opportunistic Infections (CROI), which took place in Atlanta, Georgia, from Sunday to Wednesday.

8 Mar 2013

Family-focused therapy improves mood symptoms in youth at risk of bipolar disorder

A study published in the February 2013 issue of the Journal of the American Academy of Child and Adolescent Psychiatry found that children and adolescents with major depression or subthreshold forms of bipolar disorder - and who had at least one first-degree relative with bipolar disorder - responded better to a 12-session family-focused treatment than to a briefer educational treatment.

8 Mar 2013

Novel drug seems to increase effectiveness of usual chemotherapy against IBC

Researchers in the University of Delaware's Department of Biological Sciences are investigating a new drug that has shown positive results in early tests of its ability to fight a rare and aggressive form of breast cancer.

8 Mar 2013

Study helps explain why viruses often spread through the brain in patchwork patterns

Viruses often spread through the brain in patchwork patterns, infecting some cells but missing others. New research at Washington University School of Medicine in St. Louis helps explain why. The scientists showed that natural immune defenses that resist viral infection are turned on in some brain cells but switched off in others.

8 Mar 2013

Nearly 90% of young children continue to struggle with ADHD symptoms despite treatment

A study published in the March 2013 issue of the Journal of the American Academy of Child and Adolescent Psychiatry found that 9 out of 10 young children with moderate to severe attention-deficit/hyperactivity disorder (ADHD) continue to experience serious to severe symptoms and impairment long after their original diagnoses, and in many cases, despite treatment.

8 Mar 2013

GENIE public engagement lectures to take place on Mar. 12

If you have ever wondered why a curry feels hot, or about the risks of inherited disease, two eminent experts will give you an answer at a University of Leicester public event.

8 Mar 2013

Minerva scientists convert established human stem cells to the elusive naïve state

Minerva Biotechnologies, a leading cancer and stem cell development company today announced a major breakthrough in human stem cell research.

8 Mar 2013

SRSF1 protein can prevent cancerous proliferation by stabilizing p53

Some cellular proteins have multiple, and occasionally opposing, functions. Professor Adrian Krainer and colleagues at Cold Spring Harbor Laboratory demonstrate in a paper published online today in Molecular Cell that the oncogenic protein SRSF1 can also trigger a stop in cell growth and prevent cancerous proliferation by stabilizing p53, the powerful tumor-suppressor protein.

8 Mar 2013

Acid reflux can kill certain cancer cells

A University of Central Florida chemist has come up with a unique way to kill certain cancer cells - give them acid reflux.

7 Mar 2013

Acceleron commences ACE-536 phase 2 study in beta-thalassemia

Acceleron Pharma, Inc., a biopharmaceutical company developing protein therapeutics for cancer and orphan diseases, today announced the initiation of a phase 2 study of its novel, investigational protein therapeutic, ACE-536, to treat patients with beta-thalassemia, a genetic hematologic disorder causing chronic and life-threatening anemia and serious complications affecting the spleen, liver and heart.

7 Mar 2013

Salk epigenetic findings may aid in crop production and study of human diseases

Scientists at the Salk Institute for Biological Studies have identified patterns of epigenomic diversity that not only allow plants to adapt to various environments, but could also benefit crop production and the study of human diseases.

7 Mar 2013

CALHM1 channel protein releases ATP to make neural taste connections

Saying that the sense of taste is complicated is an understatement, that it is little understood, even more so. Exactly how cells transmit taste information to the brain for three out of the five primary taste types was pretty much a mystery, until now.

7 Mar 2013

USF, Saneron receive patent for transplantation method using umbilical cord blood cells

Researchers at Saneron CCEL Therapeutics and the University of South Florida have received a patent relating to a method for obtaining and using umbilical cord blood cells from a donor or patient to provide neural cells for transplantation aimed at repairing a variety of neurodegenerative diseases of the brain and spinal cord, such as Parkinson's disease, Huntington's disease, multiple sclerosis, Alzheimer's disease as well as brain and spinal cord injury.

7 Mar 2013

Study reveals increased dietary salt intake may lead to autoimmune disorders

Increased dietary salt intake can induce a group of aggressive immune cells that are involved in triggering and sustaining autoimmune diseases.

7 Mar 2013

Cell News and Research

Planar cell polarity genes control connectivity of enteric neurons

Cell fusion studies at Johns Hopkins could lead to improved treatments for muscular dystrophy

AKAP protein alterations implicated in bipolar disorder

Researchers uncover cellular-level detail of what happens when bone bears stress over time

New technology can turn off genes more precisely, say UCSF researchers

Researchers discover ovarian stem-like epithelial cells that can mutate to form tumors

'Science Speaks' blog reports from 20th Conference on Retroviruses and Opportunistic Infections

Family-focused therapy improves mood symptoms in youth at risk of bipolar disorder

Novel drug seems to increase effectiveness of usual chemotherapy against IBC

Study helps explain why viruses often spread through the brain in patchwork patterns

Nearly 90% of young children continue to struggle with ADHD symptoms despite treatment

GENIE public engagement lectures to take place on Mar. 12

Minerva scientists convert established human stem cells to the elusive naïve state

SRSF1 protein can prevent cancerous proliferation by stabilizing p53

Acid reflux can kill certain cancer cells

Acceleron commences ACE-536 phase 2 study in beta-thalassemia

Salk epigenetic findings may aid in crop production and study of human diseases

CALHM1 channel protein releases ATP to make neural taste connections

USF, Saneron receive patent for transplantation method using umbilical cord blood cells

Study reveals increased dietary salt intake may lead to autoimmune disorders

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