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Tumors 'not always greatest mortality risk in RCC patients'

Patients with localized solid kidney tumors may be at greater risk for death from non-cancer-related causes before that from disease progression and cancer-related mortality, say US researchers who developed a comorbidity-based risk prediction model.

22 Nov 2012

Tumour burden predicts prognosis in mRCC

Tumor burden plays an independent prognostic and predictive role in metastatic renal cell carcinoma, a clinical trial shows.

22 Nov 2012

Temsirolimus effective for mRCC patients on hemodialysis

Research findings published in the International Journal of Clinical Oncology suggest that temsirolimus effectively stabilizes disease progression in patients with metastatic renal cell carcinoma undergoing hemodialysis.

22 Nov 2012

TGF-betaR inhibitors may counter drug resistance in cancer patients with MED12 mutations

Cancer therapies often have short-lived benefits due to the emergence of genetic mutations that cause drug resistance. A key gene that determines resistance to a range of cancer drugs has been reported in a study published by Cell Press November 21st in the journal Cell.

22 Nov 2012

Coronary arteries largely arise from cells of the endocardium

During embryonic development, the all-important coronary arteries arise from cells previously considered incapable of producing them, according to scientists at Albert Einstein College of Medicine of Yeshiva University.

22 Nov 2012

Researchers define structure of Cdc13 protein in yeast

Chromosomes - long, linear DNA molecules - are capped at their ends with special DNA structures called telomeres and an assortment of proteins, which together act as a protective sheath. Telomeres are maintained through the interactions between an enzyme, telomerase, and several accessory proteins. Researchers at The Wistar Institute have defined the structure of one of these critical proteins in yeast.

22 Nov 2012

Methylome modifications offer new measure of a person's biological age

Women live longer than men. Individuals can appear or feel years younger - or older - than their chronological age. Diseases can affect our aging process. When it comes to biology, our clocks clearly tick differently.

22 Nov 2012

Obesity and oxidative stress: an interview with Dr Elizabeth New

Even though oxygen is essential for us to live, it can react with other compounds in the body to produce molecules called free radicals, which are highly reactive and damaging.

22 Nov 2012

Important knowledge about how stem cells develop best into insulin-producing cells

Scientists from The Danish Stem Cell Center (DanStem) at the University of Copenhagen are contributing important knowledge about how stem cells develop best into insulin-producing cells. In the long term this new knowledge can improve diabetes treatment with cell therapy.

22 Nov 2012

IRCM researchers discover a nerve cell's internal clock

A team of IRCM researchers, led by Dr. Fr-d-ric Charron, recently uncovered a nerve cell's internal clock, used during embryonic development.

22 Nov 2012

Scientists discover telomerase as cause of chronic inflammation in human cancers

A*STAR scientists have identified the enzyme, telomerase, as a cause of chronic inflammation in human cancers. Chronic inflammation is now recognized as a key underlying cause for the development of many human cancers, autoimmune disorders, neurodegenerative diseases, and metabolic diseases such as diabetes.

22 Nov 2012

Crucial link between protein synthesis and autism spectrum disorders

Researchers from McGill University and the University of Montreal have identified a crucial link between protein synthesis and autism spectrum disorders (ASD), which can bolster new therapeutic avenues.

22 Nov 2012

Heidelberg researchers uncover function of specific molecular chaperones

Clumped proteins can be dissolved with the aid of cellular repair systems - a process of critical importance for cell survival especially under conditions of stress. Heidelberg researchers have now decrypted the fundamental mechanism for dissolving protein aggregates that involves specific molecular chaperones.

22 Nov 2012

Study provides new insight into human cognitive function and risk for neurological diseases

Short snippets of DNA found in human brain tissue provide new insight into human cognitive function and risk for developing certain neurological diseases, according to researchers from the Departments of Psychiatry and Neuroscience at Mount Sinai School of Medicine. The findings are published in the November 20th issue of PLoS Biology.

22 Nov 2012

Kidney tumors may be smarter than previously thought

New research has found there are several different ways that kidney tumours can achieve the same result - namely, grow.

22 Nov 2012

MicroRNAs in ovarian cancer cells promote tumor growth

Unraveling the mechanism that ovarian cancer cells use to change normal cells around them into cells that promote tumor growth has identified several new targets for treatment of this deadly disease.

22 Nov 2012

Inhaled nitric oxide reduces adverse effects of stored blood transfusion in mice

Inhaled nitric oxide reduced the adverse effects of transfusing stored blood in mice, according to a study from the December issue of Anesthesiology. Researchers found that inhaled nitric oxide reduced tissue injury and improved short-term survival in mice that were resuscitated with a stored blood transfusion after hemorrhagic shock.

22 Nov 2012