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Study finds specific way in which Salmonella counteract defense mechanisms of human cells

A new study by researchers at Imperial College London has identified a way in which Salmonella bacteria, which cause gastroenteritis and typhoid fever, counteract the defence mechanisms of human cells.

16 Nov 2012

Electrical engineers develop new technology to monitor medical vital signs

Electrical engineers at Oregon State University have developed new technology to monitor medical vital signs, with sophisticated sensors so small and cheap they could fit onto a bandage, be manufactured in high volumes and cost less than a quarter.

16 Nov 2012

RXi announces pharmacokinetic results from RXI-109 Phase 1 study in healthy subjects

RXi Pharmaceuticals Corporation, a biotechnology company focused on discovering, developing and commercializing innovative therapies addressing major unmet medical needs using RNA-targeted technologies, today announced the pharmacokinetic results of their single dose Phase 1 study with RXI-109 in healthy subjects.

15 Nov 2012

Gene therapy shows promise against dry mouth in cancer patients

Injecting an adenoviral vector encoding human aquaporin-1 into the parotid glands of head and neck cancer survivors improves their symptoms of dry mouth induced by radiation therapy, show study results.

15 Nov 2012

Braking mechanism in olfactory neurons helps generate amazing diversity of sensors in the nose

The human nose has millions of olfactory neurons grouped into hundreds of different neuron types. Each of these neuron types expresses only one odorant receptor, and all neurons expressing the same odorant receptor plug into one region in the brain, an organization that allows for specific odors to be sensed.

15 Nov 2012

Promising new minimally toxic approach to treat solid tumors with radiation

A promising new approach to treating solid tumors with radiation was highly efficacious and minimally toxic to healthy tissue in a mouse model of cancer, according to data published in Cancer Research, a journal of the American Association for Cancer Research.

15 Nov 2012

Researchers describe structure of active site core of topoisomerase II alpha anti-cancer drug target

A group of researchers at the University of California, Berkeley have for the first time described the structure of the active site core of topoisomerase II alpha, an important target for anti-cancer drugs.

15 Nov 2012

RainDance's ThunderStorm System for targeted sequencing selected by UCL Cancer Institute

RainDance Technologies, Inc., the Digital Biology Company, today announced that the University College London (UCL) Cancer Institute has adopted its ThunderStorm System as a centralized platform for the validation of genomic and epigenomic targets from clinical and non-clinical studies, including follow-ups for genome-wide and epigenome-wide association studies (GWAS and EWAS), as well as stratified cancer medicine and basic research.

15 Nov 2012

Simple iron control mechanism can prevent development of severe forms of malaria

Malaria is a life-threatening condition that exposes approximately half of the world's population to the risk of developing a severe and often lethal form of disease. In a study published in the latest issue of the journal Cell Host & Microbe*, Miguel Soares and his team at Instituto Gulbenkian de Ci-ncia (IGC), Portugal, discovered that the development of severe forms of malaria can be prevented by a simple mechanism that controls the accumulation of iron in tissues of the infected host.

15 Nov 2012

EU approves Forxiga for treatment of type 2 diabetes

Bristol-Myers Squibb Company and AstraZeneca today announced that the European Commission has approved Forxiga (dapagliflozin) tablets for the treatment of type 2 diabetes in the European Union. Forxiga is a selective and reversible inhibitor of sodium-glucose cotransporter 2 (SGLT2) that works independently of insulin to help remove excess glucose from the body, a unique mode of action not seen in any other currently available treatments for type 2 diabetes.

15 Nov 2012

AKT1 genotype influences risk of psychotic disorders in cannabis users

The ability of cannabis to produce psychosis has long been an important public health concern. This concern is growing in importance as there is emerging data that cannabis exposure during adolescence may increase the risk of developing schizophrenia, a serious psychotic disorder. Further, with the advent of medical marijuana, a new group of people with uncertain psychosis risk may be exposed to cannabis.

15 Nov 2012

Pancreas stem cells can be turned into insulin producing cells

Stem cells in the adult pancreas have been identified that can be turned into insulin producing cells, a finding that means people with type 1 diabetes might one day be able to regenerate their own insulin-producing cells.

15 Nov 2012

Study on effect of glucose on cancer growth in mice

An animal study conducted by researchers at Georgetown Lombardi Comprehensive Cancer Center raises questions about the consequences of diet - specifically glucose, the plant-based sugar that fuels cell life - on increased activity of an oncogene that drives tumor growth.

15 Nov 2012

Myasthenia gravis therapies: an interview with Professor Daniel Drachman

Myasthenia gravis (MG) is an autoimmune disease that produces weakness and fatiguability of muscles. It affects between 1 and 7 people per 10,000, according to the best statistics.

15 Nov 2012

UiO researchers discover enzyme critical for spread of cancer

Enzyme hunters at UiO have discovered the function of an enzyme that is important in the spreading of cancer. Cancer researchers now hope to inhibit the enzyme.

15 Nov 2012

Smoking affects development of peripheral allergy-relevant stem cells in the blood

Environmental contaminants, such as smoking, are harmful to the human organism in relation to the occurrence of allergies. This is known. Until now, researchers had never investigated whether and to what extent environmental contaminants also affect allergy-relevant stem cells.

15 Nov 2012

Viruses to treat metastatic cancers

There exists a "type" of cancer that is common yet rarely discussed—metastatic cancer, or cancer that has spread from the part of the body where it originated (the primary tumor) to another (such as lungs, bones or liver). Although much research is being done to combat primary tumors, there still exists a crucial need to find a treatment that can be effective against metastatic cancer, or "mets." Could a virus be the answer that finally beats the mets?

15 Nov 2012

Paxvax PXVX0200 cholera vaccine demonstrates safety and immunogenicity in Phase 1 clinical trial

PaxVax Inc, which develops and commercializes innovative vaccines against infectious diseases in a socially responsible manner today announced results from a Phase 1 clinical trial of PaxVax's single-dose oral cholera vaccine candidate at the 2012 American Society of Tropical Medicine and Hygiene (ASTMH) Annual Meeting in Atlanta.

15 Nov 2012

ALN RNAi therapeutic program represents novel approach for treatment of AAT deficiency

Alnylam Pharmaceuticals, Inc., a leading RNAi therapeutics company, announced today that it has presented new pre-clinical data with an RNAi therapeutic targeting alpha-1 antitrypsin (AAT) for the treatment of liver disease associated with AAT deficiency. These data were presented at the 63rd Annual Meeting of the American Association for the Study of Liver Diseases (AASLD, "The Liver Meeting") held November 9-13, 2012 in Boston.

15 Nov 2012

Tuberculosis pathogen has an ingenious defence mechanism against oxygen

Flemish biologists lead by Joris Messens (VIB / Vrije Universiteit Brussel) have discovered that Mycobacterium tuberculosis - the bacterium that causes tuberculosis - has an ingenious defence mechanism against oxygen. This knowledge is important in the search for a treatment for tuberculosis. 9.4 million people are infected with tuberculosis annually and 1.7 million people die as a result.

15 Nov 2012

Cell News and Research

Study finds specific way in which Salmonella counteract defense mechanisms of human cells

Electrical engineers develop new technology to monitor medical vital signs

RXi announces pharmacokinetic results from RXI-109 Phase 1 study in healthy subjects

Gene therapy shows promise against dry mouth in cancer patients

Braking mechanism in olfactory neurons helps generate amazing diversity of sensors in the nose

Promising new minimally toxic approach to treat solid tumors with radiation

Researchers describe structure of active site core of topoisomerase II alpha anti-cancer drug target

RainDance's ThunderStorm System for targeted sequencing selected by UCL Cancer Institute

Simple iron control mechanism can prevent development of severe forms of malaria

EU approves Forxiga for treatment of type 2 diabetes

AKT1 genotype influences risk of psychotic disorders in cannabis users

Pancreas stem cells can be turned into insulin producing cells

Study on effect of glucose on cancer growth in mice

Myasthenia gravis therapies: an interview with Professor Daniel Drachman

UiO researchers discover enzyme critical for spread of cancer

Smoking affects development of peripheral allergy-relevant stem cells in the blood

Viruses to treat metastatic cancers

Paxvax PXVX0200 cholera vaccine demonstrates safety and immunogenicity in Phase 1 clinical trial

ALN RNAi therapeutic program represents novel approach for treatment of AAT deficiency

Tuberculosis pathogen has an ingenious defence mechanism against oxygen

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