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Scientists discover new mechanism for regulation of AQP function

Scientists at Aston University (UK) have identified a new mechanism responsible for regulating the flow of water into and out of cells. This discovery will improve understanding of how the body maintains its water balance in health and disease.

25 Apr 2012

Impaired mitochondrial function may play a major role in mood and psychotic disorders

Janssen Research & Development, LLC announced today the publication of an article that reviews the growing evidence that impaired mitochondrial function may play a major role in mood and psychotic disorders.

25 Apr 2012

CML and B-ALL arise from the long-term haematopoietic stem cells

Although people generally talk about "cancer", it is clear that the disease occurs in a bewildering variety of forms. Even single groups of cancers, such as those of the white blood cells, may show widely differing properties. How do the various cancers arise and what factors determine their progression? Clues to these two issues, at least for leukaemias, have now been provided by Boris Kovacic and colleagues at the University of Veterinary Medicine, Vienna.

25 Apr 2012

Clinical trial to evaluate IGF-1 in children with SHANK3 deficiency

In an important test of one of the first drugs to target core symptoms of autism, researchers at Mount Sinai School of Medicine are undertaking a pilot clinical trial to evaluate insulin-like growth factor (IGF-1) in children who have SHANK3 deficiency (also known as 22q13 Deletion Syndrome or Phelan-McDermid Syndrome), a known cause of autism spectrum disorder (ASD).

25 Apr 2012

Crucell, ARTES enter research collaboration to develop two vaccines

ARTES Biotechnology, specialized in recombinant protein production and process development in microbial expression systems, started a development collaboration for two vaccines together with global biopharmaceutical company Crucell. Crucell is focused on the research & development, production and marketing of vaccines and antibodies against infectious disease worldwide.

25 Apr 2012

Study sheds light on how stress differently affects women’s hearts

Coronary artery disease continues to be a major cause of death in the U.S., killing hundreds of thousands of people per year. However, this disease burden isn't evenly divided between the sexes; significantly more men than women are diagnosed with coronary artery disease each year. The reasons behind this difference aren't well defined. Though some studies have shown that men's hearts become more constricted than women's during exercise, letting less blood flow through, women are more likely than men to have symptoms of heart trouble after emotional upsets.

25 Apr 2012

Mylan receives final FDA approval for generic Zyprexa ANDA

Mylan Inc. today announced that its subsidiary Mylan Pharmaceuticals Inc. has received final approval from the U.S. Food and Drug Administration (FDA) for its Abbreviated New Drug Application (ANDA) for Olanzapine Tablets USP, 2.5 mg, 5 mg, 7.5 mg, 10 mg, 15 mg, and 20 mg.

25 Apr 2012

Stress can shorten telomeres at a very young age

Children who have experienced violence might really be older than their years. The DNA of 10-year-olds who experienced violence in their young lives has been found to show wear and tear normally associated with aging, a Duke University study has found.

24 Apr 2012

CRG to host EuroStemCell meeting on April 27

Stem cells are in the news quite a bit, but it can be difficult to pick out the true science from the hype. How can patients, school students and members of the public make sense of this fast-changing area of research? EuroStemCell aims to meet this challenge and engage the public in developments in this complex area of science.

24 Apr 2012

Researchers discover how dendritic cells exchange information to amplify immune response

Using a new fluorescent biosensor they developed, researchers at Carnegie Mellon University have discovered how a key set of immune cells exchange information during their coordinated assault on invading pathogens.

24 Apr 2012

Researchers develop small endoscopic device fitted with femtosecond laser scalpel

Whether surgeons slice with a traditional scalpel or cut away with a surgical laser, most medical operations end up removing some healthy tissue, along with the bad. This means that for delicate areas like the brain, throat, and digestive tract, physicians and patients have to balance the benefits of treatment against possible collateral damage.

24 Apr 2012

Computational adaptive optics for real-time in-vivo applications

Real-time, 3-D microscopic tissue imaging could be a revolution for medical fields such as cancer diagnosis, minimally invasive surgery and ophthalmology. University of Illinois researchers have developed a technique to computationally correct for aberrations in optical tomography, bringing the future of medical imaging into focus.

24 Apr 2012

Researchers describe novel mechanism of HIV-1 spread by dendritic cells

A new understanding of the initial interactions of human immunodeficiency virus type 1 (HIV-1) and dendritic cells is described by Boston University School of Medicine (BUSM) researchers in a study currently featured in the Proceedings of the National Academy of Sciences.

24 Apr 2012

Scientists identify new way to deliver long-lasting pain relief

Scientists at the University of North Carolina at Chapel Hill have identified a new way to deliver long-lasting pain relief through an ancient medical practice.

24 Apr 2012

Cadmium exposure can cause progression of aggressive breast cancer

Studies by researchers at Dominican University of California show that breast cancer cells become increasingly aggressive the longer they are exposed to small concentrations of cadmium, a heavy metal commonly found in cosmetics, food, water and air particles.

24 Apr 2012

Cancer therapy with common cold virus

Common viruses have become the latest weapon against cancer. There is the case of the eight-year-old African boy diagnosed with Burkitt's lymphoma at a Ugandan health clinic. He was exposed to the measles virus and in the next few weeks his tumour regressed completely and he entered remission. But only relatively recently have scientists clinically examined the interaction between viruses and cancers in the growing area of oncolytic virotherapy.

24 Apr 2012

Study: hUC-MSCs reduce inflammation that causes colitis

When laboratory mice were modeled with colitis and treated with human umbilical cord-derived mesenchymal cells, the cells homed in on the inflamed colon and effectively ameliorated colitis, reported a study published in a recent issue of Cell Transplantation.

24 Apr 2012

TopBP1 protein prevents early brain cells from DNA damage

St. Jude Children's Research Hospital scientists have rewritten the job description of the protein TopBP1 after demonstrating that it guards early brain cells from DNA damage. Such damage might foreshadow later problems, including cancer.

24 Apr 2012

Novel technological treatment for Leber Hereditary Optic Neuropathy

A research team, led by John Guy, M.D., professor of ophthalmology at Bascom Palmer Eye Institute of the University of Miami Miller School of Medicine, has pioneered a novel technological treatment for Leber Hereditary Optic Neuropathy (LHON), an inherited genetic defect that causes rapid, permanent, and bilateral loss of vision in people of all ages, but primarily males ages 20-40.

24 Apr 2012

HDAC6 protein may provide novel target for stress-linked disorders

A cellular protein called HDAC6, newly characterized as a gatekeeper of steroid biology in the brain, may provide a novel target for treating and preventing stress-linked disorders, such as depression and post-traumatic stress disorder (PTSD), according to research from the Perelman School of Medicine at the University of Pennsylvania.

24 Apr 2012