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Oncology drug development services: an interview with Dr. Jean-Pierre Wery, President of Crown Bioscience, Inc.

Crown serves pharmaceutical companies and biotech companies. We have two areas of focus: oncology and metabolic diseases. In the oncology space we focus on pre-clinical services. Essentially, we have all the tools to help our customers move from target discovery, target validation, to a clinical candidate.

31 Oct 2013

Researchers receive grant to develop new device that identifies healthy sperm cells for IVF

The World Health Organization estimates more than 70 million couples worldwide are unable to conceive each year, with close to a third of those cases attributable solely to issues with male fertility-including low sperm count and low sperm motility (a limited ability to swim).

31 Oct 2013

New understanding of sperm capacitation may improve IVF success rates

Two new papers from reproductive biologists at the University of Massachusetts Amherst, with international partners, report advances in understanding the basic processes of sperm capacitation that may one day improve success rates of in vitro fertilization (IVF) by providing a shortcut to bypass problems, and may eventually lead to a male contraceptive.

29 Oct 2013

Current drugs may harbor small-cell lung cancer promise

Scientists have identified several existing non-oncology drug classes that may have potential as a treatment for small-cell lung cancer, especially for patients with chemoresistant and metastatic disease.

28 Oct 2013

Whitehead Institute scientists identify novel Parkinson's disease drug target

Using a discovery platform whose components range from yeast cells to human stem cells, Whitehead Institute scientists have identified a novel Parkinson's disease drug target and a compound capable of repairing neurons derived from Parkinson's patients.

25 Oct 2013

Diffregen awarded SBIR Phase 1 grant to advance Angiocidin towards human clinical trials

Diffregen LLC, a Temple University startup company, has been awarded a small business innovation research Phase 1 grant by the National Cancer Institute to advance Angiocidin, a university-created therapeutic to treat acute myeloid leukemia, to the doorstep of human clinical trials.

24 Oct 2013

Functional biomarker could help guide treatment of patients with BRAF-mutant melanomas

A functional biomarker that can predict whether BRAF-mutant melanomas respond to drugs targeting BRAF could help guide the treatment of patients with these cancers, according to results presented here at the AACR-NCI-EORTC International Conference on Molecular Targets and Cancer Therapeutics, held Oct. 19 - 23.

23 Oct 2013

Verastem presents positive results from VS-6063 clinical and preclinical studies at 2013 AACR-NCI-EORTC meeting

Verastem, Inc., focused on discovering and developing drugs to treat cancer by the targeted killing of cancer stem cells, announced positive results from the Phase 1 portion of its Phase 1/1b study of defactinib (VS-6063) in combination with paclitaxel in patients with ovarian cancer that were presented at the 2013 AACR-NCI-EORTC International Conference on Molecular Targets and Cancer Therapeutics in Boston.

21 Oct 2013

Wnt5A signaling pathway helps researchers determine who may respond to BRAF inhibitors

One of the challenges of understanding cancer is trying to determine the mechanisms that drive metastasis, or the process by which tumor cells are able to spread throughout the body.

19 Oct 2013

CIRM President Steps Down After Six Years

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18 Oct 2013

Stem Cell Therapeutics Nabs Sirpa Protein-Targeting Mabs

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18 Oct 2013

Study finds increase in use of donor eggs for in vitro fertilization

Between 2000 and 2010 in the United States the number of donor eggs used for in vitro fertilization increased, and outcomes for births from those donor eggs improved, according to a study published by JAMA. The study is being released early online to coincide with its presentation at the American Society for Reproductive Medicine and the International Federation of Fertility Societies joint annual meeting.

18 Oct 2013

Stem Cell Therapeutics Nabs Sirpa Protein-Targeting Mabs

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17 Oct 2013

Celmatix presents six research findings at ASRM's annual meeting

Celmatix, a biotechnology company focused on helping physicians guide patients to treatments that maximize their personal reproductive potential, announced today six research presentations at the annual meeting of the American Society for Reproductive Medicine, being held October 12-17 in Boston.

17 Oct 2013

Crown Bioscience enters into collaboration with Xstrahl for radiation biology research

Crown Bioscience, Inc., a leading global drug discovery and development service company, today announces that it has entered into a collaboration with Xstrahl Ltd, a leading designer and manufacturer of X-Ray solutions for radiation biology research.

From Xstrahl 15 Oct 2013

Research findings may lead to potential treatments for inherited diseases

New research from the University of California, Davis, shows that the tiny proportion of a cell's DNA that is located outside the cell nucleus has a disproportionately large effect on a cell's metabolism.

12 Oct 2013

IVF and chromosome testing: an interview with Dr. Santiago Munné

The Society for Assisted Reproductive Technology (SART) releases every year a report on pregnancy rates by maternal age. The last one shows a decline on implantation rates per embryo from 36% in young women, to 27.3% in women 35-37, 17.5% in 38-40, and less than 10% above 40 years of age.

10 Oct 2013

CHD Bioscience's lead product can help mitigate increasing threat of HAIs

According to a recent report issued by the Centers for Disease Control, every year more than two million people develop infections that are resistant to antibiotics. Specific healthcare-associated infections are classified as urgent threats and affect approximately 1.7 million people annually across the United States, leading to death in nearly 99,000 patients.

9 Oct 2013

Research: VIP interneurons inhibit activation of other inhibitory neurons in cerebral cortex

The cerebral cortex contains two major types of neurons: principal neurons that are excitatory and interneurons that are inhibitory, all interconnected within the same network.

7 Oct 2013

Longer looks: Chinese medicine; revolutionary doctors; frozen embryos

A few years ago, while visiting Beijing, I caught a cold. My wife, who is Chinese, and wanted me to feel better, took me to a local restaurant. After we sat down, she ordered a live turtle.

5 Oct 2013

in vitro News and Research

Oncology drug development services: an interview with Dr. Jean-Pierre Wery, President of Crown Bioscience, Inc.

Researchers receive grant to develop new device that identifies healthy sperm cells for IVF

New understanding of sperm capacitation may improve IVF success rates

Current drugs may harbor small-cell lung cancer promise

Whitehead Institute scientists identify novel Parkinson's disease drug target

Diffregen awarded SBIR Phase 1 grant to advance Angiocidin towards human clinical trials

Functional biomarker could help guide treatment of patients with BRAF-mutant melanomas

Verastem presents positive results from VS-6063 clinical and preclinical studies at 2013 AACR-NCI-EORTC meeting

Wnt5A signaling pathway helps researchers determine who may respond to BRAF inhibitors

CIRM President Steps Down After Six Years

Stem Cell Therapeutics Nabs Sirpa Protein-Targeting Mabs

Study finds increase in use of donor eggs for in vitro fertilization

Stem Cell Therapeutics Nabs Sirpa Protein-Targeting Mabs

Celmatix presents six research findings at ASRM's annual meeting

Crown Bioscience enters into collaboration with Xstrahl for radiation biology research

Research findings may lead to potential treatments for inherited diseases

IVF and chromosome testing: an interview with Dr. Santiago Munné

CHD Bioscience's lead product can help mitigate increasing threat of HAIs

Research: VIP interneurons inhibit activation of other inhibitory neurons in cerebral cortex

Longer looks: Chinese medicine; revolutionary doctors; frozen embryos

Human iPSCs: A Full Guide to Advanced in Vitro Models and Applications eBook

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

Expanding access to NMR with the Fourier 80 Duo

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