Immune Response News and Research

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Study evaluates the effectiveness of interferon beta 1b in COVID-19 pneumonia

As the world struggles to overcome the current COVID-19 pandemic with non-pharmacological interventions, in the absence of an effective drug or vaccine, existing immunomodulators are being repurposed. A new study published on the preprint server medRxiv* in May 2020 shows no clinical benefit to the use of one such drug, called interferon beta 1b (IFN beta1b).

22 May 2020

Airway and Celonic collaborate to produce AT-100 as therapeutic candidate against COVID-19

Airway Therapeutics, Inc., a biopharmaceutical company developing a new class of biologics to break the cycle of injury and inflammation for patients with respiratory and inflammatory diseases, and Celonic Group, a premium biopharmaceutical CDMO specialized in the development and production of Advance Therapy Medicinal Products (ATMPs) and mammalian cell line-expressed biotherapeutics, today announced a collaboration to produce the novel human recombinant protein AT-100 (rhSP-D) as a therapeutic candidate against COVID-19.

21 May 2020

Study shows selenium-containing compounds inhibit SARS-CoV-2 replication and assembly

A recent paper by researchers from the Netherlands and Poland provides evidence that modified ebselen derivatives may serve as highly promising prospective drugs against coronavirus disease 2019 (COVID-19). The manuscript is freely available on the bioRxiv* preprint server.

21 May 2020

Computational immunology paves the way for SARS-CoV-2 peptide cocktail vaccine candidate

By employing an immunoinformatics approach, a new study available on the preprint server bioRxiv* shows how the combination of peptides designed from severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) nucleocapsid phosphoprotein and spike glycoprotein may trigger an improved immunological response with respectable safety profile, informing, in turn, further vaccine development.

21 May 2020

Producing virus-specific antibodies after COVID-19

In order to design effective vaccines for COVID-19, we need to understand our immune responses. News-Medical speaks to Professor Chen Dong to find out more.

21 May 2020

Analysis: Get ready for the vaccine — they’re never simple

If there is a silver lining to the flawed U.S. response to the coronavirus pandemic, it is this: The relatively high number of new cases being diagnosed daily — upward of 20,000 — will make it easier to test new vaccines.

21 May 2020

Lattice light-sheet microscopy could help in drug and vaccine development

From testing drugs to developing vaccines, the close study of the immune system is key to improving real-world health outcomes. T-cells are integral to this research, as these white blood cells help tailor the body's immune response to specific pathogens.

21 May 2020

Study focuses on COVID-19 patients with inflammatory rheumatic diseases

The ongoing COVID-19 pandemic has caused nearly five million cases and over 327,000 deaths worldwide. The signs and symptoms of this disease are varied, although there are typical features which assist diagnosis.

20 May 2020

Certain corticosteroid could improve severe COVID-19, say researchers

Researchers at Wayne State University and Henry Ford Health System in Michigan have conducted a study indicating that the corticosteroid methylprednisolone could improve outcomes among patients with severe coronavirus disease 2019 (COVID-19).

20 May 2020

Doctoral candidate receives NIH fellowship to study how adenovirus affects heart function

A dose of adenovirus hits most people like a common cold - a cough, a fever, maybe a sore throat. But for an unfortunate few, the usually benign bug hacks the heart's cellular electrical communication system and sometimes proves fatal.

20 May 2020

New study initiated to establish the presence of SARS-CoV-2 in environmental samples

he Ministry of Science and Innovation, by way of the COVID-19 fund of the Carlos III Health Institute (ISCIII), is funding a study aimed at establishing the presence of SARS-CoV-2 in environmental samples as well as its indirect transmission potential.

20 May 2020

CDC plans nationwide antibody study to determine the magnitude of the coronavirus pandemic

The U.S. Centers for Disease Control and Prevention (CDC) plans to launch a nationwide study to track how the novel coronavirus is spreading across the country.

20 May 2020

Moderna’s coronavirus vaccine candidate shows promise in phase I trial

Moderna, who partnered with the National Institutes of Health, announced that its candidate vaccine appeared to be safe when administered to eight healthy volunteers. The vaccine also stimulated an immune response to the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the virus that causes the coronavirus disease (COVID-19).

20 May 2020

Ortho receives CE mark for COVID-19 IgG antibody test

Ortho Clinical Diagnostics, a global leader of in vitro diagnostics with a rich history of bringing critical tests for infectious diseases to market, today announced its second COVID-19 antibody test—the VITROS Immunodiagnostic Products Anti-SARS-CoV-2 IgG Test received CE Mark. The test offers 100% specificity.

From Ortho-Clinical Diagnostics, Inc. 20 May 2020

Do parasites protect against SARS-CoV-2?

The world has rarely seen such a readily transmissible infection as severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) over the last century. Within five months, the virus has created a Tsunami of COVID-19 positive cases, comprising almost 4.88 million people and causing 322,000 deaths.

19 May 2020

Oxford Immunotec releases the T-SPOT® Discovery™ SARS-CoV-2 kit

Oxford Immunotec Global PLC, a global, high-growth diagnostics company, today announces the release of the T-SPOT Discovery SARS-CoV-2 test kit.

19 May 2020

Common cytokine profile in ARDS, severe COVID-19 and sepsis

Many lives have been lost to the severe pneumonic disease COVID-19 caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), during the ongoing pandemic. The reason for the critical lung injury that results in a fatal outcome in a significant minority of patients has been supposed to be the dramatic oversecretion of pro-inflammatory cytokines and chemokines triggered by the virus.

19 May 2020

New animal model for COVID-19

As the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) continues to ravage the world, scientists are frantically searching for a vaccine or new drug that will effectively counter the lethal effects of the virus that leads to COVID-19 disease.

19 May 2020

Researchers identify intermediate pathway that modifies synthesis and structure of cell wall

An accumulation of an unexpected intermediate of the peptidoglycan recycling pathway that is able to modulate the synthesis and structure of the cell wall, has been found by researchers at Umeå University, Sweden.

19 May 2020

Human immune repertoire may not commonly produce cross-neutralizing antibodies to coronaviruses

Patients infected with either severe acute respiratory syndrome coronavirus (SARS-CoV) or SARS-CoV-2 produce antibodies that bind to the other coronavirus, but the cross-reactive antibodies are not cross protective, at least in cell-culture experiments, researchers report May 17 in the journal Cell Reports.

18 May 2020

Immune Response News and Research

Study evaluates the effectiveness of interferon beta 1b in COVID-19 pneumonia

Airway and Celonic collaborate to produce AT-100 as therapeutic candidate against COVID-19

Study shows selenium-containing compounds inhibit SARS-CoV-2 replication and assembly

Computational immunology paves the way for SARS-CoV-2 peptide cocktail vaccine candidate

Producing virus-specific antibodies after COVID-19

Analysis: Get ready for the vaccine — they’re never simple

Lattice light-sheet microscopy could help in drug and vaccine development

Study focuses on COVID-19 patients with inflammatory rheumatic diseases

Certain corticosteroid could improve severe COVID-19, say researchers

Doctoral candidate receives NIH fellowship to study how adenovirus affects heart function

New study initiated to establish the presence of SARS-CoV-2 in environmental samples

CDC plans nationwide antibody study to determine the magnitude of the coronavirus pandemic

Moderna’s coronavirus vaccine candidate shows promise in phase I trial

Ortho receives CE mark for COVID-19 IgG antibody test

Do parasites protect against SARS-CoV-2?

Oxford Immunotec releases the T-SPOT® Discovery™ SARS-CoV-2 kit

Common cytokine profile in ARDS, severe COVID-19 and sepsis

New animal model for COVID-19

Researchers identify intermediate pathway that modifies synthesis and structure of cell wall

Human immune repertoire may not commonly produce cross-neutralizing antibodies to coronaviruses

Understanding the DNA Damage Response in Innate Immunity eBook

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

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