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TRPC3 emerges as key player in preventing damage from alcohol-associated liver disease

Excessive alcohol intake is strongly associated with alcohol-associated liver disease (ALD) which accounts for 25% and 30% of deaths from cirrhosis and hepatocellular carcinoma. Impairment of Ca2+ influx and Ca2+-mediated signaling in ALD suggests that Ca2+ channels are important in ALD pathological progression.

16 Jan 2024

Palliative telecare provides lasting quality of life improvements for chronically ill patients

Researchers from the University of Colorado Anschutz Medical Campus have found that a team intervention, provided by phone, leads to persistent improvements in depression, anxiety, and quality of life for people managing chronic illnesses.

16 Jan 2024

New strategy makes palliative care more accessible to patients with chronic illnesses

Ordering a palliative care consultation by "default" – via an automatic order programmed into the electronic medical record that doctors may cancel if they choose – is an effective strategy to give more hospitalized patients the opportunity to benefit from palliative care, and sooner, according to a new study led by researchers from the Perelman School of Medicine at the University of Pennsylvania.

16 Jan 2024

Poverty may combine in a synergistic manner with chronic inflammation to reduce health, life expectancy

In the US, approximately 37.9 million people, or 11.4% of the population, lived below the poverty line in 2022.

16 Jan 2024

Natural PLA2 inhibitor from marine fungus combats fatty liver disease by silencing lipotoxic pathways

This new article publication from Acta Pharmaceutica Sinica B, discusses the identification of a natural PLA2 inhibitor from the marine fungus Aspergillus sp. c1 for MAFLD treatment that suppressed lipotoxicity by inhibiting the IRE-1α/XBP-1s axis and JNK signaling.

16 Jan 2024