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New method expands view into activity of single cells

Researchers have devised a way to multiply by more than ten-fold the accessible details of gene activity in individual cells. It's a big leap in the effort to understand cancer development, brain function, immunity and other biological processes driven by the complex interactions of multitudes of different cell types.

6 Jul 2021

Serum testosterone status recovery an accurate predictor of survival in male COVID-19 patients

In a study available on the medRxiv* the preprint server, researchers from Spain showed that testosterone trajectories are very accurate individual predictors of survival in male patients with COVID-19. To better understand the relationship between testosterone levels and disease severity, they studied a group of male and female COVID-19 patients assessing their serum and blood biomarkers in association with outcome of disease.

6 Jul 2021

Mutations in the Epsilon variant contribute to SARS-CoV-2 immune evasion

Three mutations in the Epsilon coronavirus spike protein dampen the neutralizing potency of antibodies induced by current vaccines or past COVID infections.

6 Jul 2021

Castration of male sheep slows DNA aging

Most of us are familiar with the fact that women live longer than men. But fellas, if we told you there was one thing that could be done to increase your lifespan, would you do it?

6 Jul 2021

Study examines evolution and avidity of anti-SARS-CoV-2 IgG antibodies after mRNA vaccination

New research released on the medRxiv* preprint server has measured antibody responses in 71 mRNA vaccinated adults (54 vaccinated with Pfizer and 17 vaccinated with Moderna).

6 Jul 2021

Study explores the effects of SARS-CoV-2 (and other betacoronaviruses) on cellular mRNA processing

A new study has been released on the bioRxiv* preprint server, which deals with a comprehensive survey on alternative splicing concerning SARS-CoV-2 infection. This study has also included two other betacoronavirurses (SARS-CoV and MERS), a control set of unrelated viruses, and a bacterium, namely, Streptococcus pneumonia. The study findings suggest that several cellular parameters are affected owing to a betacoronavirus infection, which in turn affects some genes and invariably various biological functions.

6 Jul 2021

New treatment targeting senescent cells boosts functional recovery from spinal cord injury

Senescent cells prevent tissue recovery following spinal cord injury, and a new drug targeting these cells could therefore improve functional recovery capacity.

6 Jul 2021

Rural ambulance services are in jeopardy as volunteers age and expenses mount

Vern Greyn was standing in the raised bucket of a tractor, trimming dead branches off a tree, when he lost his balance. He fell 12 feet and struck his head on the concrete patio outside his house in this small farming town on the central Montana plains.

6 Jul 2021

Preliminary study shows no need to cease breastfeeding following COVID-19 vaccination

A new study of 13 breastfeeding mothers has shown that components from the COVID-19 vaccine were not found in any breastmilk.

6 Jul 2021

Developing a face mask that can detect COVID-19

A face mask has been developed that can detect COVID-19. News-Medical spoke to the researchers behind this idea to find out more about how it works.

6 Jul 2021

COVID-19 recovered vaccinated individuals more protected from Delta variant

The B.1.617 lineage of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), first detected in October 2020, has led to new outbreaks of the infection and new waves of the pandemic. This infectious lineage has resulted in the generation of sub-lineages such as B.1.617.1 (Kappa), B.1.617.2 (Delta) and B.1.617.3.

6 Jul 2021

CRISPRa identifies potassium channels as neuronal entry factors and druggable targets for SARS-CoV-2

New research led by Le Cong of Stanford University School of Medicine in California indicates that the KCNA6 potassium channel may help with viral entry and promote infection. In addition, KCNA6 is highly expressed in OLIG2+ neuronal cells, which has been shown to be suspectable to SARS-CoV-2 in the olfactory neuroepithelium. This area appears to contribute to loss of smell commonly observed during infection.

6 Jul 2021

Study explores how human ACE2 variants can modify SARS-CoV-2 binding

A recent tour-de-force study by researchers from the United Kingdom reveals variants of the human angiotensin-converting enzyme 2 (ACE2) that can improve or decrease binding of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) – including two variants with distinct population distributions showing an enhanced affinity for viral spike glycoprotein.

5 Jul 2021

Antibiotic clofoctol shows potential against SARS-CoV-2

In a recent study, a group of French researchers aimed to reduce the regulatory preclinical development steps that potential candidates are normally subjected to.

5 Jul 2021

Study says mRNA COVID vaccines are effective against Lambda variant

Researchers in the United States have conducted a study suggesting that the coronavirus disease 2019 (COVID-19) vaccines that are currently being rolled out in many countries should be effective against the C.37 lineage (lambda variant) of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).

5 Jul 2021

Lack of symptoms following COVID-19 mRNA vaccination doesn't mean vaccine not working

A study conducted by researchers from Maryland in the United States has found no correlation between the symptoms that develop following vaccination against coronavirus disease 2019 (COVID-19) and the antibody responses that are generated against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).

5 Jul 2021

Nanomaterials' physiochemical properties influence their ability to penetrate the blood brain barrier

Nanomaterials found in consumer and health-care products can pass from the bloodstream to the brain side of a blood-brain barrier model with varying ease depending on their shape - creating potential neurological impacts that could be both positive and negative, a new study reveals.

5 Jul 2021

Research News and Research

New method expands view into activity of single cells

Serum testosterone status recovery an accurate predictor of survival in male COVID-19 patients

Mutations in the Epsilon variant contribute to SARS-CoV-2 immune evasion

Castration of male sheep slows DNA aging

Study examines evolution and avidity of anti-SARS-CoV-2 IgG antibodies after mRNA vaccination

Study explores the effects of SARS-CoV-2 (and other betacoronaviruses) on cellular mRNA processing

New treatment targeting senescent cells boosts functional recovery from spinal cord injury

Rural ambulance services are in jeopardy as volunteers age and expenses mount

Preliminary study shows no need to cease breastfeeding following COVID-19 vaccination

Developing a face mask that can detect COVID-19

COVID-19 recovered vaccinated individuals more protected from Delta variant

CRISPRa identifies potassium channels as neuronal entry factors and druggable targets for SARS-CoV-2

Study explores how human ACE2 variants can modify SARS-CoV-2 binding

Antibiotic clofoctol shows potential against SARS-CoV-2

Study says mRNA COVID vaccines are effective against Lambda variant

Lack of symptoms following COVID-19 mRNA vaccination doesn't mean vaccine not working

Nanomaterials' physiochemical properties influence their ability to penetrate the blood brain barrier

Viennese scientists awarded grant to find ways for improving and personalizing dialysis care

Bone marrow–derived fibrin clot may become a treatment for meniscus injuries

Exposure to beneficial microorganisms is not affected by targeted hygiene or cleaning

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