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Researchers identify nine blood proteins that alter with age

Loss of muscle mass is not only associated with disease, such as HIV and cancer, but also with the normal aging process. Anabolic steroids are sometimes used to reverse loss of lean muscle tissue but they can have unwanted side effects.

20 Jun 2011

Targeting activity of PKD1 may be beneficial for treatment of polycystic kidney, liver disease

A single gene is central in the development of several forms of polycystic kidney and liver disease, Yale School of Medicine researchers report in the June 19 issue of Nature Genetics.

20 Jun 2011

University of Texas professor recommends three postulates to find probable cause of AD

After more than 100 years following its pathologic description, the cause of Alzheimer's disease (AD) remains unknown. To test the validity of present and future proposals related to the probable cause of AD, three postulates, or necessary conditions, are recommended by Jack de la Torre, MD, PhD, Adjunct Professor of Psychology at the University of Texas, Austin, in an article published in the Journal of Alzheimer's Disease.

20 Jun 2011

Positive results from vismodegib Phase II study on advanced basal cell carcinoma

Genentech, a member of the Roche Group, announced today that a pivotal Phase II study with vismodegib showed positive results in people with advanced basal cell carcinoma (BCC) for whom surgery is considered inappropriate.

20 Jun 2011

Genentech to present positive data from vismodegib Phase II trial on advanced BCC at EADO 2011

Curis, Inc., a drug development company seeking to develop next generation targeted small molecule drug candidates for cancer treatment, today announced that positive data are being presented by its collaborator Genentech, a member of the Roche Group, from a pivotal Phase II clinical trial conducted by Roche and Genentech of vismodegib in patients with advanced basal cell carcinoma, an often life-threatening form of skin cancer that can have disfiguring and debilitating effects.

20 Jun 2011

Scientists discover linchpin protein that drives mitochondria's calcium machinery

Mitochondria, those battery-pack organelles that fuel the energy of almost every living cell, have an insatiable appetite for calcium. Whether in a dish or a living organism, the mitochondria of most organisms eagerly absorb this chemical compound.

20 Jun 2011

New insight into progressive supranuclear palsy

There are new genetic clues on risk factors and biological causes of a rare neurodegenerative disease called progressive supranuclear palsy (PSP), according to a new study from an international genetics team led by researchers from the Perelman School of Medicine at the University of Pennsylvania.

20 Jun 2011

Genomic study identifies MCU that regulates calcium transport into mitochondria

Alnylam Pharmaceuticals, Inc., a leading RNAi therapeutics company, and collaborators at Massachusetts General Hospital (MGH), the Broad Institute, and the David H. Koch Institute for Integrative Cancer Research at the Massachusetts Institute of Technology (MIT), today announced new findings published in Nature.

20 Jun 2011

FDA approves NULOJIX

Bristol-Myers Squibb Company announced that the U.S. Food and Drug Administration (FDA) approved NULOJIX, the first selective T-cell costimulation blocker indicated for the prophylaxis of organ rejection in adult patients receiving a kidney transplant, in combination with basiliximab induction, mycophenolate mofetil (MMF), and corticosteroids.

18 Jun 2011

PDA urges public to undergo screening for oral cancer

Oral cancer claims more lives than leukemia, Hodgkin's lymphoma, laryngeal cancer, testicular cancer, thyroid cancer, or skin cancer. In 2010, approximately 36,540 Americans were diagnosed with this largely preventable type of cancer that affects the mouth and throat; 7,880 died of the disease. Early detection is essential to dramatically reduce the number of deaths from oral cancer.

18 Jun 2011

Patients still being enrolled in clinical trial for new peripheral vascular disease treatment

The first three patients to undergo an investigational surgical procedure for peripheral vascular disease that involves the patient's own stem cells continue to do well, reports the University of Louisville surgeon who is the principal investigator.

18 Jun 2011

Scientists create first roadmap to understand estrogen signaling in breast cancer cells

The first roadmap to mathematical modeling of a powerful basic "decision circuit" in breast cancer has been developed and published in Nature Reviews Cancer.

18 Jun 2011

University of Virginia professor speaks about gender disparity in abdominal aortic aneurysms

At the 65th Vascular Annual Meeting of the Society for Vascular Surgery, Gilbert R. Upchurch, Jr., MD from the division of thoracic and cardiovascular surgery at University of Virginia Health System in Charlottesville, spoke about gender differences in abdominal aortic aneurysms.

18 Jun 2011

Paternal exposure during pregnancy may affect man's ability to father a child

According to the California Teratogen Information Service (CTIS) Pregnancy Health Information Line, more studies are needed to evaluate men and the potential effect of illnesses, medications and lifestyle habits on fertility and pregnancy. For couples suffering fertility problems, the issue is linked to the potential father approximately 50 percent of the time. In close to a quarter of these cases, a specific cause is unknown.

18 Jun 2011

Celgene announces data from REVLIMID plus rituximab Phase II study on malignant lymphomas

Celgene International Sàrl announced that clinical data from a Phase II study, conducted by investigators from the MD Anderson Cancer Center in Houston, TX, evaluating the combination regimen of REVLIMID plus rituximab (R2) in untreated, advanced stage, indolent B-cell non-Hodgkin's lymphomas, were presented at the 11th International Conference on Malignant Lymphoma in Lugano, Switzerland.

18 Jun 2011

Niclosamide drug effective against colon cancer metastasis

A compound that for about 60 years has been used as a drug against tapeworm infection is also apparently effective against colon cancer metastasis, as studies using mice have now shown.

18 Jun 2011

Miracle cures on the horizon for genetic disease

In a latest break through, scientists have found a new technique to alter the genetic code behind hundreds of diseases and this was hailed by U.S. scientists as a “miracle of modern medicine.” Genes responsible for devastating diseases can be corrected by controlling faulty messenger cells that are central to the body's protein production, researchers said Wednesday.

17 Jun 2011

Cancer vaccine shows promise

In the latest research news, a cervical cancer vaccine programme has produced the first evidence of disease prevention among treated women. This vaccine targets human papillomavirus (HPV), the virus believed to trigger cervical cancer in women.

17 Jun 2011

Positive data from Ischemix CMX-2043 Phase 2a trial for peri-operative cardiac ischemia-reperfusion injury

Ischemix today announced positive top line data from a Phase 2a clinical trial of CMX-2043 for the prevention of peri-operative cardiac ischemia-reperfusion injury.

17 Jun 2011

'Healthy food' discussed at Nutrevent 2011

How is "healthy food" defined ? Which food compounds are scientifically approved as health-enhancing ? What type of food information do consumers need or want ? Do "pharma" and "food" need more convergence to be innovative ? These were the most discussed topics during the 2011 edition of the "Nutrevent", an international innovation congress organized by the Eurasanté and the Nutrition, Health and Logevity Cluster in the French city of Lille.

17 Jun 2011

Cell News and Research

Researchers identify nine blood proteins that alter with age

Targeting activity of PKD1 may be beneficial for treatment of polycystic kidney, liver disease

University of Texas professor recommends three postulates to find probable cause of AD

Positive results from vismodegib Phase II study on advanced basal cell carcinoma

Genentech to present positive data from vismodegib Phase II trial on advanced BCC at EADO 2011

Scientists discover linchpin protein that drives mitochondria's calcium machinery

New insight into progressive supranuclear palsy

Genomic study identifies MCU that regulates calcium transport into mitochondria

FDA approves NULOJIX

PDA urges public to undergo screening for oral cancer

Patients still being enrolled in clinical trial for new peripheral vascular disease treatment

Scientists create first roadmap to understand estrogen signaling in breast cancer cells

University of Virginia professor speaks about gender disparity in abdominal aortic aneurysms

Paternal exposure during pregnancy may affect man's ability to father a child

Celgene announces data from REVLIMID plus rituximab Phase II study on malignant lymphomas

Niclosamide drug effective against colon cancer metastasis

Miracle cures on the horizon for genetic disease

Cancer vaccine shows promise

Positive data from Ischemix CMX-2043 Phase 2a trial for peri-operative cardiac ischemia-reperfusion injury

'Healthy food' discussed at Nutrevent 2011

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