Immune Response News and Research

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Removing a gene prevents Type 1 diabetes in mice by disguising beta cells

Removing a gene from the cells that produce insulin prevents mice from developing Type 1 diabetes by sparing the cells an attack from their own immune system, a new UW-Madison study shows.

26 Mar 2020

Highly focused radiation may slow disease progression in men with oligometastatic prostate cancer

Highly focused, intense doses of radiation called stereotactic ablative radiation (SABR) may slow progression of disease in a subset of men with hormone-sensitive prostate cancers that have spread to a few separate sites in the body, according to results of a phase II clinical trial of the therapy.

26 Mar 2020

Intense and targeted radiotherapy could slow progression of certain prostate cancers

Targeted and strong doses of stereotactic ablative radiation (SABR) radiotherapy could slow progression in prostate cancer.

26 Mar 2020

Lipid aids healing of scratches on the cornea

A species of a lipid that naturally helps skin injuries heal appears to also aid repair of common corneal injuries, even when other conditions, like diabetes, make healing difficult, scientists report.

26 Mar 2020

A high salt intake impairs immune response, study suggests

A study has shown that a high salt intake inhibits the immune system’s ability to combat bacteria.

25 Mar 2020

CAR macrophages can be used to effectively fight solid tumors

Chimeric antigen receptor (CAR) T cell therapy has been a game-changer for blood cancers but has faced challenges in targeting solid tumors.

23 Mar 2020

Study helps predict which ovarian cancer patients will not benefit from immune-PARP combo

In patients with advanced ovarian cancer, a combination of drugs known as immune checkpoint inhibitors and PARP inhibitors can produce powerful remissions, clinical trials have shown, but up until now investigators haven't been able to predict which patients won't benefit from the treatment and should explore other options.

19 Mar 2020

Study paves way for identifying ovarian cancer patients who will not benefit from combination therapy

A study suggests it may be possible to identify those who will not benefit from drug combination for advanced ovarian cancer.

19 Mar 2020

New understanding of signaling molecule interleukin-2 can guide drug discovery efforts

The signaling molecule interleukin-2 (IL-2) has long been known to have powerful effects on the immune system, but efforts to harness it for therapeutic purposes have been hampered by serious side effects.

17 Mar 2020

Vaxxas' novel high-density microarray patch can deliver vaccines safely and effectively

Vaxxas, a clinical-stage biotechnology company commercializing a novel vaccination platform, today announced the publication in the journal PLoS Medicine of groundbreaking clinical research indicating the broad immunological and commercial potential of Vaxxas' novel high-density microarray patch.

17 Mar 2020

Melbourne researchers show the body's ability to fight novel coronavirus

Melbourne researchers have mapped immune responses from one of Australia's first novel coronavirus (COVID-19) patients, showing the body's ability to fight the virus and recover from the infection.

17 Mar 2020

Type 1 diabetes mellitus comprises of two different conditions based on age

A new study published in the journal Diabetologia in March 2020 reports that children aged below seven years with type 1 diabetes mellitus (T1DM) have a distinct form of the condition from children aged 13 or more.

15 Mar 2020

Max Planck researchers identify mechanistic basis of antigen receptor gene assembly

Adaptive immunity is a powerful defense mechanism in vertebrates. A finely tuned interplay of different cell types provides a pathogen-specific immune response to eliminate for example bacteria and viruses.

13 Mar 2020

Blood stem cells conserve epigenetic memory of previous infections to boost immunity

These findings should have a significant impact on future vaccination strategies and pave the way for new treatments of an underperforming or over-reacting immune system. The results of this research are published in Cell Stem Cell on March 12, 2020.

13 Mar 2020

What does COVID-19 do to the body?

The novel coronavirus SARS-CoV-2, also known as 2019-nCoV, is the virus that causes COVID-19, and that is spreading throughout the world is causing panic in almost all countries. With a death rate ranging from 1% to 2% in young patients but about 5%-8% in elderly and sick patients, it is capable of ravaging multiple organ systems in the human body.

12 Mar 2020

Study shows how the body's inflammatory response can counterproductively suppress regeneration

In a new peer-reviewed publication, University of Illinois at Chicago researchers describe how the body's response to inflammation, which helps to fight many kinds of infections, also can counterproductively suppress much-needed cell repair and regeneration in blood vessels.

12 Mar 2020

Potential breakthrough in cancer immunotherapy with gasdermin E

A new study published in the journal Nature in March 2020 reports the discovery of a new approach to cancer immunotherapy, which could be useful in many more cancers than at present.

11 Mar 2020

Potential targets for immune responses to novel coronavirus identified

Within two months, SARS-CoV-2, a previously unknown coronavirus, has raced around globe, infecting over a 100,000 people with numbers continuing to rise quickly.

11 Mar 2020

Combination of anti-cancer nanodrugs with Intralipid enhances therapeutic efficacy

Pairing chemotherapy nanodrugs with a nutritional supplement can lessen devastating side-effects while reducing the amount of the expensive drugs needed to treat cancer according to a study from Carnegie Mellon University and Taiwan's National Health Research Institutes.

10 Mar 2020

Gene therapy reverses cardiac dysfunction in mice with Barth syndrome

Barth syndrome is a rare metabolic disease in boys caused by mutation of a gene called tafazzin or TAZ. It can cause life-threatening heart failure and also weakens the skeletal muscles, undercuts the immune response, and impairs overall growth.

9 Mar 2020

Immune Response News and Research

Removing a gene prevents Type 1 diabetes in mice by disguising beta cells

Highly focused radiation may slow disease progression in men with oligometastatic prostate cancer

Intense and targeted radiotherapy could slow progression of certain prostate cancers

Lipid aids healing of scratches on the cornea

A high salt intake impairs immune response, study suggests

CAR macrophages can be used to effectively fight solid tumors

Study helps predict which ovarian cancer patients will not benefit from immune-PARP combo

Study paves way for identifying ovarian cancer patients who will not benefit from combination therapy

New understanding of signaling molecule interleukin-2 can guide drug discovery efforts

Vaxxas' novel high-density microarray patch can deliver vaccines safely and effectively

Melbourne researchers show the body's ability to fight novel coronavirus

Type 1 diabetes mellitus comprises of two different conditions based on age

Max Planck researchers identify mechanistic basis of antigen receptor gene assembly

Blood stem cells conserve epigenetic memory of previous infections to boost immunity

What does COVID-19 do to the body?

Study shows how the body's inflammatory response can counterproductively suppress regeneration

Potential breakthrough in cancer immunotherapy with gasdermin E

Potential targets for immune responses to novel coronavirus identified

Combination of anti-cancer nanodrugs with Intralipid enhances therapeutic efficacy

Gene therapy reverses cardiac dysfunction in mice with Barth syndrome

Exploring Strategies for Targeting Kinases in Innate Immunity eBook

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

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