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Pairing statins with cyclin-dependent kinase inhibitors might effectively treat melanomas

A novel approach to identifying potential anticancer drug combinations revealed that pairing cholesterol-reducing drugs called statins with cyclin-dependent kinase inhibitors might provide an effective approach to treating intractable melanomas driven by mutations in the NRAS and KRAS gene.

14 Dec 2012

China SFDA approves Veridex’s CellSearch test for women with metastatic breast cancer

Veridex, LLC today announced approval from the China State Food & Drug Administration (SFDA) for the CellSearch circulating tumor cell (CTC) test as an in vitro diagnostic for women with metastatic breast cancer.

13 Dec 2012

New way to effectively make designer drugs that hit collections of protein targets simultaneously

An international research collaboration led by scientists at the University of North Carolina School of Medicine and the University of Dundee, in the U.K., have developed a way to efficiently and effectively make designer drugs that hit multiple protein targets at once.

13 Dec 2012

GM604 target regulates over 4,000 genes: Genervon

Genervon scientists have confirmed that the target of GM604 regulates over 4,000 genes. More significantly, it modifies ALS disease progression by modulating at least 30 significant ALS related genes. It does this through at least 8 pathways, potentially more, and up to 22 biological processes.

13 Dec 2012

Angiocidin reduces acute myeloid leukemia cells in vivo by almost two-thirds in pre-clinical studies

Angiocidin, a novel tumor-inhibiting protein, has been shown to reduce acute myeloid leukemia (AML) cells in vivo by almost two-thirds in pre-clinical experiments.

10 Dec 2012

CRP40 may have pathogenic role in schizophrenia

Gene expression of catecholamine-regulated protein 40 is dysregulated in people with schizophrenia, study findings show.

7 Dec 2012

Positive results from NanoString's second clinical study of PAM50-based breast cancer assay

NanoString Technologies, Inc., a privately held provider of life science tools for translational research and developer of molecular diagnostic products, today announced positive results from the second clinical validation study of its in vitro diagnostic breast cancer assay based on the PAM50 gene expression signature.

From NanoString Technologies 7 Dec 2012

Arthrobotrys oligospora produces nanoparticles that could kill tumors

Arthrobotrys oligospora doesn't live a charmed life; it survives on a diet of roundworm. But a discovery by a team led by Mingjun Zhang, an associate professor of biomedical engineering at the University of Tennessee, Knoxville, could give the fungus's life more purpose-as a cancer fighter.

5 Dec 2012

USPTO approves patent for Axiogenesis’ in vitro drug discovery assay to treat HCM

The USPTO approved a patent for Axiogenesis AG for the invention of its in vitro assay to screen pharmaceutical drug candidates for effectiveness and safety in treating Hypertrophic Cardiomyopathy (HCM).

5 Dec 2012

Excess vitamin A intake has calcification repercussions

Excess dietary vitamin A intake is significantly associated with increased heart valve calcification, show results from an animal study.

4 Dec 2012

Innovative stem cell technique for heart tissue revealed

Researchers have found that stem cell cultures infused with growth factors could be used to repair damaged heart tissue without the threat of patient rejection.

3 Dec 2012

Specific transporters could be exploited to deliver toxic substances into cancer cells

Whitehead Institute scientists report that certain molecules present in high concentrations on the surfaces of many cancer cells could be exploited to funnel lethal toxic molecules into the malignant cells. In such an approach, the overexpression of specific transporters could be exploited to deliver toxic substances into cancer cells.

3 Dec 2012

Scientists can produce new proteins by following certain rules

By following certain rules, scientists can prepare architectural plans for building ideal protein molecules not found in the real world. Based on these computer renditions, previously non-existent proteins can be produced from scratch in the lab. The principles to make this happen appear this month in Nature magazine.

1 Dec 2012

Topical simvastatin may be answer to nonhealing diabetic wounds

Topical simvastatin significantly accelerates wound healing in mice and may be a good treatment option for diabetic patients with nonhealing wounds, say researchers.

30 Nov 2012

Epizyme to present data from DOT1L and EZH2 inhibitor programs at 54th ASH annual meeting

Epizyme, Inc., a biopharmaceutical company leading the creation of personalized therapeutics to treat patients with genetically defined cancers, today announced the presentation of data evaluating the preclinical safety and efficacy of two of the Company's novel, potent and selective small molecule inhibitors. These inhibitors individually target DOT1L and EZH2, members of a class of epigenic enzymes called histone methyltransferases (HMTs).

30 Nov 2012

Longer looks: Are 'pods' the solution to our long-term care crisis?; A Liver transplant in the nick of time; Pro-life activists and the abortion drop

In November 2006, when Clara Marshall began suffering from the effects of dementia, her family moved her into ... an assisted living home in Vancouver, Wash. ... just five months into her stay, Ms. Marshall, 81, was found dead in her room apparently strangled after getting her neck caught in side rails used to prevent her from rolling out of bed.

29 Nov 2012

Tufts University researchers demonstrate silk-based implantable optics

Tufts University School of Engineering researchers have demonstrated silk-based implantable optics that offer significant improvement in tissue imaging while simultaneously enabling photo thermal therapy, administering drugs and monitoring drug delivery. The devices also lend themselves to a variety of other biomedical functions.

29 Nov 2012

Topically applied simvastatin enhances wound recovery in diabetic mice

Delayed wound healing is a major complication of diabetes because the physiological changes in tissues and cells impair the wound healing process. This can result in additional disease outcomes such as diabetic foot ulcer, a significant cause of morbidity in the growing population of diabetic patients. A new study has found that topically applied simvastatin accelerates wound healing in diabetic mice, suggesting important implications for humans with diabetes.

28 Nov 2012

Samsung Medison highlights medical devices at RNSA 2012 meeting

Samsung Medison, a leading global medical devices company, announced that it participated the "RSNA (Radiological Society of North America) 2012", held in McCormick Place, Chicago from November 25th to 30th, in the biggest scale thus far.

27 Nov 2012

Avermectin family of drugs shows promise against TB

A well-established family of drugs used to treat parasitic diseases is showing surprising potential as a therapy for tuberculosis (TB), according to new research from University of British Columbia microbiologists.

26 Nov 2012

in vitro News and Research

Pairing statins with cyclin-dependent kinase inhibitors might effectively treat melanomas

China SFDA approves Veridex’s CellSearch test for women with metastatic breast cancer

New way to effectively make designer drugs that hit collections of protein targets simultaneously

GM604 target regulates over 4,000 genes: Genervon

Angiocidin reduces acute myeloid leukemia cells in vivo by almost two-thirds in pre-clinical studies

CRP40 may have pathogenic role in schizophrenia

Positive results from NanoString's second clinical study of PAM50-based breast cancer assay

Arthrobotrys oligospora produces nanoparticles that could kill tumors

USPTO approves patent for Axiogenesis’ in vitro drug discovery assay to treat HCM

Excess vitamin A intake has calcification repercussions

Innovative stem cell technique for heart tissue revealed

Specific transporters could be exploited to deliver toxic substances into cancer cells

Scientists can produce new proteins by following certain rules

Topical simvastatin may be answer to nonhealing diabetic wounds

Epizyme to present data from DOT1L and EZH2 inhibitor programs at 54th ASH annual meeting

Longer looks: Are 'pods' the solution to our long-term care crisis?; A Liver transplant in the nick of time; Pro-life activists and the abortion drop

Tufts University researchers demonstrate silk-based implantable optics

Topically applied simvastatin enhances wound recovery in diabetic mice

Samsung Medison highlights medical devices at RNSA 2012 meeting

Avermectin family of drugs shows promise against TB

Driving innovation in drug discovery with in vitro biology solutions eBook

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

Expanding access to NMR with the Fourier 80 Duo

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