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Receptos begins RPC1063 Phase 1 clinical study in patients with multiple sclerosis

Receptos, announced today that their highly selective sphingosine-1-phosphate receptor 1 agonist, RPC1063, has been administered to the first subject in a single-ascending and multiple-ascending dose design Phase 1 clinical safety study.

28 Jan 2011

Aging-associated protein deficiency may lead to positive breast cancer in women

The most common type of breast cancer in older women - estrogen and progesterone receptor positive breast cancer - has been linked to a protein that fends off aging-related cellular damage.

28 Jan 2011

Iniparib Phase III study in metastatic triple-negative breast cancer does not meet primary goal

Sanofi-aventis and its subsidiary, BiPar Sciences, today announced that a randomized Phase III trial evaluating iniparib (BSI-201) in patients with metastatic triple-negative breast cancer (mTNBC) did not meet the pre-specified criteria for significance for co-primary endpoints of overall survival and progression-free survival

28 Jan 2011

Cardiac stem cell therapy can rebuild damaged heart in children

Visionaries in the field of cardiac therapeutics have long looked to the future when a damaged heart could be rebuilt or repaired by using one's own heart cells. A study published in the February issue of Circulation, a scientific journal of the American Heart Association, shows that heart stem cells from children with congenital heart disease were able to rebuild the damaged heart in the laboratory.

27 Jan 2011

Provectus announces completion of PV-10 Phase 1 trial in patients with liver cancer

Provectus Pharmaceuticals, a development-stage oncology and dermatology biopharmaceutical company, has completed patient accrual and treatment of all subjects in its Phase 1 clinical trial of PV-10 for liver cancer.

27 Jan 2011

Interferon-alpha associated with increased risk of atherosclerosis in patients with SLE

Researchers in China have demonstrated interferon-alpha (IFN-α) is associated with increased risk of atherosclerosis in patients with systemic lupus erythematosus (SLE). For the first time, IFN-α priming was shown to promote lipid uptake and foam cell formation—a crucial step in plaque build-up. This activation of the IFN signaling pathway may be linked to the premature atherosclerosis risk in SLE.

27 Jan 2011

St. Michael's Hospital to build first automated high-throughput zebrafish screening facility in Canada

Zebrafish are the new fruit flies.

27 Jan 2011

As recording technology rapidly improves, neurons give up their secrets cell by cell

Scientists at The Rehabilitation Institute of Chicago (RIC), designated the "#1 Rehabilitation Hospital in America" by U.S. News & World Report since 1991, report that, thanks to improvements in technology and data analysis, our understanding of the functional principles that guide the development and operation of the brain could improve drastically in the next few years.

27 Jan 2011

Scientists discover new mechanism neurons use to fine-tune electrical output

Scientists in the Hotchkiss Brain Institute at the Faculty of Medicine, University of Calgary, have discovered a new mechanism that nerve cells (neurons) use to fine-tune their electrical output. The exciting discovery, published this week in the prestigious journal Nature Neuroscience, provides new insights about how the activity of the nervous system is regulated at the cellular level.

27 Jan 2011

ASAPS supports new national registry for breast implants

The American Society for Aesthetic Plastic Surgery (ASAPS) announces today its support of a new national registry for breast implants that will be compiled by the American Society of Plastic Surgeons (ASPS) in collaboration with the Food and Drug Administration (FDA). This registry will document reported cases of a very rare condition, Anaplastic Large Cell Lymphoma (ALCL), in the presence of breast implants.

27 Jan 2011

Fibroblasts help 'recruit' immune cells for tumor growth

The most common connective tissue cell in animals is the fibroblast, which plays an important role in healing wounds. But Dr. Neta Erez of Tel Aviv University's Sackler Faculty of Medicine has now demonstrated that fibroblasts can also do a body great harm, helping to "recruit" immune cells for tumor growth.

27 Jan 2011

'Phenotype switching' helps bacteria lie dormant inside host cells and become a reservoir for relapsing infections

A new study into Staphylococcus aureus, the bacterium which is responsible for severe chronic infections worldwide, reveals how the bacteria have developed a strategy of hiding within host cells to escape the immune system as well as many antibacterial treatments. The research, published by EMBO Molecular Medicine, demonstrates how 'phenotype switching' enables bacteria to adapt to their environmental conditions, lie dormant inside host cells and become a reservoir for relapsing infections.

27 Jan 2011

First three-dimensional projectome map of intact brain

It would be hard to understand how a city is organized without knowledge of the course of all of its streets. Scientists confront the same problem when trying to understand the functioning of the brain. In the case of vertebrates, we only have fragmentary knowledge of which nerve cells send their connections, so-called axons, into certain regions of the brain.

27 Jan 2011

Molecular mechanism in nerve fibers ensures rapid conductance of nervous system impulses

New research from the University of North Carolina at Chapel Hill School of Medicine describes a key molecular mechanism in nerve fibers that ensures the rapid conductance of nervous system impulses.

27 Jan 2011

AB Science initiates recruitment in masitinib phase 3 study in severe persistent asthma

AB Science SA, a pharmaceutical company specialising in the research, development and commercialisation of protein kinase inhibitors (PKIs), announced today the recruitment of the first patient in the phase 3 study evaluating masitinib in severe persistent asthma.

27 Jan 2011

How estrogen decreases risk and delays onset and progression of Alzheimer's disease

An influential article in the journal Progress in Neurobiology provided one of the first comprehensive reviews of how estrogen potentially can protect against Alzheimer's disease and other neurological disorders.

27 Jan 2011

Study: Removal of B lymphocytes can reverse aging process

Researchers at the Technion-Israel Institute of Technology have discovered a way to reverse the aging process by removing old B lymphocytes from old mice, and forcing the production of young, potent cells to replace them.

27 Jan 2011

Teen brains react with erratic excitement during reward-driven tasks

University of Pittsburgh researchers have recorded neuron activity in adolescent rat brains that could reveal the biological root of the teenage propensity to consider rewards over consequences and explain why adolescents are more vulnerable to drug addiction, behavioral disorders, and other psychological ills.

27 Jan 2011

U.S. FDA announces link between breast implants and ALCL

The U.S. Food and Drug Administration today announced a possible association between saline and silicone gel-filled breast implants and anaplastic large cell lymphoma, a very rare type of cancer.

27 Jan 2011

ASPS, FDA collaborate to establish national breast implant registry

The American Society of Plastic Surgeons (ASPS) is establishing a national registry for breast implants in collaboration with the Food and Drug Administration (FDA). The registry is being developed in response to reports of a rare lymphoma--Anaplastic Large Cell Lymphoma (ALCL)—in a very small number of women with breast implants.

27 Jan 2011

Cell News and Research

Receptos begins RPC1063 Phase 1 clinical study in patients with multiple sclerosis

Aging-associated protein deficiency may lead to positive breast cancer in women

Iniparib Phase III study in metastatic triple-negative breast cancer does not meet primary goal

Cardiac stem cell therapy can rebuild damaged heart in children

Provectus announces completion of PV-10 Phase 1 trial in patients with liver cancer

Interferon-alpha associated with increased risk of atherosclerosis in patients with SLE

St. Michael's Hospital to build first automated high-throughput zebrafish screening facility in Canada

As recording technology rapidly improves, neurons give up their secrets cell by cell

Scientists discover new mechanism neurons use to fine-tune electrical output

ASAPS supports new national registry for breast implants

Fibroblasts help 'recruit' immune cells for tumor growth

'Phenotype switching' helps bacteria lie dormant inside host cells and become a reservoir for relapsing infections

First three-dimensional projectome map of intact brain

Molecular mechanism in nerve fibers ensures rapid conductance of nervous system impulses

AB Science initiates recruitment in masitinib phase 3 study in severe persistent asthma

How estrogen decreases risk and delays onset and progression of Alzheimer's disease

Study: Removal of B lymphocytes can reverse aging process

Teen brains react with erratic excitement during reward-driven tasks

U.S. FDA announces link between breast implants and ALCL

ASPS, FDA collaborate to establish national breast implant registry

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