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Mayo Clinic study finds that chromosomal rearrangements can help trace lineage of lung cancer

A diagnostic test based on chromosomal rearrangements can trace the lineage of lung cancer to determine whether two separate lung cancers in the same patient are independent tumors or a tumor that has spread to another region of the lung, a Mayo Clinic study has found. For patients with multiple tumors, that distinction could mean the difference between early stage cancer that may be cured by surgery and incurable late-stage disease.

12 Nov 2014

Hospice care lowers hospitalization, ICU admissions and invasive procedures for Medicare patients

Medicare patients with poor prognosis cancers who received hospice care had significantly lower rates of hospitalization, intensive care unit (ICU) admissions and invasive procedures at the end of life, along with significantly lower health care expenditures during the last year of life, according to a study in the November 12 issue of JAMA.

12 Nov 2014

Study reports anti-cancer activity in mice treated with experimental drug TAK-733

A University of Colorado Cancer Center study published online this week in the journal Molecular Cancer Therapeutics reports anti-cancer activity in 10 out of 11 patient tumor samples grown in mice and treated with the experimental drug TAK-733, a small molecule inhibitor of MEK1/2.

12 Nov 2014

Study: Heart attack, stroke survivors' physical limitations rapidly increase over decade

A record number of people are surviving heart attacks and stroke but those who do may experience a sharp decline in physical abilities that steadily accelerates over time, according to a new nationally-representative study led by the University of Michigan.

12 Nov 2014

Researchers identify key protein that can reduce severity of disease equivalent to MS in mice

In multiple sclerosis, the immune system goes rogue, improperly attacking the body's own central nervous system. Mobility problems and cognitive impairments may arise as the nerve cells become damaged.

12 Nov 2014

New findings could help develop therapeutic options for glycogen storage disease

Glycogen storage disorders, which affect the body's ability to process sugar and store energy, are rare metabolic conditions that frequently manifest in the first years of life. Often accompanied by liver and muscle disease, this inability to process and store glucose can have many different causes, and can be difficult to diagnose.

11 Nov 2014

Breakthrough study shows novel molecular imaging drug to detect early prostate cancer

A novel study demonstrates the potential of a novel molecular imaging drug to detect and visualize early prostate cancer in soft tissue, lymph nodes and bone. The research, published in the November issue of the Journal of Nuclear Medicine, compares the biodistribution and tumor uptake kinetics of two Tc-99m labeled ligands, MIP-1404 and MIP-1405, used with SPECT and planar imaging.

11 Nov 2014

UCSD researchers implicate new gene in idiopathic or non-syndromic autism

With the help of mouse models, induced pluripotent stem cells (iPSCs) and the "tooth fairy," researchers at the University of California, San Diego School of Medicine have implicated a new gene in idiopathic or non-syndromic autism. The gene is associated with Rett syndrome, a syndromic form of autism, suggesting that different types of autism spectrum disorder (ASD) may share similar molecular pathways.

11 Nov 2014

Stockholm researchers discover new mechanism that stimulates glucose uptake in brown fat

Research findings that can likely be used to develop a new type of medicine for type 2 diabetes are published today in the Journal of Cell Biology. Researchers at Stockholm University have discovered a new mechanism that stimulates glucose uptake in brown fat - a tissue whose primary function is to generate heat by burning fat and sugar.

11 Nov 2014

New program aims to educate COPD patients on how to manage their disease

The American Thoracic Society today announced a new program, produced with support from Sunovion Pharmaceuticals Inc., to provide materials to educate patients with chronic obstructive pulmonary disease (COPD) about this progressive lung disease and how it can be managed.

11 Nov 2014

Researchers refine diagnostic tools to predict treatment outcomes for children with neuroblastoma

Oncology researchers studying gene mutations in the childhood cancer neuroblastoma are refining their diagnostic tools to predict which patients are more likely to respond to drugs called ALK inhibitors that target such mutations. Removing some of the guesswork in diagnosis and treatment, the researchers say, may lead to more successful outcomes for children with this often-deadly cancer.

11 Nov 2014

Sulindac drug can protect against oxidative damage due to AMD

While oxygen is essential to our planet's life force and the way we function and stay healthy, high concentrations referred to as oxidative stress may very well be the cause of more than 70 widely-spread diseases such as cancer, heart disease, neurodegenerative diseases, and eye diseases including macular degeneration.

11 Nov 2014

Lung cancer screening in NLST meets standard for cost effectiveness

Dartmouth researchers say lung cancer screening in the National Lung Screening Trial (NLST) meets a commonly accepted standard for cost effectiveness as reported in the Nov. 6 issue of the New England Journal of Medicine. This relatively new screening test uses annual low-dose CT scans to spot lung tumors early in individuals facing the highest risks of lung cancer due to age and smoking history.

11 Nov 2014

Two new oral medications post-transplant is safe, beneficial for patients with hepatitis C

All patients with hepatitis C who receive a liver transplant will eventually infect their new livers. These transplanted organs then require anti-viral treatment before they become severely damaged. But traditional post-transplant hepatitis C therapy can take up to a year, is potentially toxic and can lead to organ rejection.

11 Nov 2014

Innovative program benefits incapacitated patients with no family or friends

A Regenstrief Institute and Eskenazi Health study reports on an innovative program that trains and supervises volunteers who act as advocates for adults and seniors who are unable to make their own decisions due to conditions like Alzheimer's disease or coma, but have no family or friends to help them.

11 Nov 2014

UW SMPH awarded $70 million grant to continue work on Inner-City Asthma Consortium

The National Institute of Allergy and Infectious Diseases, part of the National Institutes of Health, has awarded the University of Wisconsin School of Medicine and Public Health a seven-year, $70 million grant for its continuing work on the Inner-City Asthma Consortium (ICAC) -- a nationwide clinical research network to evaluate and develop promising new immune-based treatments.

11 Nov 2014

New study finds that it is possible to distinguish between different hemorrhagic fevers

A new study has found it is possible to distinguish between different hemorrhagic fevers, including Marburg (Ebola cousin) and Lassa before the person becomes symptomatic.

11 Nov 2014

Study points to major role of obesity in triggering, prolonging autoimmune diseases

Autoimmune diseases like Crohn's Disease and multiple sclerosis, in which the immune system attacks its own body rather than predatory invaders, affect 5-20% of the global community. A study published recently in Autoimmunity Reviews by Prof. Yehuda Shoenfeld, the Laura Schwarz-Kipp Chair for Research of Autoimmune Diseases at Tel Aviv University's Sackler Faculty of Medicine and Head of Zabludowicz Center for Autoimmune Diseases at Chaim Sheba Medical Center, Tel Hashomer, points to the major role obesity plays in triggering and prolonging these autoimmune diseases.

11 Nov 2014

Patients who receive care from nurses with bachelor's degrees have shorter stays, fewer readmissions

Patients in an eastern academic medical center who received most of their nursing care from nurses with bachelor of science degrees had better care, fewer readmissions and shorter stays, according to a University of Michigan study.

11 Nov 2014

Researchers explain interaction between HNRNPA2B1 protein and pancreatic cancer development

Researchers from the University of Barcelona have described an interaction between the protein HNRNPA2B1 and pancreatic cancer development which remained unknown. The study, published in the journal Gastroenterology, has proved in human cancer cell lines that this protein is essential to the correct activity of the oncogenic protein KRAS, related to cancer start and development.

11 Nov 2014

Medicine News and Research

Mayo Clinic study finds that chromosomal rearrangements can help trace lineage of lung cancer

Hospice care lowers hospitalization, ICU admissions and invasive procedures for Medicare patients

Study reports anti-cancer activity in mice treated with experimental drug TAK-733

Study: Heart attack, stroke survivors' physical limitations rapidly increase over decade

Researchers identify key protein that can reduce severity of disease equivalent to MS in mice

New findings could help develop therapeutic options for glycogen storage disease

Breakthrough study shows novel molecular imaging drug to detect early prostate cancer

UCSD researchers implicate new gene in idiopathic or non-syndromic autism

Stockholm researchers discover new mechanism that stimulates glucose uptake in brown fat

New program aims to educate COPD patients on how to manage their disease

Researchers refine diagnostic tools to predict treatment outcomes for children with neuroblastoma

Sulindac drug can protect against oxidative damage due to AMD

Lung cancer screening in NLST meets standard for cost effectiveness

Two new oral medications post-transplant is safe, beneficial for patients with hepatitis C

Innovative program benefits incapacitated patients with no family or friends

UW SMPH awarded $70 million grant to continue work on Inner-City Asthma Consortium

New study finds that it is possible to distinguish between different hemorrhagic fevers

Study points to major role of obesity in triggering, prolonging autoimmune diseases

Patients who receive care from nurses with bachelor's degrees have shorter stays, fewer readmissions

Researchers explain interaction between HNRNPA2B1 protein and pancreatic cancer development

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