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Human model of rare genetic disease reveals new clues to aging process

Scientists from A*STAR's Institute of Medical Biology (IMB) in Singapore and the University of Hong Kong's Department of Medicine have produced the world's first human cell model of progeria, a disease resulting in severe premature ageing in one in four to eight million children worldwide. This model has allowed them to make new discoveries concerning the mechanism by which progeria works.

25 Jan 2011

Researchers design engineered organ study the use of nanoparticles in breast cancer detection

Purdue University researchers have reproduced portions of the female breast in a tiny slide-sized model dubbed "breast on-a-chip" that will be used to test nanomedical approaches for the detection and treatment of breast cancer.

25 Jan 2011

New investigative tool may explore intracellular processes with unprecedented clarity

Nongjian Tao and his colleagues at the Biodesign Institute at Arizona State University have pioneered a new technique capable of peering into single cells and even intracellular processes with unprecedented clarity.

25 Jan 2011

New research reveals dynamics behind signal transmission in brain

Surprising rate at which neuronal networks in the cerebral cortex delete sensory information. The dynamics behind signal transmission in the brain are extremely chaotic. This conclusion has been reached by scientists from the Max Planck Institute for Dynamics and Self-Organization at the University of Göttingen and the Bernstein Center for Computational Neuroscience Göttingen.

24 Jan 2011

Bax factor that promotes cell death is also involved in regulating mitochondria behavior

New research led by UC Davis scientists provides insight into why some body organs are more susceptible to cell death than others and could eventually lead to advances in treating or preventing heart attack or stroke.

24 Jan 2011

New study shows biomarker test can aid in early, precise diagnosis of melanoma

A new study shows that a test of biomarkers for DNA methylation is technically feasible and could aid in earlier, more precise diagnosis of melanoma.

24 Jan 2011

Fat grafting safety review published; no increased risk of cancer

Published clinical experience in over 2,000 patients who received autologous fat grafts showed no evidence of increased risk of development, metastasis or recurrence of breast cancer in contrast to laboratory data.

24 Jan 2011

Biomerix receives CE Mark approval for REVIVE soft tissue repair mesh

Biomerix Corporation announced today that it has received CE Mark approval for its REVIVE™ soft tissue repair mesh allowing for the marketing of REVIVE in all European Union member (EU) states. REVIVE received 510(k) clearance from the U.S. Food and Drug Administration (FDA) in January 2009.

24 Jan 2011

ArQule's ARQ 197 Phase 1 clinical trial results in colorectal cancer presented at ASCO 2011

ArQule, Inc. today announced the presentation of Phase 1 results of a clinical trial among patients with metastatic colorectal cancer (CRC) treated with ARQ 197, a selective small molecule inhibitor of the c-MET receptor tyrosine kinase, in combination with irinotecan and cetuximab. ARQ 197 is under development by Daiichi Sankyo Co., Ltd. and ArQule.

24 Jan 2011

Senesco files SNS01-T IND for treatment of multiple myeloma

Senesco Technologies, Inc. today announced that the Company has filed an Investigational New Drug application with the U.S. Food and Drug Administration for Senesco's lead drug candidate SNS01-T for treatment of multiple myeloma.

24 Jan 2011

Boston Scientific completes enrollment in comparison trial of SYNERGY Stent to PROMUS Element Stent

Boston Scientific Corporation today announced the completion of patient enrollment in the EVOLVE clinical trial, which is designed to assess the safety and performance of the Company's fourth-generation SYNERGY™ Coronary Stent. The randomized, single-blind, non-inferiority trial will compare the SYNERGY Stent to the PROMUS Element™ Everolimus-Eluting Coronary Stent in patients with a single de novo native coronary artery lesion.

24 Jan 2011

Agenus enters research agreement with Memorial Sloan-Kettering Cancer Center

Agenus Inc. today announced it has entered into a research agreement with Memorial Sloan-Kettering Cancer Center (MSKCC) using Agenus' proprietary cancer vaccine technology.

24 Jan 2011

Spectrum submits Post Approval Supplement for removal of bioscan requirement for Indium-111 ZEVALIN

Spectrum Pharmaceuticals, a biotechnology company with fully integrated commercial and drug development operations with a primary focus in oncology, today announced that on Thursday, January 20, 2011, it submitted a Post Approval Supplement containing data supporting the removal of the Indium-111 ZEVALIN® pre-treatment imaging evaluation, more commonly referred to as the "bioscan" requirement.

24 Jan 2011

Rogue gene blocked by right drugs could stop cancer

Scientists at the University of East Anglia (UEA) have discovered a rogue gene which - if blocked by the right drugs - could stop cancer in its tracks.

24 Jan 2011

Breakthrough in understanding mechanisms behind hereditary alpha-1-antitrypsin deficiency

Researchers from the Royal College of Surgeons in Ireland (RCSI) and Beaumont Hospital have made a breakthrough in understanding the mechanisms behind the most severe form of hereditary emphysema and how protein treatments can improve the condition. The findings of this study may also lead to new treatments for patients with smoker's emphysema.

24 Jan 2011

Northwest Biotherapeutics resumes enrollment in DCVax Phase II clinical trial for GBM brain cancer

Northwest Biotherapeutics announced today that the Company is resuming enrollment of additional new patients into its ongoing 240-patient, double blind, randomized, placebo controlled Phase II clinical trial of DCVax for Glioblastoma multiforme brain cancer.

24 Jan 2011

AnC Bio Holdings invests $4 million in Bioheart

Bioheart, Inc. announced today that it has entered into an agreement with AnC Bio Holdings, Inc., a South Korean biomedical company, and one of its U.S. agents for a $4 million equity investment. Bioheart has designated proceeds from the investment to advance the current clinical evaluation of its cell therapies for treating heart failure and related cardiac diseases.

24 Jan 2011

Exiqon launches new Hi-Power microRNA labeling kits

Exiqon, a leading supplier of high-value gene expression analysis products, today announced the launch of the 3rd generation of miRCURY LNA microRNA Labeling Kit called Hi-Power for labeling of microRNAs for downstream hybridization to microRNA arrays.

24 Jan 2011

Raptor completes enrollment in DR Cysteamine Phase 3 clinical trial in cystinosis

Raptor Pharmaceutical Corp., today announced it has completed enrollment in its Phase 3 clinical trial of its proprietary delayed-release oral formulation of cysteamine bitartrate ("DR Cysteamine") in patients with nephropathic cystinosis ("cystinosis").

24 Jan 2011

Elsevier, Robert Koch Institute partner for systematic posting of manuscripts in institutional repositories

Elsevier, the world-leading publisher of scientific, technical and medical information products and services, and the Robert Koch Institute announced they have entered into a two-year trial agreement enabling researchers at Robert Koch Institute to systematically post their manuscripts in the institutional repository.

24 Jan 2011

Cell News and Research

Human model of rare genetic disease reveals new clues to aging process

Researchers design engineered organ study the use of nanoparticles in breast cancer detection

New investigative tool may explore intracellular processes with unprecedented clarity

New research reveals dynamics behind signal transmission in brain

Bax factor that promotes cell death is also involved in regulating mitochondria behavior

New study shows biomarker test can aid in early, precise diagnosis of melanoma

Fat grafting safety review published; no increased risk of cancer

Biomerix receives CE Mark approval for REVIVE soft tissue repair mesh

ArQule's ARQ 197 Phase 1 clinical trial results in colorectal cancer presented at ASCO 2011

Senesco files SNS01-T IND for treatment of multiple myeloma

Boston Scientific completes enrollment in comparison trial of SYNERGY Stent to PROMUS Element Stent

Agenus enters research agreement with Memorial Sloan-Kettering Cancer Center

Spectrum submits Post Approval Supplement for removal of bioscan requirement for Indium-111 ZEVALIN

Rogue gene blocked by right drugs could stop cancer

Breakthrough in understanding mechanisms behind hereditary alpha-1-antitrypsin deficiency

Northwest Biotherapeutics resumes enrollment in DCVax Phase II clinical trial for GBM brain cancer

AnC Bio Holdings invests $4 million in Bioheart

Exiqon launches new Hi-Power microRNA labeling kits

Raptor completes enrollment in DR Cysteamine Phase 3 clinical trial in cystinosis

Elsevier, Robert Koch Institute partner for systematic posting of manuscripts in institutional repositories

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