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Study may help develop novel ways to combat lipotoxic cardiomyopathy, related heart disease

A team led by Rolf Bodmer, Ph.D. at Sanford-Burnham Medical Research Institute recently unraveled an alternative pathway to lipotoxic cardiomyopathy in fruit flies - a genetic mechanism that occurs independently of a diet high in fat.

19 Jan 2011

MicroRNA-29 molecule makes brain cells resistant to programmed cell death

Researchers at the University of North Carolina at Chapel Hill have discovered a molecule that can make brain cells resistant to programmed cell death or apoptosis.

19 Jan 2011

Postmenopausal women receiving estrogen plus progestin at increased risk of breast cancer

Researchers have identified how the hormones progesterone and estrogen interact to increase cell growth in normal mammary cells and mammary cancers, a novel finding that may explain why postmenopausal women receiving hormone replacement therapy with estrogen plus progestin are at increased risk of breast cancer.

19 Jan 2011

AMBR sensor measures growth and drug susceptibility of bacterial cells without use of microscope

With an invention that can be made from some of the same parts used in CD players, University of Michigan researchers have developed a way to measure the growth and drug susceptibility of individual bacterial cells without the use of a microscope.

19 Jan 2011

Research provides new insight into how HIV protein's structural changes may alter viral infection into healthy cells

The UK's National Physical Laboratory with the University of Edinburgh and IBM's TJ Watson Research Center have published new research about the structure of an HIV-1 protein that could help to develop new drugs to stop the virus infecting healthy cells.

19 Jan 2011

UQAM student identifies gene linked to B-cell acute lymphocytic leukemia

Cyndia Charfi, a Ph. D student in biology at Universit- du Qu-bec - Montr-al (UQAM), supported by her thesis supervisors, Professor -ric Rassart, and Adjunct Professor Elsy Edouard, UQAM, Department of Biological Sciences and BIOMED Research Centre, made a major breakthrough in research on B-cell acute lymphocytic leukemia, a disease that occurs most commonly in children.

19 Jan 2011

UMMS begins MBL-HCV1 Phase 2 trial to prevent hepatitis C virus infection in liver transplant patients

Following a successful Phase 1 study for safety, researchers at MassBiologics of the University of Massachusetts Medical School today announced the beginning of a Phase 2 clinical trial testing the ability of a human monoclonal antibody they developed to prevent hepatitis C virus infection of a donor liver in transplant patients.

19 Jan 2011

Boehringer Ingelheim to acquire Amgen's Fremont California development and manufacturing facility

Amgen Inc. and Boehringer Ingelheim today announced they have signed an agreement under which Boehringer Ingelheim will acquire Amgen's rights in and substantially all assets at Amgen's Fremont California development and manufacturing facility.

19 Jan 2011

Study highlights lack of treatment for adolescents with severe mental disorders

A recent study by Merikangas and colleagues published in the January 2011 issue of the Journal of the American Academy of Child and Adolescent Psychiatry shows that only half of adolescents that are affected with severely impairing mental disorders ever receive treatment for their disorders.

19 Jan 2011

Celulas Genetica, EHRI enter joint venture to pursue testing of Rutherford Procedure using NASA bioreactor

Emerging Healthcare Solutions, announced today that it has entered into a joint venture agreement with its wholly owned subsidiary, Celulas Genetica, in order to pursue testing of the revolutionary Rutherford Procedure using a NASA bioreactor.

19 Jan 2011

Harbor Biosciences signs development agreements for HE2000, HE3235 and HE3286 with CIPI

Harbor BioSciences, Inc., a leader in the development of a proprietary class of adrenal steroid hormones as novel pharmaceuticals, announced it has licensed the research and development and commercialization rights for three of its products, exclusively in the People's Republic of China and Hong Kong, to China State Institute of Pharmaceutical Industry (CIPI).

18 Jan 2011

New data on role of miR-34 tumor suppressor in preventing cancer stem cell development

Mirna Therapeutics, Inc., a leading developer of microRNA (miRNA)-based therapeutics, announced today the publication of new data in the journal Nature Medicine describing the role of the tumor suppressor miRNA, miR-34, in preventing cancer stem cell development. The published results reveal that miR-34 is commonly down-regulated in prostate cancer stem cells and that this down-regulation is essential for cancer stem cell viability.

18 Jan 2011

Quebec reimburses VIDAZA for treatment of blood cancer

Quebec patients with serious blood cancers (intermediate-2 and high-risk myelodysplastic syndrome and acute myeloid leukemia) now have publicly funded access to a new innovative therapy, VIDAZA® (azacitidine). Following a priority review and subsequent positive recommendation from the Conseil du medicament, patients now have the potential to significantly extend survival.

18 Jan 2011

'Master switch' protein in white blood cells linked to inflammation

Scientists have identified a protein that acts as a "master switch" in certain white blood cells, determining whether they promote or inhibit inflammation. The study, published in the journal Nature Immunology, could help researchers look for new treatments for diseases such as rheumatoid arthritis that involve excessive inflammation.

18 Jan 2011

Vaccine to prevent MRSA infections after bone and joint surgery

University of Rochester Medical Center orthopaedic scientists are a step closer to developing a vaccine to prevent life-threatening methicillin-resistant staphylococcus aureus (MRSA) infections following bone and joint surgery.

18 Jan 2011

Heart disease patients' skin cells may help test long QT syndrome

Skin cells from a patient with an inherited heart disease were the seeds of a stem cell experiment that could help researchers test specific treatments for the disease, known as long QT syndrome. The research results appear in the January 16 issue of the journal Nature.

18 Jan 2011

Clinical studies by expert HIV clinicians suggest that HIV-TRePS may have clinical and economic benefits

Two multinational clinical studies indicate that the RDI’s system for predicting how HIV and AIDS patients will respond to different drugs could be a useful tool with potential clinical and economic benefits. The studies, published in the January issue of AIDS Patient Care and STDs, involved highly experienced physicians in the USA, Canada and Italy who used the system to help them select the optimum combination of HIV drugs for patients whose therapy was failing.

18 Jan 2011

OMJPI, Sanford-Burnham enter agreement to discover compounds for Alzheimer's disease, psychiatric disorders

Sanford-Burnham Medical Research Institute has entered into a collaboration with Ortho-McNeil-Janssen Pharmaceuticals, Inc., to discover compounds for Alzheimer's disease and major psychiatric disorders.

18 Jan 2011

75% of cell plasma membrane reversibly endocytosed

In three papers in the January and February issues of the Journal of General Physiology, Don Hilgemann and colleagues have extensively characterized a previously unidentified process by which up to 75% of the cell plasma membrane can be reversibly endocytosed.

18 Jan 2011

T3SS-dependent bacteria may be a suitable point of attack for future antibiotics: Study

So-called type-3 secretion systems of pathogenic bacteria may be a suitable point of attack for future antibiotics. This is shown by Professor Maria Fällman and her associates at Umeå University in Sweden in the Proceeding of the National Academy of Sciences, PNAS, in the US.

18 Jan 2011

Cell News and Research

Study may help develop novel ways to combat lipotoxic cardiomyopathy, related heart disease

MicroRNA-29 molecule makes brain cells resistant to programmed cell death

Postmenopausal women receiving estrogen plus progestin at increased risk of breast cancer

AMBR sensor measures growth and drug susceptibility of bacterial cells without use of microscope

Research provides new insight into how HIV protein's structural changes may alter viral infection into healthy cells

UQAM student identifies gene linked to B-cell acute lymphocytic leukemia

UMMS begins MBL-HCV1 Phase 2 trial to prevent hepatitis C virus infection in liver transplant patients

Boehringer Ingelheim to acquire Amgen's Fremont California development and manufacturing facility

Study highlights lack of treatment for adolescents with severe mental disorders

Celulas Genetica, EHRI enter joint venture to pursue testing of Rutherford Procedure using NASA bioreactor

Harbor Biosciences signs development agreements for HE2000, HE3235 and HE3286 with CIPI

New data on role of miR-34 tumor suppressor in preventing cancer stem cell development

Quebec reimburses VIDAZA for treatment of blood cancer

'Master switch' protein in white blood cells linked to inflammation

Vaccine to prevent MRSA infections after bone and joint surgery

Heart disease patients' skin cells may help test long QT syndrome

Clinical studies by expert HIV clinicians suggest that HIV-TRePS may have clinical and economic benefits

OMJPI, Sanford-Burnham enter agreement to discover compounds for Alzheimer's disease, psychiatric disorders

75% of cell plasma membrane reversibly endocytosed

T3SS-dependent bacteria may be a suitable point of attack for future antibiotics: Study

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