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Pediatric Trauma Program launches holiday PSA against hazards of texting while driving

The Pediatric Trauma Program at Children's Hospital Los Angeles is launching a holiday public service announcement focusing on the hazards of texting while driving in an effort to reduce injuries and death across the Southland.

24 Dec 2010

$1.1 billion Martek sale measures success of UMD-Mtech 'grads'

The latest success of Martek Biosciences, a rising-star among Maryland biotechs, began more than a decade ago in a plain, brick building on the University of Maryland campus. With a good idea and early-stage nurturing from the university's Maryland Technology Enterprise Institute (Mtech), the company has been able to grow into a major international business.

24 Dec 2010

Gold-coated liposomes could make chemotherapy more effective without harmful side effects

University of Arizona researchers may have found a way to deliver chemotherapeutic drugs to cancer tissues in controlled doses without harming healthy body cells.

24 Dec 2010

New derivation of stem cells from fat cells hold promise for therapeutic, cosmetic benefits

Two studies appearing in the current issue of Cell Transplantation 19(10) discuss stem cells derived from adipose (fat) cells and their potential use in plastic surgery and tissue reconstruction. The studies are now freely available on-line at http://www.ingentaconnect.com/content/cog/ct/ .

24 Dec 2010

AMPK activates autophagy by activating ATG1 enzyme

Researchers at the Salk Institute for Biological Studies have discovered how AMPK, a metabolic master switch that springs into gear when cells run low on energy, revs up a cellular recycling program to free up essential molecular building blocks in times of need.

24 Dec 2010

Quercetin and resveratrol may play an important role in inflammation and insulin resistance

A study was carried out to examine the extent to which quercetin and trans-resveratrol (RSV) prevented inflammation or insulin resistance in primary cultures of human adipocytes treated with tumor necrosis factor-a (TNF-a)-an inflammatory cytokine elevated in the plasma and adipose tissue of obese, diabetic individuals. Cultures of human adipocytes were pretreated with quercetin and trans-RSV followed by treatment with TNF-a. Subsequently, gene and protein markers of inflammation and insulin resistance were measured.

24 Dec 2010

China emerging as world leader in stem-cell R&D

Recent breakthroughs show that China is emerging as a world leader in stem-cell research and development, says Emerging Healthcare Solutions President and CEO Cindy Morrissey.

24 Dec 2010

Molecular-level insights into how physical activity influences the heart

Everyone knows that exercise comes with metabolic and cardiovascular benefits, but scientists understand surprisingly little about how physical activity influences the heart itself. Now, a new study in the December 23rd issue of Cell, a Cell Press publication, offers some of the first molecular-level insights.

24 Dec 2010

Scientists tweak gene to mimick heart-strengthening effects of endurance training in sedentary mice

By tweaking a single gene, scientists have mimicked in sedentary mice the heart-strengthening effects of two weeks of endurance training, according to a report from Dana-Farber Cancer Institute and Beth Israel Deaconess Medical Center (BIDMC).

24 Dec 2010

Sequestering GSK3 enzyme leads to stabilization of proteins in cells

The cell signaling pathway known as Wnt, commonly activated in cancers, causes internal membranes within a healthy cell to imprison an enzyme that is vital in degrading proteins, preventing the enzyme from doing its job and affecting the stability of many proteins within the cell, researchers at UCLA's Jonsson Comprehensive Cancer Center have found.

24 Dec 2010

Silencing of specific genes of germinal cell lines reduces brain tumors

Scientists at IRB Barcelona have discovered that some brain tumours in larvae of the fruit fly Drosophila melanogaster use the genetic programme of germline cells to grow. The removal of some of these genes leads to healthy brains. This finding demonstrates that these genes are crucial for tumour development. The study, headed by ICREA researcher Cayetano Gonz-lez, is published today in the prestigious journal Science.

24 Dec 2010

YM Biosciences underwriters exercise Over-Allotment Option in full

YM BioSciences Inc. announced today that, in connection with its previously announced public offering for total net proceeds before expenses of US $37,650,000, the underwriters have exercised in full their Over-Allotment Option to purchase an additional 3,750,000 common shares of YM at US $1.60 per share for additional net proceeds of US $5,665,000.

24 Dec 2010

Paternal diet affects lipid metabolizing genes in offspring

Scientists at the University of Massachusetts Medical School and the University of Texas at Austin have uncovered evidence that environmental influences experienced by a father can be passed down to the next generation, "reprogramming" how genes function in offspring. A new study published this week in Cell shows that environmental cues-in this case, diet-influence genes in mammals from one generation to the next, evidence that until now has been sparse.

24 Dec 2010

Researchers study relationship between MITF, ATF2 in melanoma development

Melanoma is one of the least common types of skin cancer, but it is also the most deadly. Melanocytes (pigment-producing skin cells) lose the genetic regulatory mechanisms that normally limit their number, allowing them to divide and proliferate out of control. One such regulator, called MITF, controls an array of genes that influence melanocyte development, function and survival.

24 Dec 2010

Target enrollment reached in belinostat Phase 2 study in Carcinoma of Unknown Primary

Spectrum Pharmaceuticals, a biotechnology company with fully integrated commercial and drug development operations with a primary focus in oncology, announced today that the target enrollment has been reached for the Phase 2 study of belinostat in Carcinoma of Unknown Primary (CUP).

23 Dec 2010

Scientists pinpoint brain site where leptin hormone may trigger onset of puberty

UT Southwestern Medical Center researchers have pinpointed a tiny site in the brain where the hormone leptin may help trigger the onset of puberty.

23 Dec 2010

Past experiences subconsciously influence behavior: Researchers

Researchers at MIT's Picower Institute for Learning and Memory report for the first time how animals' knowledge obtained through past experiences can subconsciously influence their behavior in new situations.

23 Dec 2010

Jury returns $7M verdict for failure to diagnose and treat cardiac tamponade in bypass surgery patient

A New York State Supreme Court Queens County jury returned a $7,000,000.00 verdict against Patrick Monteleone M.D. and Newell Robinson, M.D. where they failed to diagnose and treat cardiac tamponade (bleeding into the chest) in their patient who underwent cardiac bypass surgery on November 17, 2004.

23 Dec 2010

EMCTO 2011 to provide update on treatment of thoracic malignancies

The number of diagnostic and therapeutic options for patients with thoracic malignancies has markedly increased, allowing for an individualized approach based on the clinical situation and molecular characteristics of the tumor. How to best select among these options for the benefit of the patients within an integrative treatment approach will be at the core of the conference.

23 Dec 2010

Catalogs of fruit fly and roundworm's functional genomic elements

Scientists today published catalogs of the fruit fly and roundworm's functional genomic elements: DNA sequences in the genome that carry the instructions and determine which genes are turned on and off at various times in different cells.

23 Dec 2010

Cell News and Research

Pediatric Trauma Program launches holiday PSA against hazards of texting while driving

$1.1 billion Martek sale measures success of UMD-Mtech 'grads'

Gold-coated liposomes could make chemotherapy more effective without harmful side effects

New derivation of stem cells from fat cells hold promise for therapeutic, cosmetic benefits

AMPK activates autophagy by activating ATG1 enzyme

Quercetin and resveratrol may play an important role in inflammation and insulin resistance

China emerging as world leader in stem-cell R&D

Molecular-level insights into how physical activity influences the heart

Scientists tweak gene to mimick heart-strengthening effects of endurance training in sedentary mice

Sequestering GSK3 enzyme leads to stabilization of proteins in cells

Silencing of specific genes of germinal cell lines reduces brain tumors

YM Biosciences underwriters exercise Over-Allotment Option in full

Paternal diet affects lipid metabolizing genes in offspring

Researchers study relationship between MITF, ATF2 in melanoma development

Target enrollment reached in belinostat Phase 2 study in Carcinoma of Unknown Primary

Scientists pinpoint brain site where leptin hormone may trigger onset of puberty

Past experiences subconsciously influence behavior: Researchers

Jury returns $7M verdict for failure to diagnose and treat cardiac tamponade in bypass surgery patient

EMCTO 2011 to provide update on treatment of thoracic malignancies

Catalogs of fruit fly and roundworm's functional genomic elements

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