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Elsevier provides four key electronic textbook titles for UCI School of Medicine

Elsevier, a world-leading publisher of scientific, technical and medical information products and services, announced today it will provide four key electronic textbook titles for UC Irvine School of Medicine's new program that gives Apple iPads to its first-year medical students.

26 Aug 2010

Motor proteins play critical role in stabilization of long-term memories

Functioning much like gears in a machine, cellular motor proteins are critical to dynamic functions throughout the body, including muscle contraction, cell migration and cellular growth processes. Now, neuroscientists from UC Irvine and the Florida campus of The Scripps Research Institute report that motor proteins also play a critical role in the stabilization of long-term memories. The findings add an unexpected dimension to the story of how memories are encoded and suggest new targets for therapeutic interventions.

26 Aug 2010

Researchers show biosynthetic cornea can stimulate regeneration in damaged eye tissue

A new study from researchers in Canada and Sweden has shown that biosynthetic corneas can help regenerate and repair damaged eye tissue and improve vision in humans.

26 Aug 2010

Data from PLX4032 Phase 1 clinical trial in melanoma patients with BRAF mutation published

Plexxikon today announced publication of data from the Phase 1 clinical trial of PLX4032 (RG7204), confirming that treatment of metastatic melanoma patients with the BRAF V600E mutation resulted in significant tumor shrinkage in the majority of patients. Specifically, in the melanoma extension cohort of the study, nearly all patients showed some response; 81 percent of patients had tumor shrinkage of at least 30 percent.

26 Aug 2010

Treating metastatic melanoma tumors with specific genetic signature shows promising results

Use of an experimental targeted drug to treat metastatic melanoma tumors with a specific genetic signature was successful in more than 80 percent of patients in a phase 1 clinical trial.

26 Aug 2010

Researchers develop magnetic nanoparticles for metallic implant drug delivery

If a drug can be guided to the right place in the body, the treatment is more effective and there are fewer side-effects. Researchers at Lund University in Sweden have now developed magnetic nanoparticles that can be directed to metallic implants such as artificial knee joints, hip joints and stents in the coronary arteries.

26 Aug 2010

PLX4032 therapy results in tumor shrinkage in metastatic melanoma patients

A multicenter study has concluded that treatment with a new targeted therapy called PLX4032 (also called RG7204) resulted in significant tumor shrinkage in 80 percent of patients with advanced melanoma.

26 Aug 2010

Biomoda's CyPath assay for lung cancer detection receives Canadian patent

Cancer diagnostics company Biomoda, Inc. has received a notice of allowance for a Canadian patent application for a method of using its proprietary porphyrin-based compound that binds to cancer cells and causes them to fluoresce under specific frequencies of light when viewed under a fluorescent microscope.

26 Aug 2010

Critical mechanistic link between mutant protein and disease pathogenesis in ALS uncovered

New research uncovers what may be a primary neuron-damaging insult that occurs in an inherited form of a devastating neurodegenerative disorder. The study, published by Cell Press in the August 26th issue of the journal Neuron, describes a critical mechanistic link between a mutant protein and disease pathogenesis in an animal model of amyotrophic lateral sclerosis (ALS).

26 Aug 2010

NIH suspends funding new embryonic stem cell research following court order

"The National Institutes of Health announced Tuesday that it has suspended funding new human embryonic stem cell research and that all federally funded experiments already underway will be cut off when they come up for renewal if a new court order is not overturned. The announcement -- which confirmed fears among proponents that the ruling would result in a comprehensive freeze in federal support for stem cell research -- came in response to a court order Monday barring the government from funding the research because it involves the destruction of embryos.

26 Aug 2010

Neuralstem files IND with FDA for spinal cord stem cell Phase I clinical trial for chronic spinal cord injury

Neuralstem, Inc. announced that it has filed an Investigational New Drug (IND) application with the United States Food and Drug Administration (FDA) to begin a Phase I safety clinical trial for chronic spinal cord injury with its spinal cord stem cells. This multicenter Phase I safety trial will enroll a total of 16 long-term, or chronic, spinal cord injury patients, with an American Spinal Injury Association (ASIA) Grade A level of impairment, one-to-two years post-injury.

26 Aug 2010

Developing specific liver cell lines from stem cells holds promise for new liver disease treatment: Researchers

By creating diseased liver cells from a small sample of human skin, scientists have for the first time shown that stem cells can be used to model a diverse range of inherited disorders. The University of Cambridge researchers' findings, which will hopefully lead to new treatments for those suffering from liver diseases, were published today in The Journal of Clinical Investigation.

26 Aug 2010

FDA grants LFB's recombinant anti-CD20 monoclonal antibody orphan drug status for CLL

The recombinant anti-CD20 monoclonal antibody produced by LFB Biotechnologies received orphan drug status for the treatment of Chronic Lymphocytic Leukemia (CLL). This approval from the FDA Office of Orphan Products Development was granted on August 6th, 2010.

26 Aug 2010

Sysmex announces 3-year sole source microscopic urinalysis contract agreement with Novation

Sysmex, a global leader in medical diagnostic testing equipment and information systems technology, today announced a three-year sole source microscopic urinalysis contract agreement with group purchasing organization Novation. Novation is the leading health care supply contracting company for more than 25,000 members of VHA Inc. and the University HealthSystem Consortium (UHC), two national health care alliances, and 5,500 members of Provista, LLC, representing 28,000 sites.

From Sysmex America, Inc. 26 Aug 2010

Study finds BPA exposure impacts endocrine changes in men

An international group of researchers led by the Peninsula Medical School and the University of Exeter have for the first time identified changes in sex hormones associated with BPA exposure in men, in a large population study. The study results are published in the latest issue of Environmental Health Perspectives.

26 Aug 2010

Scientists create novel map of lipid locations in single cell

In real estate, location is everything. The same might be said of lipids - those crucial cellular fats and oils that serve as building blocks for cells and as key energy sources for the body.In a paper published in the September issue of the Journal of Lipid Research, a team of scientists, led by researchers at the University of California, San Diego School of Medicine, has mapped for the first time the actual locations of specific lipids within a single cell.

26 Aug 2010

Study on current insect repellants confirms need for better insect repellants

Fire up the citronella-scented tiki torches, and slather on the DEET: Everybody knows these simple precautions repel insects, notably mosquitoes, whose bites not only itch and irritate, but also transmit diseases such as West Nile virus, malaria and dengue. Now, Johns Hopkins scientists have discovered what it is in the bugs' molecular makeup that enables citronellal (the aromatic liquid used in lotions, sprays and candles) and DEET, to deter insects from landing and feeding on you. A better understanding of these molecular-behavioral links already is aiding the team's search for more effective repellants.

26 Aug 2010

Ataxin 2 gene mutation contributes to Lou Gehrig's disease: Research

An international study led by biologists and neuroscientists from the University of Pennsylvania has identified a new genetic risk factor for amyotrophic lateral sclerosis, commonly known as ALS or Lou Gehrig's disease.

26 Aug 2010

3D MRI enhances visualization, displays fetal anatomy and diagnosing problems

Three-dimensional MRI is an emerging and useful technique for displaying fetal anatomy and diagnosing problems in the womb in a wide spectrum of clinical applications, according to Jeffrey C. Hellinger, M.D., a pediatric imaging specialist at Stony Brook University Medical Center.

26 Aug 2010

Research finds adenovirus impact on cell's suicide program pave way for new cancer therapy

A novel mechanism used by adenovirus to sidestep the cell's suicide program, could go a long way to explain how tumor suppressor genes are silenced in tumor cells and pave the way for a new type of targeted cancer therapy, report researchers at the Salk Institute for Biological Studies in the Aug. 26, 2010 issue of Nature.

26 Aug 2010

Cell News and Research

Elsevier provides four key electronic textbook titles for UCI School of Medicine

Motor proteins play critical role in stabilization of long-term memories

Researchers show biosynthetic cornea can stimulate regeneration in damaged eye tissue

Data from PLX4032 Phase 1 clinical trial in melanoma patients with BRAF mutation published

Treating metastatic melanoma tumors with specific genetic signature shows promising results

Researchers develop magnetic nanoparticles for metallic implant drug delivery

PLX4032 therapy results in tumor shrinkage in metastatic melanoma patients

Biomoda's CyPath assay for lung cancer detection receives Canadian patent

Critical mechanistic link between mutant protein and disease pathogenesis in ALS uncovered

NIH suspends funding new embryonic stem cell research following court order

Neuralstem files IND with FDA for spinal cord stem cell Phase I clinical trial for chronic spinal cord injury

Developing specific liver cell lines from stem cells holds promise for new liver disease treatment: Researchers

FDA grants LFB's recombinant anti-CD20 monoclonal antibody orphan drug status for CLL

Sysmex announces 3-year sole source microscopic urinalysis contract agreement with Novation

Study finds BPA exposure impacts endocrine changes in men

Scientists create novel map of lipid locations in single cell

Study on current insect repellants confirms need for better insect repellants

Ataxin 2 gene mutation contributes to Lou Gehrig's disease: Research

3D MRI enhances visualization, displays fetal anatomy and diagnosing problems

Research finds adenovirus impact on cell's suicide program pave way for new cancer therapy

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