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Scientists identify role of PNPASE in regulating RNA import into mitochondria

Researchers at UCLA's Jonsson Comprehensive Cancer Center and the departments of Chemistry and Biochemistry and Pathology and Laboratory Medicine have uncovered a role for an essential cell protein in shuttling RNA into the mitochondria, the energy-producing "power plant" of the cell. The import of nucleus-encoded small RNAs into mitochondria is essential for the replication, transcription and translation of the mitochondrial genome, but the mechanisms that deliver RNA into mitochondria remain poorly understood.

7 Aug 2010

JumpStart Ventures announces investment commitment of $250,000 in ChanRx

JumpStart Ventures, which invests in and partners with innovative, early-stage companies in Northeast Ohio, announced an investment commitment of $250,000 in drug development company ChanRx. The two-year-old company is developing a pharmaceutical compound to treat atrial fibrillation, a heart condition that affects two million Americans, with 200,000 new cases being diagnosed each year.

6 Aug 2010

Elsevier Properties congratulates Stewart for achieving Lectureship

Elsevier Properties SA is pleased to congratulate Dr. Scott Stewart on his winning the Royal Australian Chemical Institute's (RACI) 2010/11 Athel Beckwith Lectureship, sponsored by Reaxys.

6 Aug 2010

Norwegian cervical screening program begins reimbursing for liquid-based cytology

Hologic, Inc., a leading developer, manufacturer and supplier of premium diagnostics products, medical imaging systems and surgical products dedicated to serving the healthcare needs of women, today announced that on July 1, 2010, the Norwegian cervical screening program began reimbursing for liquid-based cytology (LBC).

6 Aug 2010

UC Riverside scientists secure grants for tobacco control research

Tobacco-related disease kills more people worldwide than any other single factor. To help address this problem, the University of California, Riverside has received six grants from the University of California Tobacco-Related Disease Research Program (TRDRP), the most TRDRP grants the campus has received in any year.

6 Aug 2010

Salamander research findings bring scientists closer to future regenerative therapies

Tissue regeneration in salamanders and newts seems like it should be the stuff of science fiction. But it happens routinely. Why can't we mammals just re-grow a limb or churn out a few new heart muscle cells as needed? New research suggests there might be a very good reason: Restricting our cells' ability to pop in and out of the cell cycle at will - a prerequisite for the cell division necessary to make new tissue - reduces the chances that they'll run amok and form potentially deadly cancers.

6 Aug 2010

Cornerstone Pharmaceuticals includes Mary Crowley Research Centers in CPI-613 clinical trials

Cornerstone Pharmaceuticals, Inc. today announced the addition of Mary Crowley Cancer Research Centers to its roster of sites for its ongoing Phase I/II clinical trials of its first-in-class anti-cancer agent, CPI-613. Cornerstone is a leader in the discovery and development of cancer therapies that capitalize upon and disrupt the unique metabolic processes of cancer cells.

6 Aug 2010

CDS introduces new course on brain injury into its curriculum

The College of Direct Support, an internet-based college for Direct Support Professionals and managed in partnership by Elsevier/MC Strategies and the University of Minnesota's Research and Training Center, has introduced its fourth Disability Intensive Course into the CDS Curriculum - "Brain Injury."

6 Aug 2010

Researchers reprogram human embryonic stem cells to iPS cells for use in regenerative medicine

Human embryonic stem (ES) cells and adult cells reprogrammed to an embryonic stem cell-like state-so-called induced pluripotent stem or iPS cells-exhibit very few differences in their gene expression signatures and are nearly indistinguishable in their chromatin state, according to Whitehead Institute researchers.The pluripotency of ES cells fueled excitement over their use in regenerative medicine. While ethical hurdles associated with the clinical application of human ES cells appeared to have been overcome with the development of methods to create iPS cells, some recent research has suggested that ES and iPS cells have substantial differences in which sets of genes they express.

6 Aug 2010

Alnylam publishes research findings of Sort1 gene role in cardiovascular disease development

Alnylam Pharmaceuticals, Inc. a leading RNAi therapeutics company, announced today the publication of new research findings in the journal Nature describing the discovery and validation of the role of the gene Sort1 in the development of cardiovascular disease, including myocardial infarction (MI). This work was done with collaborators at University of Pennsylvania (UPenn) School of Medicine, Massachusetts General Hospital (MGH), and the Broad Institute. The collaborative effort combined genome-wide association studies (GWAS) and RNAi technology to identify and validate novel genes as targets for new therapies for heart disease.

6 Aug 2010

Study identifies options for restoring knee cartilage lubrication to prevent OA

An injury to the anterior cruciate ligament is fairly common, especially among young athletes. While it can often be corrected through surgery, the injury can lead to increased risk of developing degenerative joint diseases, including osteoarthritis. The problem is that fluid in the knee joint, which lubricates the cartilage, is impacted by the trauma of the injury and begins to deteriorate.

6 Aug 2010

New research on use of medicine, diet to prevent UV-induced skin cancer

In most cases, non-melanoma skin cancers are caused by overexposure to ultraviolet radiation - the invisible rays from the sun that can burn the skin. To reduce the risk of skin cancer, dermatologists encourage the public to Be Sun Smart, including limiting sun exposure and using broad-spectrum sunscreens.

6 Aug 2010

Scientists identify genetic variant that increases risk of schizophrenia

A group of scientists has identified a genetic variant that substantially increases the risk for developing schizophrenia in Ashkenazi Jewish and other populations. The study, published by Cell Press on August 5th in the American Journal of Human Genetics, associates a deletion on chromosome 3 with increased incidence of schizophrenia.

6 Aug 2010

Vesicular stomatitis virus kills tumour, stimulates immune response against cancer: Research

Cancer Research UK scientists have used the immune system coupled with a virus found in horses and cattle, to hunt and purge cancer cells through the lymphatic system, a study reveals in Nature Medicine.Studying mice, the researchers found that the vesicular stomatitis virus (VSV), carried by a type of white blood cell called T cells acted as a 'cancer hunter', tracking down tumour cells in the lymph nodes, liver and spleen, and killed them, leaving normal healthy cells unharmed. At the same time, VSV also helped to trigger an immune response against the tumour, significantly improving the anti-cancer effect.

6 Aug 2010

Scientists find new way to make beating heart cells from body's own cells

Scientists at the Gladstone Institute of Cardiovascular Disease have found a new way to make beating heart cells from the body's own cells that could help regenerate damaged hearts. Over 5 million Americans suffer from heart failure because the heart has virtually no ability to repair itself after a heart attack.

6 Aug 2010

Scientists find molecular cocktail to transform non-muscle cells into cardiac muscle

In heart disease, cardiac muscle gradually dies off and, with little or no way to regenerate those cells, that can ultimately lead the heart to fail. But scientists reporting in the August 6th issue of Cell, a Cell Press publication, might have found a way to fix those losses. They've devised a three-ingredient molecular cocktail that transforms fibroblasts - structural cells that the heart is chock full of - directly into beating heart cells.

6 Aug 2010

WaferGen launches SmartChip System for discovery, validation of biomarkers

WaferGen Biosystems, Inc., a leading developer of state-of-the-art genomic analysis systems, today announced it has launched the breakthrough WaferGen SmartChip Real-Time PCR System, the next-generation Real-Time PCR system for discovery and validation of biomarkers, or gene expression patterns, on a single platform. The SmartChip System is designed to provide accurate, highly sensitive and high-throughput gene expression profiling capabilities to researchers, clinicians and pharmaceutical companies.

6 Aug 2010

SeraCare optimizes ACCURUN 341 Nucleic Acid Positive controls

SeraCare Life Sciences, Inc. today announced that the Company has developed a new series of controls in its ACCURUN portfolio to monitor and validate molecular diagnostic test performance for detection of Chlamydia trachomatis and Neisseria gonorrhoeae (CT/NG). Through collaboration with instrument and reagent manufacturers, SeraCare has optimized the ACCURUN 341 Nucleic Acid Positive controls specifically for use with the three most popular assays currently on the market; the Gen-Probe APTIMA Combo 2 Assay, the Roche COBAS AMPLICOR CT/NG Test, and the Becton, Dickinson BD ProbeTec ET System.

6 Aug 2010

Sanofi-aventis receives FDA approval for new Taxotere Injection Concentrate formulation

Sanofi-aventis U.S. announced today that the U.S. Food and Drug Administration (FDA) has approved a new one-vial formulation of its chemotherapeutic agent Taxotere® (docetaxel) Injection Concentrate. The 1-vial Taxotere is anticipated to become available to cancer treatment clinics and hospitals nationwide in the fall in both 80 mg and 20 mg dosages.

5 Aug 2010

Ligand second-quarter net loss reduces to $0.3 million

Ligand Pharmaceuticals Incorporated today announced financial results for the three and six months ended June 30, 2010 and provided an update on key programs.

5 Aug 2010

Cell News and Research

Scientists identify role of PNPASE in regulating RNA import into mitochondria

JumpStart Ventures announces investment commitment of $250,000 in ChanRx

Elsevier Properties congratulates Stewart for achieving Lectureship

Norwegian cervical screening program begins reimbursing for liquid-based cytology

UC Riverside scientists secure grants for tobacco control research

Salamander research findings bring scientists closer to future regenerative therapies

Cornerstone Pharmaceuticals includes Mary Crowley Research Centers in CPI-613 clinical trials

CDS introduces new course on brain injury into its curriculum

Researchers reprogram human embryonic stem cells to iPS cells for use in regenerative medicine

Alnylam publishes research findings of Sort1 gene role in cardiovascular disease development

Study identifies options for restoring knee cartilage lubrication to prevent OA

New research on use of medicine, diet to prevent UV-induced skin cancer

Scientists identify genetic variant that increases risk of schizophrenia

Vesicular stomatitis virus kills tumour, stimulates immune response against cancer: Research

Scientists find new way to make beating heart cells from body's own cells

Scientists find molecular cocktail to transform non-muscle cells into cardiac muscle

WaferGen launches SmartChip System for discovery, validation of biomarkers

SeraCare optimizes ACCURUN 341 Nucleic Acid Positive controls

Sanofi-aventis receives FDA approval for new Taxotere Injection Concentrate formulation

Ligand second-quarter net loss reduces to $0.3 million

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