Immune Response News and Research

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Universal pan-filovirus T-cell vaccine could offer protection against Ebola and Marburg

Vaccines that induce protective T-cell responses could protect against members across the filovirus family, according to a study published February 28 in the open-access journal PLOS Pathogens by Tomáš Hanke of the University of Oxford, Bette Korber of the Los Alamos National Laboratory, and colleagues.

4 Mar 2019

Increased muscle mass could save your life

As far back as Ancient Greece, a sculptured physique has been heralded as the pinnacle of physical perfection. But now, researchers from Japan have found that increased muscle mass doesn't just make you look good, it could literally save your life.

4 Mar 2019

Aging and high-fat diet disrupt gut microbiome to cause inflammation in heart failure

Growing older and a high-fat diet enriched with omega 6 fatty acids are major contributors to health risks ranging from diabetes to heart failure. How these two factors regulate the immune response is not well-understood.

1 Mar 2019

Translucent wonder material used on stadium roofs helps measure protein particles

Understanding how proteins clump together is essential in modern pharmaceuticals. When these tiny particles aggregate, they can alter the effectiveness of both vaccines and drugs, especially many of the new, popular formulations derived from monoclonal antibodies.

1 Mar 2019

Lipid-filled particle plays role in immune function and metabolism

Researchers have discovered that fat tissue releases a lipid-filled particle that has a role in immune function and metabolism. The study, in mice, was published online in the journal Science.

1 Mar 2019

CHOP researchers use machine-learning models for early detection of sepsis in NICU infants

Automated programs can identify which sick infants in a neonatal intensive care unit (NICU) have sepsis hours before clinicians recognize the life-threatening condition.

1 Mar 2019

Personalized therapy for aggressive brain cancer shows potential

Advances in genetics and genomics have taught us that every single tumor is different, and yet most standard therapies treat them all in the same way, limiting the effectiveness of treatments offered to many cancer patients.

28 Feb 2019

Custom-designed proteins may help generate antibodies to inhibit HIV infection

A new way to create proteins that can sneak through HIV's protective coating may be a step toward understanding the key components needed for developing a vaccine for the virus, according to researchers.

27 Feb 2019

Study uncovers mechanism that controls immune reactions against gut microbiota

Researchers from the Cluster of Excellence "Precision Medicine in Chronic Inflammation" in Kiel and Charité - Universitätsmedizin Berlin have uncovered a critical mechanism that controls immune reactions against microorganisms in the intestine.

27 Feb 2019

Scientists use CRISPR to reveal the secret life of antimicrobial peptides

When it comes to the immune system, we usually think about lymphocytes like B and T cells or macrophages going on constant seek-and-destroy missions against invading pathogens like bacteria and viruses.

26 Feb 2019

Newly developed probe looks, acts, and feels so much like real neuron

Like a well-guarded fortress, the human brain attacks intruders on sight. Foreign objects, including neural probes used to study and treat the brain, do not last long.

26 Feb 2019

Risk of tick bite potentially leading to red meat allergy is higher than expected

Until now it has been believed that in order for a tick to trigger an allergic immune response to alpha-gal in humans, the tick would need to have recently fed on the alpha-gal-rich blood of a mammal.

25 Feb 2019

Researchers engineer 'antibody-like' T cell receptors to combat deadly virus

Researchers have engineered "antibody-like" T cell receptors that can specifically stick to cells infected with cytomegalovirus, or CMV, a virus that causes lifelong infection in more than half of all adults by age 40.

23 Feb 2019

Researchers unravel how specific intestinal microbiota amplify inflammatory reactions in the lungs

The composition of the microbiome - the countless bacteria, fungi and viruses that colonize our body surface, skin, intestines or lungs - makes a decisive contribution to human health or disease.

23 Feb 2019

New optimization method rapidly analyzes nanomedicines for cancer treatment

With their ability to treat a wide a variety of diseases, spherical nucleic acids (SNAs) are poised to revolutionize medicine. But before these digitally designed nanostructures can reach their full potential, researchers need to optimize their various components.

20 Feb 2019

T-cells play key role in how the body fights follicular lymphoma

Healthy white blood cells, called "T-cells," play a crucial role in how the body fights follicular lymphoma. That's according to the results of a study led by Mayo Clinic hematologists Zhi Zhang Yang, M.D., and Stephen Ansell, M.D., Ph.D., that was published in Cell Reports.

20 Feb 2019

New forms of older anti-cancer agent appear to enhance immune response to fight melanoma

Researchers at the Bloomberg~Kimmel Institute for Cancer Immunotherapy at Johns Hopkins and the Johns Hopkins University School of Medicine report two new forms of an older anti-cancer agent they developed appear to enhance the immune system's ability to fight melanoma in mice.

20 Feb 2019

Study reveals how helper T cells support memory cells to function optimally

The immune system's killer T cells are crucial in fighting viral infections. A fraction of them, called 'memory cells', live on once infection is controlled in order to fight re-infection by the same virus. They are of great interest as the basis of T cell-based vaccination and immunotherapies.

20 Feb 2019

Single CRISPR treatment can safely and stably correct genetic disease

Researchers at Duke University have shown that a single systemic treatment using CRISPR genome editing technology can safely and stably correct a genetic disease -- Duchenne muscular dystrophy (DMD) -- for more than a year in mice, despite observed immune responses and alternative gene editing outcomes.

18 Feb 2019

CRISPR technology creates pluripotent stem cells that are 'invisible' to the immune system

UC San Francisco scientists have used the CRISPR-Cas9 gene-editing system to create the first pluripotent stem cells that are functionally "invisible" to the immune system, a feat of biological engineering that, in laboratory studies, prevented rejection of stem cell transplants.

18 Feb 2019

Immune Response News and Research

Universal pan-filovirus T-cell vaccine could offer protection against Ebola and Marburg

Increased muscle mass could save your life

Aging and high-fat diet disrupt gut microbiome to cause inflammation in heart failure

Translucent wonder material used on stadium roofs helps measure protein particles

Lipid-filled particle plays role in immune function and metabolism

CHOP researchers use machine-learning models for early detection of sepsis in NICU infants

Personalized therapy for aggressive brain cancer shows potential

Custom-designed proteins may help generate antibodies to inhibit HIV infection

Study uncovers mechanism that controls immune reactions against gut microbiota

Scientists use CRISPR to reveal the secret life of antimicrobial peptides

Newly developed probe looks, acts, and feels so much like real neuron

Risk of tick bite potentially leading to red meat allergy is higher than expected

Researchers engineer 'antibody-like' T cell receptors to combat deadly virus

Researchers unravel how specific intestinal microbiota amplify inflammatory reactions in the lungs

New optimization method rapidly analyzes nanomedicines for cancer treatment

T-cells play key role in how the body fights follicular lymphoma

New forms of older anti-cancer agent appear to enhance immune response to fight melanoma

Study reveals how helper T cells support memory cells to function optimally

Single CRISPR treatment can safely and stably correct genetic disease

CRISPR technology creates pluripotent stem cells that are 'invisible' to the immune system

Industry Focus eBook - Cell & Gene Therapy (1st Edition) eBook

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

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