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Heptares starts HTL9936 Phase 1 study for improving cognitive function in Alzheimer's patients

Heptares Therapeutics, the leading GPCR structure-guided drug discovery and development company, announces that it has initiated a Phase 1 clinical study of HTL9936, the first fully selective muscarinic M1 receptor agonist to enter clinical development. HTL9936 is an orally available, small molecule drug candidate discovered using the Heptares GPCR structure-based drug design platform.

9 Dec 2013

NYSCF, PersonalGenomes.org partner to identify genetic contributions to disease development

Today, the New York Stem Cell Foundation Research Institute and PersonalGenomes.org announced a partnership to identify genetic and environmental contributions to trait and disease development. Cell lines generated by NYSCF will complement genomic data and medical histories contributed by participants in the Harvard Personal Genome Project, creating a unique and powerful resource to help researchers identify causes of disease.

9 Dec 2013

UC Santa Barbara extends research contract with Army Research Laboratory

UC Santa Barbara's Institute for Collaborative Biotechnologies has received an extension of its contract with the U.S. Army Research Laboratory-Army Research Office, providing an additional $48 million over three years to support research that is inspired by biological systems. The continuation in ICB funding speaks to the success of a decade of fundamental research in the areas of biotechnology, chemistry, engineering, physics, materials science, computer science, neuroscience and medicine.

9 Dec 2013

Penn researchers identify protein that could clear Alzheimer's plaques

The body is structured to ensure that any invading organisms have a tough time reaching the brain, an organ obviously critical to survival. Known as the blood-brain barrier, cells that line the brain and spinal cord are tightly packed, making it difficult for anything besides very small molecules to cross from the bloodstream into the central nervous system. While beneficial, this blockade also stands in the way of delivering drugs intended to treat neurological disorders, such as Alzheimer's.

9 Dec 2013

New study presents promising results for treatment of multiple myeloma

A new study conducted by scientists from the Dana-Farber Cancer Institute at Harvard Medical School, USA, and Karolinska Institutet, Sweden, presents very promising results for the treatment of the cancer form multiple myeloma. The drug candidate used in the research has been developed by scientists from Karolinska Institutet and a Swedish company following its initial identification at the same university. The findings are so promising that the scientists are teaming up with Harvard to bring the drug to clinical trials on patients.

9 Dec 2013

Genetically engineered cell therapies demonstrate early efficacy, safety in patients with blood disorders

A series of advancements in genetically engineered cell therapies demonstrate early efficacy and safety in patients with blood disorders for whom standard treatments have been unsuccessful, according to data showcased today during the 55th American Society of Hematology (ASH) Annual Meeting and Exposition in New Orleans.

9 Dec 2013

New web-based tool empowers people with epilepsy to seek specialized care

Receiving specialized care in a timely manner plays a significant role in the progression and impact of epilepsy on someone's life. Multiple organizations across the global epilepsy community have collaborated on "My Seizure, Know More" a web-based tool that empowers people with epilepsy and their families to seek specialized care.

9 Dec 2013

Researchers uncover biological factor that may contribute to disparities in prostate cancer incidence

Researchers have uncovered a potential biological factor that may contribute to disparities in prostate cancer incidence and mortality between African-American and non-Hispanic white men in the United States, according to results presented here at the Sixth AACR Conference on the Science of Cancer Health Disparities in Racial/Ethnic Minorities and the Medically Underserved, held Dec. 6-9.

9 Dec 2013

Every hour, every day a child is taken to a hospital as injuries surge 22 percent

High chairs and booster seats are commonly used to help make feeding young children easier. Although most parents assume these products are safe, millions have been recalled in recent years, and injuries associated with their use continue to occur.

9 Dec 2013

Viewpoints: Health law is here to stay; problems for Obamacare go beyond website; future 'doc shock'

For almost two months, the debacle of healthcare.gov allowed conservatives to live the life they always wanted. Health reform was a dismal failure; Obama would go down in history as a laughingstock; government can't do anything; viva Ayn Rand! ... while things are far from completely fixed, the crisis is clearly over. Obamacare will have millions of beneficiaries by the time open enrollment ends; it will add many more in the 2015 cycle. Health reform is pretty much irreversible at this point (Paul Krugman, 12/5).

9 Dec 2013

MRI-guided SLA surgery proves safe and shows adequate efficacy for seizure control

MRI-Guided Stereotactic Laser Ablation of the hippocampus to control seizures in people with temporal lobe epilepsy may result in seizure control that approaches that from anterior temporal lobectory or selective amygdalohippocampectomy and better cognitive outcomes than any of the standard open resections, according to a study presented at the American Epilepsy Society's 67th Annual Meeting in Washington DC.

9 Dec 2013

Taking probiotics during pregnancy has no effect on asthma rate amoung infants

Taking probiotics has health benefits but preventing childhood asthma isn't one of them, shows newly published research led by medical scientists at the University of Alberta.

9 Dec 2013

Angioplasty may not provide additional benefits compared to drug therapy for patients with stable CAD

For patients with stable coronary artery disease (CAD) who are not experiencing a heart attack and an abnormal stress test, treatment of their narrowed arteries by the common procedure of angioplasty may not provide additional benefits compared to drug therapy alone.

9 Dec 2013

Research roundup: 'Substantial' Medicare savings from avoiding ERs; new ways for primary care; trends in kids' fast food consumption

Some Medicare beneficiaries who place 911 calls to request an ambulance might safely be cared for in settings other than the emergency department at lower cost. Using 2005–09 Medicare claims data and a validated algorithm, we estimated that 12.9–16.2 percent of Medicare-covered 911 emergency medical services transports involved conditions that were probably nonemergent or primary care treatable.

9 Dec 2013

Study helps explain why survival gap persists for African-Americans with head and neck cancer

A team of scientists at Johns Hopkins and in Texas has identified a handful of genetic mutations in black Americans, in addition to some chemical alterations affecting gene activity, which may help explain why the death rate among African-Americans from the most common form of head and neck cancer continues to hover some 18 percent higher above the death rate of whites with the same cancer.

9 Dec 2013

UCSF awarded $9.45M federal grant to transform, revolutionize treatment of prostate cancer

UC San Francisco has been awarded a major federal grant to "transform and revolutionize" the treatment of prostate cancer, the second most common form of cancer among American men.

9 Dec 2013

Scientists receive 2013 Horwitz Prize for discoveries on how brain calculates location, navigation

Edvard and May-Britt Moser of the Norwegian University of Science and Technology (NTNU), and John O'Keefe, from University College London have been awarded the 2013 Louisa Gross Horwitz Prize for discoveries that have illuminated how the brain calculates location and navigation.

9 Dec 2013

NIH scientists film early concussion damage and describe brain's response to injury

There is more than meets the eye following even a mild traumatic brain injury. While the brain may appear to be intact, new findings reported in Nature suggest that the brain's protective coverings may feel the brunt of the impact.

9 Dec 2013

Decreased bacterial diversity in gut linked with CRC risk

Decreased diversity in the microbial community found in the human gut is associated with colorectal cancer, according to a new study published December 6 in the Journal of the National Cancer Institute.

9 Dec 2013

Study: Ethnic groups with high prevalence of diabetes have high hepatocellular carcinoma rates

Diabetes was associated with an increased risk for developing a type of liver cancer called hepatocellular carcinoma, and this association was highest for Latinos, followed by Hawaiians, African-Americans, and Japanese-Americans, according to results presented here at the Sixth AACR Conference on the Science of Cancer Health Disparities in Racial/Ethnic Minorities and the Medically Underserved, held Dec. 6-9.

9 Dec 2013

Medicine News and Research

Heptares starts HTL9936 Phase 1 study for improving cognitive function in Alzheimer's patients

NYSCF, PersonalGenomes.org partner to identify genetic contributions to disease development

UC Santa Barbara extends research contract with Army Research Laboratory

Penn researchers identify protein that could clear Alzheimer's plaques

New study presents promising results for treatment of multiple myeloma

Genetically engineered cell therapies demonstrate early efficacy, safety in patients with blood disorders

New web-based tool empowers people with epilepsy to seek specialized care

Researchers uncover biological factor that may contribute to disparities in prostate cancer incidence

Every hour, every day a child is taken to a hospital as injuries surge 22 percent

Viewpoints: Health law is here to stay; problems for Obamacare go beyond website; future 'doc shock'

MRI-guided SLA surgery proves safe and shows adequate efficacy for seizure control

Taking probiotics during pregnancy has no effect on asthma rate amoung infants

Angioplasty may not provide additional benefits compared to drug therapy for patients with stable CAD

Research roundup: 'Substantial' Medicare savings from avoiding ERs; new ways for primary care; trends in kids' fast food consumption

Study helps explain why survival gap persists for African-Americans with head and neck cancer

UCSF awarded $9.45M federal grant to transform, revolutionize treatment of prostate cancer

Scientists receive 2013 Horwitz Prize for discoveries on how brain calculates location, navigation

NIH scientists film early concussion damage and describe brain's response to injury

Decreased bacterial diversity in gut linked with CRC risk

Study: Ethnic groups with high prevalence of diabetes have high hepatocellular carcinoma rates

Everything there is to know about biosimilars eBook

Improving healthcare sustainability through carbon data

Managing vibration in IVF laboratories

A New Approach to Preventing Bladder Cancer Recurrence

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