Immune Response News and Research

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Researchers discover immune cells that create and sustain chronic inflammatory bowel disease

In preclinical experiments, Laurie Harrington, Ph.D., and colleagues at the University of Alabama at Birmingham have discovered a subset of immune cells that create and sustain chronic inflammatory bowel disease.

27 Jun 2018

Phase 1 clinical trial of poliovirus therapy shows long-term survival benefit for recurrent glioblastoma

A genetically modified poliovirus therapy developed at Duke Cancer Institute shows significantly improved long-term survival for patients with recurrent glioblastoma, with a three-year survival rate of 21 percent in a phase 1 clinical trial.

26 Jun 2018

Researchers discover immune profile for effective cancer immunotherapy

In a new study published online June 25, 2018 in Nature Medicine, UC San Francisco researchers have identified a key biological pathway in human cancer patients that appears to prime the immune system for a successful response to immunotherapy drugs known as checkpoint inhibitors.

25 Jun 2018

Study reveals new target to halt tumor growth

Researchers at the University of Wisconsin-Madison have discovered that a protein called Munc13-4 helps cancer cells secrete large numbers of exosomes - tiny, membrane-bound packages containing proteins and RNAs that stimulate tumor progression.

21 Jun 2018

New study sheds light on role of vitamin D in healthy pregnancy

For a pregnancy to proceed to term, early modulation of the immunologic response is required to induce tolerance to the fetus.

20 Jun 2018

Monash study reveals why older people have reduced immune responses to cancer therapy

It's called the Silver Tsunami - the increased incidence of cancer with aging, combined with the rapidly aging population means that the Australian health system needs to prepare for an onslaught of cancer diagnoses.

20 Jun 2018

Gene signature could improve early diagnosis of TB

Researchers have identified a gene signature that could determine whether a person is going to develop TB, months before they show any symptoms.

19 Jun 2018

Scientists create universal assembly method to enhance cancer therapy and diagnostics

Biophysicists have developed a method for modifying the surface of micro- and nanoparticles — tiny structures measuring between a thousandth and a millionth of a millimeter — by covering them with biological molecules. Engineered in this way, the particles can serve as both therapeutic and diagnostic agents, delivering drugs to cancer cells.

19 Jun 2018

Studies provide insight into molecular changes prior to onset of arthritis

The results of two studies presented today at the Annual European Congress of Rheumatology (EULAR 2018) provide insight into molecular changes prior to the onset of arthritis which could inform future novel diagnostics and early therapeutic interventions.

18 Jun 2018

Study: Lenabasum has acceptable safety and tolerability in diffuse cutaneous systemic sclerosis

The results of an open label extension of a phase II study presented today at the Annual European Congress of Rheumatology, 2018, demonstrate that lenabasum continues to have acceptable safety and tolerability in diffuse cutaneous systemic sclerosis with no severe or serious adverse events.

18 Jun 2018

NIAID launches clinical trial of investigational RSV vaccine

The National Institute of Allergy and Infectious Diseases, part of the National Institutes of Health, has launched a clinical trial of an investigational vaccine designed to protect against respiratory syncytial virus.

14 Jun 2018

Scientists discover vaccine that may rapidly fight cholera-causing bacteria

A tricked-out cholera vaccine starts protecting against the deadly disease within a day, experiments in rabbits suggest.

14 Jun 2018

New study shows how vitamin A effectively supports lung immunity against TB

Scientists at Trinity College Dublin and St James's Hospital, Dublin, have discovered how vitamin A drives the lung immune system to deal with tuberculosis

14 Jun 2018

Older melanoma patients fare better on immune checkpoint blockade therapy

Patient age correlates with response to immunotherapy in melanoma and depleting regulatory T cells in young patients may have a therapeutic potential to enhance response in younger patients, according to research from The Wistar Institute. Study results were published online in Clinical Cancer Research.

13 Jun 2018

Researchers develop spider silk microcapsules that can deliver vaccine directly to immune cells

To fight cancer, researchers increasingly use vaccines that stimulate the immune system to identify and destroy tumor cells.

12 Jun 2018

Immune response in RA patients linked to inflammation and joint damage

To diagnose rheumatoid arthritis, antibodies to the amino acid citrulline are commonly measured. A new study from Uppsala University shows that a broad mix of different antibodies in the joints is the dominant factor that can be associated with severe inflammation and joint damage.

12 Jun 2018

Customising T-cells for cancer immunotherapy

T-cell immunotherapy is revolutionizing cancer treatments. CD8+ T cells are modified to recognize tumor-specific antigens and induce an immune response.

12 Jun 2018

Hydrogel releases nerve-protecting agent to restore breathing in animal models

One of the most severe outcomes of spinal cord injury from car accidents, sports impacts, or other neck trauma, is losing the ability to control breathing, with patients often requiring artificial ventilation for the rest of their lives.

12 Jun 2018

Mice study shows beneficial effect of MANF treatment on reversal of stroke-induced behavioral deficits

Stroke is the most common cause of adult disability. This is due not only to the high incidence of stroke, but also because spontaneous recovery is often incomplete and no drugs are available that hasten recovery.

11 Jun 2018

Translate Bio collaborates with Sanofi to develop mRNA vaccines for infectious diseases

Translate Bio, a clinical-stage messenger RNA therapeutics company developing a new class of potentially transformative medicines to treat diseases caused by protein or gene dysfunction, announced today a multi-year research and development collaboration and exclusive licensing agreement with Sanofi Pasteur, the vaccines global business unit of Sanofi, to develop mRNA vaccines for up to five undisclosed infectious disease pathogens.

11 Jun 2018

Immune Response News and Research

Researchers discover immune cells that create and sustain chronic inflammatory bowel disease

Phase 1 clinical trial of poliovirus therapy shows long-term survival benefit for recurrent glioblastoma

Researchers discover immune profile for effective cancer immunotherapy

Study reveals new target to halt tumor growth

New study sheds light on role of vitamin D in healthy pregnancy

Monash study reveals why older people have reduced immune responses to cancer therapy

Gene signature could improve early diagnosis of TB

Scientists create universal assembly method to enhance cancer therapy and diagnostics

Studies provide insight into molecular changes prior to onset of arthritis

Study: Lenabasum has acceptable safety and tolerability in diffuse cutaneous systemic sclerosis

NIAID launches clinical trial of investigational RSV vaccine

Scientists discover vaccine that may rapidly fight cholera-causing bacteria

New study shows how vitamin A effectively supports lung immunity against TB

Older melanoma patients fare better on immune checkpoint blockade therapy

Researchers develop spider silk microcapsules that can deliver vaccine directly to immune cells

Immune response in RA patients linked to inflammation and joint damage

Customising T-cells for cancer immunotherapy

Hydrogel releases nerve-protecting agent to restore breathing in animal models

Mice study shows beneficial effect of MANF treatment on reversal of stroke-induced behavioral deficits

Translate Bio collaborates with Sanofi to develop mRNA vaccines for infectious diseases

Understanding the DNA Damage Response in Innate Immunity eBook

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

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